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Gene: LGR5 |
Gene summary for LGR5 |
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Gene information | Species | Human | Gene symbol | LGR5 | Gene ID | 8549 |
Gene name | leucine rich repeat containing G protein-coupled receptor 5 | |
Gene Alias | FEX | |
Cytomap | 12q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O75473 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8549 | LGR5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.63e-10 | 6.91e-01 | 0.0155 |
8549 | LGR5 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.75e-04 | 9.37e-01 | 0.0216 |
8549 | LGR5 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.76e-04 | -2.88e-01 | -0.1954 |
8549 | LGR5 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.27e-20 | 9.94e-01 | 0.096 |
8549 | LGR5 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.15e-02 | 8.35e-01 | 0.0451 |
8549 | LGR5 | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.38e-03 | 1.11e+00 | 0.0131 |
8549 | LGR5 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.59e-05 | 7.21e-01 | 0.0338 |
8549 | LGR5 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.57e-30 | 1.31e+00 | 0.0674 |
8549 | LGR5 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.46e-06 | 1.13e+00 | 0.0112 |
8549 | LGR5 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.12e-31 | 1.72e+00 | 0.0588 |
8549 | LGR5 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.20e-26 | 9.92e-01 | 0.294 |
8549 | LGR5 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.86e-08 | 2.39e+00 | 0.3487 |
8549 | LGR5 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.69e-25 | 1.76e+00 | 0.281 |
8549 | LGR5 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.84e-02 | 7.11e-02 | 0.3005 |
8549 | LGR5 | F007 | Human | Colorectum | FAP | 1.69e-03 | 6.84e-01 | 0.1176 |
8549 | LGR5 | A002-C-010 | Human | Colorectum | FAP | 2.25e-24 | 9.24e-01 | 0.242 |
8549 | LGR5 | A001-C-207 | Human | Colorectum | FAP | 2.16e-15 | 9.55e-01 | 0.1278 |
8549 | LGR5 | A015-C-203 | Human | Colorectum | FAP | 4.13e-09 | 7.02e-01 | -0.1294 |
8549 | LGR5 | A002-C-201 | Human | Colorectum | FAP | 8.74e-05 | 6.15e-01 | 0.0324 |
8549 | LGR5 | A002-C-203 | Human | Colorectum | FAP | 1.95e-16 | 8.49e-01 | 0.2786 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030111 | Colorectum | AD | regulation of Wnt signaling pathway | 102/3918 | 328/18723 | 8.51e-06 | 2.03e-04 | 102 |
GO:0016055 | Colorectum | AD | Wnt signaling pathway | 130/3918 | 444/18723 | 1.60e-05 | 3.37e-04 | 130 |
GO:0198738 | Colorectum | AD | cell-cell signaling by wnt | 130/3918 | 446/18723 | 2.02e-05 | 4.10e-04 | 130 |
GO:0009755 | Colorectum | AD | hormone-mediated signaling pathway | 64/3918 | 190/18723 | 2.78e-05 | 5.24e-04 | 64 |
GO:0060070 | Colorectum | AD | canonical Wnt signaling pathway | 90/3918 | 303/18723 | 1.76e-04 | 2.38e-03 | 90 |
GO:0060828 | Colorectum | AD | regulation of canonical Wnt signaling pathway | 77/3918 | 253/18723 | 2.19e-04 | 2.87e-03 | 77 |
GO:0060562 | Colorectum | AD | epithelial tube morphogenesis | 93/3918 | 325/18723 | 5.65e-04 | 6.00e-03 | 93 |
GO:0050673 | Colorectum | AD | epithelial cell proliferation | 119/3918 | 437/18723 | 8.75e-04 | 8.51e-03 | 119 |
GO:0030177 | Colorectum | AD | positive regulation of Wnt signaling pathway | 45/3918 | 140/18723 | 1.23e-03 | 1.09e-02 | 45 |
GO:0008544 | Colorectum | AD | epidermis development | 87/3918 | 324/18723 | 5.99e-03 | 3.76e-02 | 87 |
GO:00097551 | Colorectum | SER | hormone-mediated signaling pathway | 49/2897 | 190/18723 | 1.54e-04 | 3.00e-03 | 49 |
GO:00160551 | Colorectum | SER | Wnt signaling pathway | 97/2897 | 444/18723 | 2.02e-04 | 3.68e-03 | 97 |
GO:01987381 | Colorectum | SER | cell-cell signaling by wnt | 97/2897 | 446/18723 | 2.39e-04 | 4.11e-03 | 97 |
GO:00301111 | Colorectum | SER | regulation of Wnt signaling pathway | 75/2897 | 328/18723 | 2.47e-04 | 4.20e-03 | 75 |
GO:00600701 | Colorectum | SER | canonical Wnt signaling pathway | 66/2897 | 303/18723 | 2.10e-03 | 2.06e-02 | 66 |
GO:00608281 | Colorectum | SER | regulation of canonical Wnt signaling pathway | 56/2897 | 253/18723 | 3.03e-03 | 2.67e-02 | 56 |
GO:0090263 | Colorectum | SER | positive regulation of canonical Wnt signaling pathway | 27/2897 | 106/18723 | 5.12e-03 | 3.92e-02 | 27 |
