![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: LRRIQ1 |
Gene summary for LRRIQ1 |
![]() |
Gene information | Species | Human | Gene symbol | LRRIQ1 | Gene ID | 84125 |
Gene name | leucine rich repeats and IQ motif containing 1 | |
Gene Alias | LRRIQ1 | |
Cytomap | 12q21.31 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | A0A140VJN5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84125 | LRRIQ1 | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 9.93e-08 | 1.04e+00 | -0.0238 |
84125 | LRRIQ1 | RNA-P6T1-P6T1-2 | Human | Lung | MIAC | 3.39e-12 | 1.21e+00 | -0.0186 |
84125 | LRRIQ1 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 2.21e-10 | 1.22e+00 | -0.0296 |
84125 | LRRIQ1 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 2.95e-10 | 1.04e+00 | -0.0263 |
84125 | LRRIQ1 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 1.74e-03 | 3.98e-01 | -0.0822 |
84125 | LRRIQ1 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 4.67e-04 | 3.88e-01 | -0.0809 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRIQ1 | SNV | Missense_Mutation | novel | c.1942N>T | p.Asp648Tyr | p.D648Y | Q96JM4 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LRRIQ1 | SNV | Missense_Mutation | rs747439668 | c.4115N>A | p.Ser1372Tyr | p.S1372Y | Q96JM4 | protein_coding | tolerated(0.5) | benign(0.009) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LRRIQ1 | SNV | Missense_Mutation | novel | c.4581N>T | p.Lys1527Asn | p.K1527N | Q96JM4 | protein_coding | deleterious(0.05) | probably_damaging(0.976) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LRRIQ1 | insertion | Frame_Shift_Ins | novel | c.2093_2094insAGTTGTGT | p.Lys699ValfsTer30 | p.K699Vfs*30 | Q96JM4 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
LRRIQ1 | insertion | Frame_Shift_Ins | novel | c.1740_1741insA | p.Ile583AspfsTer18 | p.I583Dfs*18 | Q96JM4 | protein_coding | TCGA-AZ-6608-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
LRRIQ1 | insertion | Frame_Shift_Ins | rs779699744 | c.1463_1464insA | p.Arg491ThrfsTer14 | p.R491Tfs*14 | Q96JM4 | protein_coding | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | ||
LRRIQ1 | insertion | Frame_Shift_Ins | rs779699744 | c.1463_1464insA | p.Arg491ThrfsTer14 | p.R491Tfs*14 | Q96JM4 | protein_coding | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | ||
LRRIQ1 | insertion | Frame_Shift_Ins | novel | c.649_650insA | p.Lys219GlufsTer16 | p.K219Efs*16 | Q96JM4 | protein_coding | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LRRIQ1 | insertion | Frame_Shift_Ins | rs745692987 | c.4624dupA | p.Ile1542AsnfsTer8 | p.I1542Nfs*8 | Q96JM4 | protein_coding | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | ||
LRRIQ1 | SNV | Missense_Mutation | novel | c.2336N>T | p.Pro779Leu | p.P779L | Q96JM4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |