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Gene: LMBRD1 |
Gene summary for LMBRD1 |
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Gene information | Species | Human | Gene symbol | LMBRD1 | Gene ID | 55788 |
Gene name | LMBR1 domain containing 1 | |
Gene Alias | C6orf209 | |
Cytomap | 6q13 | |
Gene Type | protein-coding | GO ID | GO:0006725 | UniProtAcc | Q9NUN5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55788 | LMBRD1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.26e-08 | -4.68e-01 | 0.0155 |
55788 | LMBRD1 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.19e-06 | -3.41e-01 | -0.1464 |
55788 | LMBRD1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.15e-03 | -3.75e-01 | 0.096 |
55788 | LMBRD1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.52e-05 | -3.71e-01 | 0.0674 |
55788 | LMBRD1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.18e-08 | -3.87e-01 | 0.3005 |
55788 | LMBRD1 | A002-C-010 | Human | Colorectum | FAP | 5.84e-06 | -2.36e-01 | 0.242 |
55788 | LMBRD1 | A001-C-207 | Human | Colorectum | FAP | 3.84e-05 | -3.98e-01 | 0.1278 |
55788 | LMBRD1 | A015-C-203 | Human | Colorectum | FAP | 1.98e-23 | -4.71e-01 | -0.1294 |
55788 | LMBRD1 | A015-C-204 | Human | Colorectum | FAP | 3.51e-06 | -4.04e-01 | -0.0228 |
55788 | LMBRD1 | A014-C-040 | Human | Colorectum | FAP | 7.46e-03 | -4.29e-01 | -0.1184 |
55788 | LMBRD1 | A002-C-201 | Human | Colorectum | FAP | 2.18e-10 | -3.91e-01 | 0.0324 |
55788 | LMBRD1 | A002-C-203 | Human | Colorectum | FAP | 3.39e-04 | -2.14e-01 | 0.2786 |
55788 | LMBRD1 | A001-C-119 | Human | Colorectum | FAP | 1.18e-11 | -5.46e-01 | -0.1557 |
55788 | LMBRD1 | A001-C-108 | Human | Colorectum | FAP | 5.01e-20 | -4.17e-01 | -0.0272 |
55788 | LMBRD1 | A002-C-205 | Human | Colorectum | FAP | 5.09e-17 | -4.93e-01 | -0.1236 |
55788 | LMBRD1 | A001-C-104 | Human | Colorectum | FAP | 1.81e-09 | -3.98e-01 | 0.0184 |
55788 | LMBRD1 | A015-C-005 | Human | Colorectum | FAP | 8.81e-07 | -3.63e-01 | -0.0336 |
55788 | LMBRD1 | A015-C-006 | Human | Colorectum | FAP | 5.65e-12 | -5.00e-01 | -0.0994 |
55788 | LMBRD1 | A015-C-106 | Human | Colorectum | FAP | 5.41e-13 | -3.61e-01 | -0.0511 |
55788 | LMBRD1 | A002-C-114 | Human | Colorectum | FAP | 9.39e-15 | -4.77e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043112 | Colorectum | AD | receptor metabolic process | 62/3918 | 166/18723 | 8.18e-07 | 2.85e-05 | 62 |
GO:0072583 | Colorectum | AD | clathrin-dependent endocytosis | 24/3918 | 47/18723 | 4.60e-06 | 1.22e-04 | 24 |
GO:0006898 | Colorectum | AD | receptor-mediated endocytosis | 76/3918 | 244/18723 | 1.07e-04 | 1.59e-03 | 76 |
GO:0072665 | Colorectum | AD | protein localization to vacuole | 27/3918 | 67/18723 | 2.40e-04 | 3.04e-03 | 27 |
GO:0061462 | Colorectum | AD | protein localization to lysosome | 19/3918 | 46/18723 | 1.36e-03 | 1.19e-02 | 19 |
GO:0007369 | Colorectum | AD | gastrulation | 53/3918 | 185/18723 | 7.60e-03 | 4.60e-02 | 53 |
GO:0031623 | Colorectum | AD | receptor internalization | 35/3918 | 113/18723 | 7.72e-03 | 4.66e-02 | 35 |
GO:00431121 | Colorectum | MSS | receptor metabolic process | 57/3467 | 166/18723 | 8.47e-07 | 2.97e-05 | 57 |
GO:00725831 | Colorectum | MSS | clathrin-dependent endocytosis | 22/3467 | 47/18723 | 8.74e-06 | 2.16e-04 | 22 |