GO:00301112 | Colorectum | MSS | regulation of Wnt signaling pathway | 98/3467 | 328/18723 | 3.37e-07 | 1.36e-05 | 98 |
GO:00160552 | Colorectum | MSS | Wnt signaling pathway | 124/3467 | 444/18723 | 6.06e-07 | 2.26e-05 | 124 |
GO:01987382 | Colorectum | MSS | cell-cell signaling by wnt | 124/3467 | 446/18723 | 7.83e-07 | 2.77e-05 | 124 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04310 | Colorectum | AD | Wnt signaling pathway | 56/2092 | 171/8465 | 1.03e-02 | 3.93e-02 | 2.51e-02 | 56 |
hsa043101 | Colorectum | AD | Wnt signaling pathway | 56/2092 | 171/8465 | 1.03e-02 | 3.93e-02 | 2.51e-02 | 56 |
hsa043102 | Colorectum | MSS | Wnt signaling pathway | 53/1875 | 171/8465 | 4.24e-03 | 1.86e-02 | 1.14e-02 | 53 |
hsa043103 | Colorectum | MSS | Wnt signaling pathway | 53/1875 | 171/8465 | 4.24e-03 | 1.86e-02 | 1.14e-02 | 53 |
hsa043104 | Colorectum | FAP | Wnt signaling pathway | 46/1404 | 171/8465 | 3.94e-04 | 3.06e-03 | 1.86e-03 | 46 |
hsa043105 | Colorectum | FAP | Wnt signaling pathway | 46/1404 | 171/8465 | 3.94e-04 | 3.06e-03 | 1.86e-03 | 46 |
hsa043106 | Colorectum | CRC | Wnt signaling pathway | 40/1091 | 171/8465 | 1.01e-04 | 1.57e-03 | 1.07e-03 | 40 |
hsa043107 | Colorectum | CRC | Wnt signaling pathway | 40/1091 | 171/8465 | 1.01e-04 | 1.57e-03 | 1.07e-03 | 40 |
hsa0431010 | Endometrium | AEH | Wnt signaling pathway | 37/1197 | 171/8465 | 4.68e-03 | 2.53e-02 | 1.86e-02 | 37 |
hsa0431013 | Endometrium | AEH | Wnt signaling pathway | 37/1197 | 171/8465 | 4.68e-03 | 2.53e-02 | 1.86e-02 | 37 |
hsa0431022 | Endometrium | EEC | Wnt signaling pathway | 40/1237 | 171/8465 | 1.37e-03 | 8.99e-03 | 6.70e-03 | 40 |
hsa0431032 | Endometrium | EEC | Wnt signaling pathway | 40/1237 | 171/8465 | 1.37e-03 | 8.99e-03 | 6.70e-03 | 40 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LGR5 | SNV | Missense_Mutation | novel | c.1224C>A | p.Asn408Lys | p.N408K | O75473 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-8508-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LGR5 | SNV | Missense_Mutation | c.1751N>A | p.Arg584Lys | p.R584K | O75473 | protein_coding | tolerated(0.19) | benign(0.158) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LGR5 | SNV | Missense_Mutation | c.2325N>A | p.Asn775Lys | p.N775K | O75473 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-78-7220-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
LGR5 | SNV | Missense_Mutation | c.1988N>C | p.Gly663Ala | p.G663A | O75473 | protein_coding | tolerated(0.31) | benign(0.029) | TCGA-86-7701-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | etoposide | PD | |
LGR5 | SNV | Missense_Mutation | c.494N>A | p.Arg165Lys | p.R165K | O75473 | protein_coding | tolerated(0.09) | probably_damaging(0.999) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
LGR5 | SNV | Missense_Mutation | c.761N>T | p.Arg254Met | p.R254M | O75473 | protein_coding | deleterious(0) | probably_damaging(0.923) | TCGA-91-6829-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LGR5 | SNV | Missense_Mutation | c.158N>G | p.Ser53Cys | p.S53C | O75473 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-93-8067-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LGR5 | SNV | Missense_Mutation | novel | c.338T>A | p.Leu113His | p.L113H | O75473 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-NJ-A4YF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LGR5 | SNV | Missense_Mutation | novel | c.1427C>A | p.Ala476Asp | p.A476D | O75473 | protein_coding | deleterious(0) | probably_damaging(0.938) | TCGA-NJ-A55R-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LGR5 | SNV | Missense_Mutation | c.2104G>A | p.Gly702Ser | p.G702S | O75473 | protein_coding | tolerated(1) | benign(0.006) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8549 | LGR5 | G PROTEIN COUPLED RECEPTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | fluorouracil | FLUOROURACIL | 25665511 | |
8549 | LGR5 | G PROTEIN COUPLED RECEPTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | agonist | 178100588 | ||
8549 | LGR5 | G PROTEIN COUPLED RECEPTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | agonist | 178100587 | ||
8549 | LGR5 | G PROTEIN COUPLED RECEPTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | agonist | 178100586 | ||
8549 | LGR5 | G PROTEIN COUPLED RECEPTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | agonist | 178100589 |
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