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Gene: LONRF3 |
Gene summary for LONRF3 |
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Gene information | Species | Human | Gene symbol | LONRF3 | Gene ID | 79836 |
Gene name | LON peptidase N-terminal domain and ring finger 3 | |
Gene Alias | RNF127 | |
Cytomap | Xq24 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A8K2D3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79836 | LONRF3 | male-WTA | Human | Thyroid | PTC | 1.87e-02 | -1.33e-01 | 0.1037 |
79836 | LONRF3 | PTC04 | Human | Thyroid | PTC | 6.40e-13 | 3.01e-01 | 0.1927 |
79836 | LONRF3 | PTC07 | Human | Thyroid | PTC | 5.48e-10 | 1.74e-01 | 0.2044 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LONRF3 | SNV | Missense_Mutation | c.1078N>T | p.His360Tyr | p.H360Y | Q496Y0 | protein_coding | tolerated(0.45) | benign(0.186) | TCGA-34-5928-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LONRF3 | SNV | Missense_Mutation | rs747526914 | c.1402G>A | p.Ala468Thr | p.A468T | Q496Y0 | protein_coding | deleterious(0.01) | benign(0.074) | TCGA-60-2719-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LONRF3 | SNV | Missense_Mutation | c.1915N>T | p.His639Tyr | p.H639Y | Q496Y0 | protein_coding | tolerated(0.09) | benign(0.426) | TCGA-66-2781-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LONRF3 | SNV | Missense_Mutation | novel | c.2027N>T | p.Gln676Leu | p.Q676L | Q496Y0 | protein_coding | deleterious(0) | benign(0.062) | TCGA-85-8355-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LONRF3 | SNV | Missense_Mutation | novel | c.2228G>A | p.Arg743Lys | p.R743K | Q496Y0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LONRF3 | SNV | Missense_Mutation | c.1402N>T | p.Ala468Ser | p.A468S | Q496Y0 | protein_coding | tolerated(1) | benign(0.005) | TCGA-BA-A6DA-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
LONRF3 | SNV | Missense_Mutation | novel | c.623N>T | p.Arg208Leu | p.R208L | Q496Y0 | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-CV-7099-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LONRF3 | SNV | Missense_Mutation | rs778134653 | c.1381G>A | p.Asp461Asn | p.D461N | Q496Y0 | protein_coding | deleterious(0.03) | possibly_damaging(0.849) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LONRF3 | SNV | Missense_Mutation | c.1110N>T | p.Arg370Ser | p.R370S | Q496Y0 | protein_coding | tolerated(0.79) | benign(0) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LONRF3 | SNV | Missense_Mutation | c.1706N>A | p.Pro569His | p.P569H | Q496Y0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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