![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: LRRC8A |
Gene summary for LRRC8A |
![]() |
Gene information | Species | Human | Gene symbol | LRRC8A | Gene ID | 56262 |
Gene name | leucine rich repeat containing 8 VRAC subunit A | |
Gene Alias | AGM5 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R892 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56262 | LRRC8A | LZE2D | Human | Esophagus | HGIN | 3.20e-02 | -3.10e-01 | 0.0642 |
56262 | LRRC8A | LZE4T | Human | Esophagus | ESCC | 2.67e-08 | -2.65e-01 | 0.0811 |
56262 | LRRC8A | LZE5T | Human | Esophagus | ESCC | 1.76e-05 | -8.30e-02 | 0.0514 |
56262 | LRRC8A | LZE7T | Human | Esophagus | ESCC | 2.47e-04 | 3.24e-02 | 0.0667 |
56262 | LRRC8A | LZE22D1 | Human | Esophagus | HGIN | 1.38e-05 | -3.73e-01 | 0.0595 |
56262 | LRRC8A | LZE24T | Human | Esophagus | ESCC | 2.18e-05 | 2.77e-01 | 0.0596 |
56262 | LRRC8A | P2T-E | Human | Esophagus | ESCC | 4.38e-13 | 1.91e-02 | 0.1177 |
56262 | LRRC8A | P4T-E | Human | Esophagus | ESCC | 1.44e-07 | 6.09e-02 | 0.1323 |
56262 | LRRC8A | P5T-E | Human | Esophagus | ESCC | 4.42e-14 | -1.81e-01 | 0.1327 |
56262 | LRRC8A | P8T-E | Human | Esophagus | ESCC | 1.88e-15 | 2.98e-01 | 0.0889 |
56262 | LRRC8A | P9T-E | Human | Esophagus | ESCC | 7.57e-08 | 2.05e-01 | 0.1131 |
56262 | LRRC8A | P10T-E | Human | Esophagus | ESCC | 1.79e-11 | 3.23e-01 | 0.116 |
56262 | LRRC8A | P12T-E | Human | Esophagus | ESCC | 1.39e-03 | 2.68e-01 | 0.1122 |
56262 | LRRC8A | P15T-E | Human | Esophagus | ESCC | 4.03e-15 | 5.87e-01 | 0.1149 |
56262 | LRRC8A | P16T-E | Human | Esophagus | ESCC | 6.39e-19 | -4.31e-01 | 0.1153 |
56262 | LRRC8A | P17T-E | Human | Esophagus | ESCC | 2.98e-03 | -1.72e-01 | 0.1278 |
56262 | LRRC8A | P19T-E | Human | Esophagus | ESCC | 5.76e-09 | -2.28e-01 | 0.1662 |
56262 | LRRC8A | P20T-E | Human | Esophagus | ESCC | 1.58e-11 | -1.51e-01 | 0.1124 |
56262 | LRRC8A | P21T-E | Human | Esophagus | ESCC | 3.71e-05 | 2.62e-01 | 0.1617 |
56262 | LRRC8A | P22T-E | Human | Esophagus | ESCC | 8.20e-09 | -2.73e-02 | 0.1236 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001593116 | Esophagus | HGIN | nucleobase-containing compound transport | 57/2587 | 222/18723 | 1.76e-06 | 6.52e-05 | 57 |
GO:190495120 | Esophagus | HGIN | positive regulation of establishment of protein localization | 73/2587 | 319/18723 | 6.99e-06 | 2.14e-04 | 73 |
GO:005122220 | Esophagus | HGIN | positive regulation of protein transport | 67/2587 | 303/18723 | 5.13e-05 | 1.22e-03 | 67 |
GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:0051222111 | Esophagus | ESCC | positive regulation of protein transport | 204/8552 | 303/18723 | 1.56e-14 | 8.38e-13 | 204 |
GO:003253520 | Esophagus | ESCC | regulation of cellular component size | 227/8552 | 383/18723 | 4.77e-08 | 8.60e-07 | 227 |
GO:00069707 | Esophagus | ESCC | response to osmotic stress | 57/8552 | 84/18723 | 3.26e-05 | 2.70e-04 | 57 |
GO:00083619 | Esophagus | ESCC | regulation of cell size | 107/8552 | 181/18723 | 1.81e-04 | 1.16e-03 | 107 |
GO:19031317 | Esophagus | ESCC | mononuclear cell differentiation | 226/8552 | 426/18723 | 1.20e-03 | 5.88e-03 | 226 |
GO:00454454 | Esophagus | ESCC | myoblast differentiation | 52/8552 | 84/18723 | 1.98e-03 | 8.90e-03 | 52 |
