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Gene: KIF1C |
Gene summary for KIF1C |
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Gene information | Species | Human | Gene symbol | KIF1C | Gene ID | 10749 |
Gene name | kinesin family member 1C | |
Gene Alias | LTXS1 | |
Cytomap | 17p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | O43896 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10749 | KIF1C | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.06e-07 | 2.79e-01 | 0.0155 |
10749 | KIF1C | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.85e-33 | 1.12e+00 | -0.1808 |
10749 | KIF1C | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.30e-16 | 8.67e-01 | -0.0811 |
10749 | KIF1C | HTA11_78_2000001011 | Human | Colorectum | AD | 9.33e-09 | 4.57e-01 | -0.1088 |
10749 | KIF1C | HTA11_347_2000001011 | Human | Colorectum | AD | 1.75e-33 | 9.36e-01 | -0.1954 |
10749 | KIF1C | HTA11_411_2000001011 | Human | Colorectum | SER | 2.93e-10 | 1.39e+00 | -0.2602 |
10749 | KIF1C | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.36e-09 | 1.26e+00 | -0.2196 |
10749 | KIF1C | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.34e-08 | 6.91e-01 | -0.1207 |
10749 | KIF1C | HTA11_83_2000001011 | Human | Colorectum | SER | 7.44e-15 | 9.60e-01 | -0.1526 |
10749 | KIF1C | HTA11_696_2000001011 | Human | Colorectum | AD | 5.95e-31 | 8.94e-01 | -0.1464 |
10749 | KIF1C | HTA11_866_2000001011 | Human | Colorectum | AD | 1.43e-22 | 6.78e-01 | -0.1001 |
10749 | KIF1C | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.15e-21 | 9.30e-01 | -0.059 |
10749 | KIF1C | HTA11_2992_2000001011 | Human | Colorectum | SER | 7.15e-06 | 8.47e-01 | -0.1706 |
10749 | KIF1C | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.00e-16 | 1.05e+00 | -0.2061 |
10749 | KIF1C | HTA11_546_2000001011 | Human | Colorectum | AD | 1.84e-02 | 4.84e-01 | -0.0842 |
10749 | KIF1C | HTA11_866_3004761011 | Human | Colorectum | AD | 4.21e-09 | 4.22e-01 | 0.096 |
10749 | KIF1C | HTA11_7663_2000001011 | Human | Colorectum | SER | 5.55e-03 | 6.76e-01 | 0.0131 |
10749 | KIF1C | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.68e-06 | 7.45e-01 | -0.0177 |
10749 | KIF1C | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.54e-20 | 6.46e-01 | 0.0674 |
10749 | KIF1C | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.40e-02 | 5.05e-01 | 0.0112 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0016482 | Colorectum | AD | cytosolic transport | 68/3918 | 168/18723 | 6.00e-09 | 3.72e-07 | 68 |
GO:0006890 | Colorectum | AD | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 27/3918 | 52/18723 | 7.67e-07 | 2.70e-05 | 27 |
GO:0051650 | Colorectum | AD | establishment of vesicle localization | 57/3918 | 161/18723 | 1.47e-05 | 3.15e-04 | 57 |
GO:0051648 | Colorectum | AD | vesicle localization | 59/3918 | 177/18723 | 7.83e-05 | 1.25e-03 | 59 |
GO:0030705 | Colorectum | AD | cytoskeleton-dependent intracellular transport | 60/3918 | 195/18723 | 7.56e-04 | 7.59e-03 | 60 |
GO:0072384 | Colorectum | AD | organelle transport along microtubule | 28/3918 | 85/18723 | 6.55e-03 | 4.07e-02 | 28 |
GO:00516561 | Colorectum | SER | establishment of organelle localization | 100/2897 | 390/18723 | 1.11e-07 | 6.79e-06 | 100 |
GO:00481931 | Colorectum | SER | Golgi vesicle transport | 79/2897 | 296/18723 | 4.20e-07 | 2.15e-05 | 79 |
GO:00068901 | Colorectum | SER | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 20/2897 | 52/18723 | 4.80e-05 | 1.18e-03 | 20 |
GO:00164821 | Colorectum | SER | cytosolic transport | 46/2897 | 168/18723 | 5.20e-05 | 1.25e-03 | 46 |
GO:00516501 | Colorectum | SER | establishment of vesicle localization | 42/2897 | 161/18723 | 3.38e-04 | 5.35e-03 | 42 |
GO:00516481 | Colorectum | SER | vesicle localization | 43/2897 | 177/18723 | 1.41e-03 | 1.53e-02 | 43 |
GO:00307051 | Colorectum | SER | cytoskeleton-dependent intracellular transport | 44/2897 | 195/18723 | 5.53e-03 | 4.09e-02 | 44 |
GO:00481932 | Colorectum | MSS | Golgi vesicle transport | 101/3467 | 296/18723 | 9.09e-11 | 9.77e-09 | 101 |
GO:00516562 | Colorectum | MSS | establishment of organelle localization | 115/3467 | 390/18723 | 7.30e-08 | 3.67e-06 | 115 |
GO:00164822 | Colorectum | MSS | cytosolic transport | 59/3467 | 168/18723 | 2.29e-07 | 9.79e-06 | 59 |
GO:00068902 | Colorectum | MSS | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 26/3467 | 52/18723 | 2.66e-07 | 1.10e-05 | 26 |
GO:00516502 | Colorectum | MSS | establishment of vesicle localization | 51/3467 | 161/18723 | 3.92e-05 | 7.45e-04 | 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF1C | SNV | Missense_Mutation | rs587777198 | c.505N>T | p.Arg169Trp | p.R169W | O43896 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIF1C | SNV | Missense_Mutation | novel | c.1936N>T | p.Arg646Trp | p.R646W | O43896 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIF1C | SNV | Missense_Mutation | novel | c.1937N>A | p.Arg646Lys | p.R646K | O43896 | protein_coding | tolerated(0.2) | probably_damaging(0.931) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIF1C | SNV | Missense_Mutation | novel | c.953N>T | p.Arg318Leu | p.R318L | O43896 | protein_coding | deleterious(0.02) | probably_damaging(0.992) | TCGA-55-8614-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KIF1C | SNV | Missense_Mutation | novel | c.976A>T | p.Ser326Cys | p.S326C | O43896 | protein_coding | deleterious(0) | possibly_damaging(0.866) | TCGA-71-8520-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
KIF1C | SNV | Missense_Mutation | c.3085C>T | p.Pro1029Ser | p.P1029S | O43896 | protein_coding | tolerated_low_confidence(0.47) | benign(0.026) | TCGA-78-8655-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIF1C | SNV | Missense_Mutation | c.770C>T | p.Ser257Phe | p.S257F | O43896 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KIF1C | SNV | Missense_Mutation | novel | c.538G>T | p.Asp180Tyr | p.D180Y | O43896 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-33-AASB-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KIF1C | SNV | Missense_Mutation | c.1354G>C | p.Ala452Pro | p.A452P | O43896 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-60-2719-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIF1C | SNV | Missense_Mutation | novel | c.2948N>A | p.Ser983Asn | p.S983N | O43896 | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.932) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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