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Gene: LINGO1 |
Gene summary for LINGO1 |
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Gene information | Species | Human | Gene symbol | LINGO1 | Gene ID | 84894 |
Gene name | leucine rich repeat and Ig domain containing 1 | |
Gene Alias | LERN1 | |
Cytomap | 15q24.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96FE5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84894 | LINGO1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.02e-08 | -5.02e-01 | 0.0155 |
84894 | LINGO1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.47e-02 | 3.37e-01 | 0.0216 |
84894 | LINGO1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.89e-05 | -2.35e-01 | -0.1088 |
84894 | LINGO1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.73e-07 | -2.81e-01 | -0.1954 |
84894 | LINGO1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.96e-12 | 7.14e-01 | -0.1207 |
84894 | LINGO1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.28e-06 | 9.97e-02 | -0.1001 |
84894 | LINGO1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.94e-02 | 5.66e-02 | -0.059 |
84894 | LINGO1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.59e-05 | -4.63e-01 | 0.096 |
84894 | LINGO1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.24e-03 | -6.45e-01 | -0.0177 |
84894 | LINGO1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.35e-05 | -5.92e-01 | 0.0338 |
84894 | LINGO1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.82e-15 | -5.97e-01 | 0.0674 |
84894 | LINGO1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.55e-04 | -3.92e-01 | 0.0588 |
84894 | LINGO1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.05e-14 | -5.43e-01 | 0.294 |
84894 | LINGO1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.53e-03 | 5.24e-01 | 0.3487 |
84894 | LINGO1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.37e-07 | -6.45e-01 | 0.281 |
84894 | LINGO1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.98e-14 | -5.73e-01 | 0.3859 |
84894 | LINGO1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.31e-10 | -3.98e-01 | 0.3005 |
84894 | LINGO1 | A015-C-203 | Human | Colorectum | FAP | 6.02e-52 | 1.02e+00 | -0.1294 |
84894 | LINGO1 | A015-C-204 | Human | Colorectum | FAP | 5.76e-20 | 8.34e-01 | -0.0228 |
84894 | LINGO1 | A014-C-040 | Human | Colorectum | FAP | 1.43e-27 | 1.27e+00 | -0.1184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LINGO1 | SNV | Missense_Mutation | novel | c.1650N>A | p.Phe550Leu | p.F550L | Q96FE5 | protein_coding | tolerated(0.17) | benign(0.013) | TCGA-DD-A1EE-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
LINGO1 | SNV | Missense_Mutation | c.574A>C | p.Ser192Arg | p.S192R | Q96FE5 | protein_coding | tolerated(0.14) | possibly_damaging(0.619) | TCGA-ED-A459-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Ancillary | alvesin | CR | |
LINGO1 | SNV | Missense_Mutation | c.868C>A | p.Arg290Ser | p.R290S | Q96FE5 | protein_coding | tolerated(0.3) | possibly_damaging(0.568) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
LINGO1 | SNV | Missense_Mutation | c.1253A>G | p.Tyr418Cys | p.Y418C | Q96FE5 | protein_coding | deleterious(0.01) | possibly_damaging(0.905) | TCGA-44-8117-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
LINGO1 | SNV | Missense_Mutation | c.1418N>T | p.Arg473Leu | p.R473L | Q96FE5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
LINGO1 | SNV | Missense_Mutation | c.1358C>A | p.Pro453Gln | p.P453Q | Q96FE5 | protein_coding | tolerated(0.35) | benign(0.03) | TCGA-55-7995-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
LINGO1 | SNV | Missense_Mutation | c.1078A>T | p.Asn360Tyr | p.N360Y | Q96FE5 | protein_coding | deleterious(0.02) | possibly_damaging(0.807) | TCGA-55-8620-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
LINGO1 | SNV | Missense_Mutation | c.989N>A | p.Ala330Asp | p.A330D | Q96FE5 | protein_coding | deleterious(0) | possibly_damaging(0.881) | TCGA-64-1676-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
LINGO1 | SNV | Missense_Mutation | c.1799N>T | p.Arg600Leu | p.R600L | Q96FE5 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-69-7764-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LINGO1 | SNV | Missense_Mutation | c.892N>A | p.Pro298Thr | p.P298T | Q96FE5 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-97-A4M7-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
84894 | LINGO1 | DRUGGABLE GENOME | antibody | 310264704 | OPICINUMAB | |
84894 | LINGO1 | DRUGGABLE GENOME | inhibitor | CHEMBL3544922 | OPICINUMAB | |
84894 | LINGO1 | DRUGGABLE GENOME | BIIB-033 | OPICINUMAB |
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