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Gene: KIF26B |
Gene summary for KIF26B |
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Gene information | Species | Human | Gene symbol | KIF26B | Gene ID | 55083 |
Gene name | kinesin family member 26B | |
Gene Alias | KIF26B | |
Cytomap | 1q44 | |
Gene Type | protein-coding | GO ID | GO:0001655 | UniProtAcc | Q2KJY2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55083 | KIF26B | HTA11_347_2000001011 | Human | Colorectum | AD | 2.00e-04 | 1.66e-01 | -0.1954 |
55083 | KIF26B | HTA11_866_3004761011 | Human | Colorectum | AD | 4.21e-14 | 5.98e-01 | 0.096 |
55083 | KIF26B | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.00e-05 | 4.28e-01 | 0.0112 |
55083 | KIF26B | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.50e-18 | 8.63e-01 | 0.0588 |
55083 | KIF26B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.59e-04 | 1.98e-01 | 0.294 |
55083 | KIF26B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.15e-07 | 2.97e-01 | 0.3859 |
55083 | KIF26B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.17e-06 | 2.26e-01 | 0.3005 |
55083 | KIF26B | A001-C-007 | Human | Colorectum | CRC | 5.42e-09 | 6.37e-01 | 0.1899 |
55083 | KIF26B | AEH-subject1 | Human | Endometrium | AEH | 7.61e-13 | 3.96e-01 | -0.3059 |
55083 | KIF26B | AEH-subject2 | Human | Endometrium | AEH | 1.49e-08 | 3.68e-01 | -0.2525 |
55083 | KIF26B | AEH-subject4 | Human | Endometrium | AEH | 7.13e-09 | 4.20e-01 | -0.2657 |
55083 | KIF26B | EEC-subject1 | Human | Endometrium | EEC | 7.32e-16 | 5.46e-01 | -0.2682 |
55083 | KIF26B | EEC-subject2 | Human | Endometrium | EEC | 4.31e-10 | 4.07e-01 | -0.2607 |
55083 | KIF26B | EEC-subject3 | Human | Endometrium | EEC | 3.77e-14 | 5.37e-01 | -0.2525 |
55083 | KIF26B | EEC-subject4 | Human | Endometrium | EEC | 2.44e-05 | 2.74e-01 | -0.2571 |
55083 | KIF26B | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 4.23e-03 | 8.97e-02 | -0.1869 |
55083 | KIF26B | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.77e-02 | 9.42e-02 | -0.1875 |
55083 | KIF26B | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 2.84e-04 | 7.33e-02 | -0.1883 |
55083 | KIF26B | HCC2_Meng | Human | Liver | HCC | 3.57e-03 | 7.12e-02 | 0.0107 |
55083 | KIF26B | S014 | Human | Liver | HCC | 2.32e-34 | 1.11e+00 | 0.2254 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007163 | Colorectum | AD | establishment or maintenance of cell polarity | 77/3918 | 218/18723 | 5.72e-07 | 2.08e-05 | 77 |
GO:0030010 | Colorectum | AD | establishment of cell polarity | 50/3918 | 143/18723 | 6.90e-05 | 1.11e-03 | 50 |
GO:0045785 | Colorectum | AD | positive regulation of cell adhesion | 122/3918 | 437/18723 | 2.65e-04 | 3.28e-03 | 122 |
GO:0060562 | Colorectum | AD | epithelial tube morphogenesis | 93/3918 | 325/18723 | 5.65e-04 | 6.00e-03 | 93 |
GO:0072073 | Colorectum | AD | kidney epithelium development | 42/3918 | 136/18723 | 4.02e-03 | 2.80e-02 | 42 |
GO:0060560 | Colorectum | AD | developmental growth involved in morphogenesis | 66/3918 | 234/18723 | 4.75e-03 | 3.22e-02 | 66 |
GO:00071632 | Colorectum | MSS | establishment or maintenance of cell polarity | 72/3467 | 218/18723 | 1.90e-07 | 8.30e-06 | 72 |
GO:00300102 | Colorectum | MSS | establishment of cell polarity | 47/3467 | 143/18723 | 2.74e-05 | 5.58e-04 | 47 |
GO:00605621 | Colorectum | MSS | epithelial tube morphogenesis | 88/3467 | 325/18723 | 8.45e-05 | 1.37e-03 | 88 |
GO:00457852 | Colorectum | MSS | positive regulation of cell adhesion | 110/3467 | 437/18723 | 2.94e-04 | 3.87e-03 | 110 |
GO:00605601 | Colorectum | MSS | developmental growth involved in morphogenesis | 61/3467 | 234/18723 | 2.56e-03 | 2.03e-02 | 61 |
