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Gene: LCORL |
Gene summary for LCORL |
Gene summary. |
Gene information | Species | Human | Gene symbol | LCORL | Gene ID | 254251 |
Gene name | ligand dependent nuclear receptor corepressor like | |
Gene Alias | MLR1 | |
Cytomap | 4p15.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8N3X6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
254251 | LCORL | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.51e-17 | -6.42e-01 | 0.0155 |
254251 | LCORL | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.32e-04 | -4.76e-01 | -0.1808 |
254251 | LCORL | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.09e-03 | -5.06e-01 | -0.1207 |
254251 | LCORL | HTA11_83_2000001011 | Human | Colorectum | SER | 5.55e-03 | -4.54e-01 | -0.1526 |
254251 | LCORL | HTA11_696_2000001011 | Human | Colorectum | AD | 5.99e-11 | -4.14e-01 | -0.1464 |
254251 | LCORL | HTA11_866_3004761011 | Human | Colorectum | AD | 4.52e-12 | -5.98e-01 | 0.096 |
254251 | LCORL | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.33e-03 | -5.69e-01 | 0.0528 |
254251 | LCORL | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.19e-02 | -4.93e-01 | 0.0338 |
254251 | LCORL | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.32e-20 | -5.24e-01 | 0.0674 |
254251 | LCORL | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.34e-04 | -6.09e-01 | 0.0588 |
254251 | LCORL | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.83e-11 | -4.47e-01 | 0.294 |
254251 | LCORL | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.95e-16 | -5.15e-01 | 0.3859 |
254251 | LCORL | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.68e-09 | -7.69e-01 | 0.2585 |
254251 | LCORL | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.74e-22 | -6.24e-01 | 0.3005 |
254251 | LCORL | A001-C-207 | Human | Colorectum | FAP | 1.00e-05 | -4.04e-01 | 0.1278 |
254251 | LCORL | A015-C-203 | Human | Colorectum | FAP | 2.95e-36 | -5.99e-01 | -0.1294 |
254251 | LCORL | A015-C-204 | Human | Colorectum | FAP | 6.96e-07 | -4.21e-01 | -0.0228 |
254251 | LCORL | A014-C-040 | Human | Colorectum | FAP | 8.21e-05 | -3.88e-01 | -0.1184 |
254251 | LCORL | A002-C-201 | Human | Colorectum | FAP | 7.88e-17 | -4.54e-01 | 0.0324 |
254251 | LCORL | A002-C-203 | Human | Colorectum | FAP | 7.62e-05 | -2.77e-01 | 0.2786 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LCORL | SNV | Missense_Mutation | rs867841298 | c.1004N>T | p.Ser335Leu | p.S335L | Q8N3X6 | protein_coding | tolerated(0.26) | benign(0) | TCGA-DD-A4NE-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | sorafenib | PD |
LCORL | SNV | Missense_Mutation | novel | c.1457C>G | p.Pro486Arg | p.P486R | Q8N3X6 | protein_coding | deleterious(0.02) | probably_damaging(0.973) | TCGA-G3-AAV0-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LCORL | SNV | Missense_Mutation | novel | c.595N>G | p.Asn199Asp | p.N199D | Q8N3X6 | protein_coding | tolerated(0.11) | benign(0.156) | TCGA-WQ-A9G7-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
LCORL | SNV | Missense_Mutation | c.530N>T | p.Gly177Val | p.G177V | Q8N3X6 | protein_coding | tolerated(0.3) | benign(0.188) | TCGA-64-5778-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Targeted Molecular therapy | tarceva | PD | |
LCORL | SNV | Missense_Mutation | rs780294822 | c.697N>C | p.Asp233His | p.D233H | Q8N3X6 | protein_coding | deleterious(0) | benign(0.046) | TCGA-34-8455-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
LCORL | SNV | Missense_Mutation | novel | c.5193N>C | p.Leu1731Phe | p.L1731F | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-60-2698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | mithramycin | PD | |
LCORL | SNV | Missense_Mutation | novel | c.4945C>T | p.Pro1649Ser | p.P1649S | protein_coding | tolerated(0.19) | benign(0.048) | TCGA-60-2720-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
LCORL | SNV | Missense_Mutation | novel | c.767N>T | p.Ser256Leu | p.S256L | Q8N3X6 | protein_coding | tolerated(0.25) | benign(0.039) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
LCORL | SNV | Missense_Mutation | novel | c.343N>C | p.Glu115Gln | p.E115Q | Q8N3X6 | protein_coding | deleterious(0.04) | possibly_damaging(0.478) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
LCORL | SNV | Missense_Mutation | c.623N>T | p.Glu208Val | p.E208V | Q8N3X6 | protein_coding | deleterious(0.03) | probably_damaging(0.962) | TCGA-CV-6956-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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