GO:000930617 | Esophagus | ESCC | protein secretion | 190/8552 | 359/18723 | 3.22e-03 | 1.34e-02 | 190 |
GO:00512592 | Esophagus | ESCC | protein complex oligomerization | 130/8552 | 238/18723 | 3.29e-03 | 1.36e-02 | 130 |
GO:003559217 | Esophagus | ESCC | establishment of protein localization to extracellular region | 190/8552 | 360/18723 | 3.77e-03 | 1.53e-02 | 190 |
GO:007169210 | Esophagus | ESCC | protein localization to extracellular region | 193/8552 | 368/18723 | 5.01e-03 | 1.92e-02 | 193 |
GO:005070810 | Esophagus | ESCC | regulation of protein secretion | 142/8552 | 268/18723 | 9.31e-03 | 3.24e-02 | 142 |
GO:005071416 | Esophagus | ESCC | positive regulation of protein secretion | 76/8552 | 137/18723 | 1.32e-02 | 4.31e-02 | 76 |
GO:00300984 | Esophagus | ESCC | lymphocyte differentiation | 192/8552 | 374/18723 | 1.52e-02 | 4.93e-02 | 192 |
GO:00512227 | Liver | NAFLD | positive regulation of protein transport | 55/1882 | 303/18723 | 1.07e-05 | 3.35e-04 | 55 |
GO:19049517 | Liver | NAFLD | positive regulation of establishment of protein localization | 55/1882 | 319/18723 | 4.79e-05 | 1.14e-03 | 55 |
Page: 1 2 3 4 5 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRC8A | SNV | Missense_Mutation | novel | c.38N>T | p.Thr13Met | p.T13M | Q8IWT6 | protein_coding | tolerated(0.13) | possibly_damaging(0.885) | TCGA-CV-5430-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
LRRC8A | SNV | Missense_Mutation | novel | c.1141N>G | p.Gln381Glu | p.Q381E | Q8IWT6 | protein_coding | deleterious(0.04) | probably_damaging(0.977) | TCGA-CV-7407-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LRRC8A | SNV | Missense_Mutation | novel | c.1048N>C | p.Lys350Gln | p.K350Q | Q8IWT6 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-DQ-5631-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
LRRC8A | SNV | Missense_Mutation | novel | c.371N>G | p.Tyr124Cys | p.Y124C | Q8IWT6 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LRRC8A | SNV | Missense_Mutation | rs752328296 | c.1241N>T | p.Asp414Val | p.D414V | Q8IWT6 | protein_coding | deleterious(0) | benign(0.085) | TCGA-HD-A6I0-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LRRC8A | SNV | Missense_Mutation | c.2149N>A | p.Ala717Thr | p.A717T | Q8IWT6 | protein_coding | tolerated(0.41) | possibly_damaging(0.472) | TCGA-KK-A59V-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
LRRC8A | SNV | Missense_Mutation | rs778176423 | c.2053C>T | p.Arg685Cys | p.R685C | Q8IWT6 | protein_coding | tolerated(0.09) | probably_damaging(0.964) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
LRRC8A | SNV | Missense_Mutation | rs760232174 | c.1772N>T | p.Ala591Val | p.A591V | Q8IWT6 | protein_coding | tolerated(0.97) | benign(0) | TCGA-XK-AAJ3-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Unknown | Unknown | SD |
LRRC8A | SNV | Missense_Mutation | rs749079625 | c.1454C>T | p.Ala485Val | p.A485V | Q8IWT6 | protein_coding | tolerated(0.52) | benign(0.137) | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LRRC8A | SNV | Missense_Mutation | rs769346865 | c.686N>T | p.Thr229Met | p.T229M | Q8IWT6 | protein_coding | tolerated(0.51) | possibly_damaging(0.487) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |