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Gene: LRRC40 |
Gene summary for LRRC40 |
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Gene information | Species | Human | Gene symbol | LRRC40 | Gene ID | 55631 |
Gene name | leucine rich repeat containing 40 | |
Gene Alias | dJ677H15.1 | |
Cytomap | 1p31.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A0A140VJN3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55631 | LRRC40 | LZE4T | Human | Esophagus | ESCC | 1.62e-03 | 7.88e-02 | 0.0811 |
55631 | LRRC40 | LZE24T | Human | Esophagus | ESCC | 1.05e-05 | 1.22e-01 | 0.0596 |
55631 | LRRC40 | P2T-E | Human | Esophagus | ESCC | 1.72e-17 | 2.60e-01 | 0.1177 |
55631 | LRRC40 | P4T-E | Human | Esophagus | ESCC | 7.29e-17 | 1.85e-01 | 0.1323 |
55631 | LRRC40 | P5T-E | Human | Esophagus | ESCC | 3.52e-07 | 1.03e-01 | 0.1327 |
55631 | LRRC40 | P8T-E | Human | Esophagus | ESCC | 8.62e-11 | 1.50e-01 | 0.0889 |
55631 | LRRC40 | P9T-E | Human | Esophagus | ESCC | 4.37e-08 | 5.20e-02 | 0.1131 |
55631 | LRRC40 | P10T-E | Human | Esophagus | ESCC | 2.43e-05 | 1.56e-01 | 0.116 |
55631 | LRRC40 | P11T-E | Human | Esophagus | ESCC | 1.70e-02 | 9.94e-02 | 0.1426 |
55631 | LRRC40 | P12T-E | Human | Esophagus | ESCC | 1.72e-12 | 1.68e-01 | 0.1122 |
55631 | LRRC40 | P15T-E | Human | Esophagus | ESCC | 3.29e-14 | 1.79e-01 | 0.1149 |
55631 | LRRC40 | P16T-E | Human | Esophagus | ESCC | 5.56e-16 | 1.02e-01 | 0.1153 |
55631 | LRRC40 | P19T-E | Human | Esophagus | ESCC | 4.51e-06 | 3.13e-01 | 0.1662 |
55631 | LRRC40 | P20T-E | Human | Esophagus | ESCC | 1.53e-15 | 1.39e-01 | 0.1124 |
55631 | LRRC40 | P21T-E | Human | Esophagus | ESCC | 1.90e-14 | 2.59e-01 | 0.1617 |
55631 | LRRC40 | P22T-E | Human | Esophagus | ESCC | 1.83e-05 | 5.23e-02 | 0.1236 |
55631 | LRRC40 | P23T-E | Human | Esophagus | ESCC | 7.15e-10 | 1.72e-01 | 0.108 |
55631 | LRRC40 | P24T-E | Human | Esophagus | ESCC | 4.08e-03 | 9.64e-02 | 0.1287 |
55631 | LRRC40 | P26T-E | Human | Esophagus | ESCC | 3.15e-11 | 1.46e-01 | 0.1276 |
55631 | LRRC40 | P27T-E | Human | Esophagus | ESCC | 6.22e-14 | 1.72e-01 | 0.1055 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRC40 | SNV | Missense_Mutation | novel | c.1481N>A | p.Leu494Gln | p.L494Q | Q9H9A6 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CV-7250-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
LRRC40 | SNV | Missense_Mutation | rs746389314 | c.814N>A | p.Val272Ile | p.V272I | Q9H9A6 | protein_coding | tolerated(0.27) | benign(0.007) | TCGA-CV-A6K1-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
LRRC40 | SNV | Missense_Mutation | novel | c.1528N>G | p.Leu510Val | p.L510V | Q9H9A6 | protein_coding | tolerated(0.23) | benign(0.086) | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD |
LRRC40 | insertion | Nonsense_Mutation | novel | c.1529_1530insGTAGTT | p.Leu510_Pro511insTer | p.L510_P511ins* | Q9H9A6 | protein_coding | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD | ||
LRRC40 | SNV | Missense_Mutation | c.212N>T | p.Ser71Leu | p.S71L | Q9H9A6 | protein_coding | tolerated(0.08) | benign(0.311) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
LRRC40 | SNV | Missense_Mutation | c.1351G>T | p.Val451Phe | p.V451F | Q9H9A6 | protein_coding | deleterious(0.01) | possibly_damaging(0.757) | TCGA-CG-4466-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LRRC40 | insertion | Frame_Shift_Ins | novel | c.1623_1624insAAAAA | p.Glu542LysfsTer5 | p.E542Kfs*5 | Q9H9A6 | protein_coding | TCGA-BR-8486-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LRRC40 | insertion | In_Frame_Ins | novel | c.1622_1623insTTATCT | p.Met541delinsIleTyrLeu | p.M541delinsIYL | Q9H9A6 | protein_coding | TCGA-BR-8486-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LRRC40 | insertion | Frame_Shift_Ins | novel | c.543_544insCAAATTTATGTATTATG | p.Ser182GlnfsTer34 | p.S182Qfs*34 | Q9H9A6 | protein_coding | TCGA-BJ-A45F-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
LRRC40 | insertion | In_Frame_Ins | novel | c.1605_1606insAACTTCTTG | p.Pro535_Gln536insAsnPheLeu | p.P535_Q536insNFL | Q9H9A6 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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