GO:00720731 | Colorectum | MSS | kidney epithelium development | 38/3467 | 136/18723 | 4.53e-03 | 3.19e-02 | 38 |
GO:0001655 | Colorectum | MSS | urogenital system development | 81/3467 | 338/18723 | 6.88e-03 | 4.43e-02 | 81 |
GO:00071634 | Colorectum | CRC | establishment or maintenance of cell polarity | 57/2078 | 218/18723 | 3.96e-10 | 1.58e-07 | 57 |
GO:00300104 | Colorectum | CRC | establishment of cell polarity | 40/2078 | 143/18723 | 2.09e-08 | 3.23e-06 | 40 |
GO:00605603 | Colorectum | CRC | developmental growth involved in morphogenesis | 53/2078 | 234/18723 | 2.88e-07 | 2.54e-05 | 53 |
GO:00457855 | Colorectum | CRC | positive regulation of cell adhesion | 81/2078 | 437/18723 | 2.28e-06 | 1.10e-04 | 81 |
GO:00720733 | Colorectum | CRC | kidney epithelium development | 34/2078 | 136/18723 | 3.87e-06 | 1.63e-04 | 34 |
GO:00016552 | Colorectum | CRC | urogenital system development | 62/2078 | 338/18723 | 4.67e-05 | 1.10e-03 | 62 |
GO:00720011 | Colorectum | CRC | renal system development | 56/2078 | 302/18723 | 7.85e-05 | 1.63e-03 | 56 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa048144 | Endometrium | AEH | Motor proteins | 42/1197 | 193/8465 | 2.41e-03 | 1.42e-02 | 1.04e-02 | 42 |
hsa0481411 | Endometrium | AEH | Motor proteins | 42/1197 | 193/8465 | 2.41e-03 | 1.42e-02 | 1.04e-02 | 42 |
hsa048142 | Endometrium | EEC | Motor proteins | 42/1237 | 193/8465 | 4.43e-03 | 2.39e-02 | 1.78e-02 | 42 |
hsa048143 | Endometrium | EEC | Motor proteins | 42/1237 | 193/8465 | 4.43e-03 | 2.39e-02 | 1.78e-02 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF26B | SNV | Missense_Mutation | rs567573827 | c.3100G>A | p.Ala1034Thr | p.A1034T | Q2KJY2 | protein_coding | tolerated(0.18) | benign(0) | TCGA-T9-A92H-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KIF26B | SNV | Missense_Mutation | rs532207390 | c.628G>A | p.Gly210Ser | p.G210S | Q2KJY2 | protein_coding | tolerated(1) | benign(0.006) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIF26B | SNV | Missense_Mutation | c.5504C>G | p.Ala1835Gly | p.A1835G | Q2KJY2 | protein_coding | tolerated(0.4) | benign(0) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KIF26B | SNV | Missense_Mutation | rs769468332 | c.2272G>A | p.Ala758Thr | p.A758T | Q2KJY2 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
KIF26B | SNV | Missense_Mutation | c.3373N>T | p.Arg1125Cys | p.R1125C | Q2KJY2 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-BM-6198-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | SD | |
KIF26B | SNV | Missense_Mutation | c.950G>A | p.Gly317Asp | p.G317D | Q2KJY2 | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KIF26B | SNV | Missense_Mutation | rs200467850 | c.2536N>A | p.Ala846Thr | p.A846T | Q2KJY2 | protein_coding | tolerated(0.34) | benign(0.005) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIF26B | SNV | Missense_Mutation | c.3893T>C | p.Phe1298Ser | p.F1298S | Q2KJY2 | protein_coding | tolerated(0.09) | possibly_damaging(0.905) | TCGA-F5-6810-01 | Colorectum | rectum adenocarcinoma | Unknown | Unknown | I/II | Unknown | Unknown | Unknown | |
KIF26B | SNV | Missense_Mutation | c.3894C>A | p.Phe1298Leu | p.F1298L | Q2KJY2 | protein_coding | tolerated(0.05) | benign(0.048) | TCGA-F5-6810-01 | Colorectum | rectum adenocarcinoma | Unknown | Unknown | I/II | Unknown | Unknown | Unknown | |
KIF26B | SNV | Missense_Mutation | novel | c.3249C>A | p.Ser1083Arg | p.S1083R | Q2KJY2 | protein_coding | tolerated(0.06) | benign(0.006) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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