GO:00068981 | Colorectum | MSS | receptor-mediated endocytosis | 69/3467 | 244/18723 | 1.18e-04 | 1.82e-03 | 69 |
GO:00726652 | Colorectum | MSS | protein localization to vacuole | 23/3467 | 67/18723 | 1.51e-03 | 1.39e-02 | 23 |
GO:00316231 | Colorectum | MSS | receptor internalization | 32/3467 | 113/18723 | 7.02e-03 | 4.50e-02 | 32 |
GO:00725832 | Colorectum | FAP | clathrin-dependent endocytosis | 21/2622 | 47/18723 | 3.45e-07 | 1.87e-05 | 21 |
GO:00068982 | Colorectum | FAP | receptor-mediated endocytosis | 62/2622 | 244/18723 | 1.47e-06 | 6.39e-05 | 62 |
GO:00431122 | Colorectum | FAP | receptor metabolic process | 46/2622 | 166/18723 | 2.70e-06 | 1.02e-04 | 46 |
GO:00073692 | Colorectum | FAP | gastrulation | 42/2622 | 185/18723 | 8.97e-04 | 9.10e-03 | 42 |
GO:00316232 | Colorectum | FAP | receptor internalization | 28/2622 | 113/18723 | 1.56e-03 | 1.39e-02 | 28 |
GO:00725833 | Colorectum | CRC | clathrin-dependent endocytosis | 18/2078 | 47/18723 | 1.16e-06 | 6.75e-05 | 18 |
GO:00068983 | Colorectum | CRC | receptor-mediated endocytosis | 50/2078 | 244/18723 | 1.27e-05 | 4.08e-04 | 50 |
GO:00431123 | Colorectum | CRC | receptor metabolic process | 36/2078 | 166/18723 | 5.86e-05 | 1.31e-03 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LMBRD1 | SNV | Missense_Mutation | c.119N>T | p.Arg40Leu | p.R40L | Q9NUN5 | protein_coding | deleterious(0.04) | benign(0.216) | TCGA-CR-7402-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
LMBRD1 | SNV | Missense_Mutation | novel | c.1464N>T | p.Trp488Cys | p.W488C | Q9NUN5 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-IQ-A6SG-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
LMBRD1 | SNV | Missense_Mutation | c.632N>G | p.Tyr211Cys | p.Y211C | Q9NUN5 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-EJ-7786-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
LMBRD1 | SNV | Missense_Mutation | c.1235N>G | p.Phe412Cys | p.F412C | Q9NUN5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B7-5818-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
LMBRD1 | SNV | Missense_Mutation | rs747354714 | c.830N>A | p.Arg277Gln | p.R277Q | Q9NUN5 | protein_coding | tolerated(0.19) | benign(0.031) | TCGA-BR-4257-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LMBRD1 | SNV | Missense_Mutation | novel | c.656T>C | p.Leu219Ser | p.L219S | Q9NUN5 | protein_coding | deleterious(0) | possibly_damaging(0.864) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LMBRD1 | SNV | Missense_Mutation | c.328T>C | p.Phe110Leu | p.F110L | Q9NUN5 | protein_coding | tolerated(0.33) | benign(0.001) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LMBRD1 | SNV | Missense_Mutation | c.805N>G | p.Leu269Val | p.L269V | Q9NUN5 | protein_coding | tolerated(0.18) | benign(0.104) | TCGA-BR-7197-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LMBRD1 | SNV | Missense_Mutation | c.647N>C | p.Met216Thr | p.M216T | Q9NUN5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LMBRD1 | SNV | Missense_Mutation | c.1342A>G | p.Asn448Asp | p.N448D | Q9NUN5 | protein_coding | tolerated(0.2) | benign(0.071) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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