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Gene: KCNJ3 |
Gene summary for KCNJ3 |
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Gene information | Species | Human | Gene symbol | KCNJ3 | Gene ID | 3760 |
Gene name | potassium inwardly rectifying channel subfamily J member 3 | |
Gene Alias | GIRK1 | |
Cytomap | 2q24.1 | |
Gene Type | protein-coding | GO ID | GO:0001508 | UniProtAcc | P48549 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3760 | KCNJ3 | GSM4909291 | Human | Breast | IDC | 3.64e-30 | 7.56e-01 | 0.1753 |
3760 | KCNJ3 | GSM4909307 | Human | Breast | IDC | 3.24e-49 | 9.49e-01 | 0.1569 |
3760 | KCNJ3 | GSM4909308 | Human | Breast | IDC | 6.51e-110 | 1.35e+00 | 0.158 |
3760 | KCNJ3 | NCCBC2 | Human | Breast | DCIS | 6.63e-03 | 5.17e-01 | 0.1554 |
3760 | KCNJ3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.48e-05 | 8.31e-01 | 0.3487 |
3760 | KCNJ3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.11e-07 | 3.90e-01 | 0.281 |
3760 | KCNJ3 | CRC-1-8810 | Human | Colorectum | CRC | 1.14e-33 | 8.39e-01 | 0.6257 |
3760 | KCNJ3 | S43 | Human | Liver | Cirrhotic | 4.33e-03 | -7.72e-02 | -0.0187 |
3760 | KCNJ3 | HCC1_Meng | Human | Liver | HCC | 4.33e-03 | -9.03e-02 | 0.0246 |
3760 | KCNJ3 | cirrhotic2 | Human | Liver | Cirrhotic | 9.14e-03 | -8.87e-02 | 0.0201 |
3760 | KCNJ3 | HCC1 | Human | Liver | HCC | 7.86e-15 | 1.61e+00 | 0.5336 |
3760 | KCNJ3 | HCC2 | Human | Liver | HCC | 7.81e-38 | 2.62e+00 | 0.5341 |
3760 | KCNJ3 | HCC5 | Human | Liver | HCC | 1.96e-15 | 8.02e-01 | 0.4932 |
3760 | KCNJ3 | Pt13.a | Human | Liver | HCC | 9.14e-03 | -9.16e-02 | 0.021 |
3760 | KCNJ3 | HTA12-15-2 | Human | Pancreas | PDAC | 4.27e-03 | 2.47e-01 | 0.2315 |
3760 | KCNJ3 | HTA12-23-1 | Human | Pancreas | PDAC | 1.44e-05 | 5.15e-01 | 0.3405 |
3760 | KCNJ3 | HTA12-25-1 | Human | Pancreas | PDAC | 3.64e-05 | 4.88e-01 | 0.313 |
3760 | KCNJ3 | HTA12-26-1 | Human | Pancreas | PDAC | 9.77e-13 | 6.22e-01 | 0.3728 |
3760 | KCNJ3 | HTA12-29-1 | Human | Pancreas | PDAC | 6.39e-34 | 7.83e-01 | 0.3722 |
3760 | KCNJ3 | HTA12-32-1 | Human | Pancreas | PDAC | 1.46e-03 | 7.34e-01 | 0.3624 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:008606511 | Breast | IDC | cell communication involved in cardiac conduction | 13/1434 | 58/18723 | 3.59e-04 | 5.18e-03 | 13 |
GO:00613373 | Breast | IDC | cardiac conduction | 16/1434 | 98/18723 | 3.06e-03 | 2.60e-02 | 16 |
GO:00423912 | Breast | IDC | regulation of membrane potential | 49/1434 | 434/18723 | 4.04e-03 | 3.25e-02 | 49 |
GO:00860015 | Breast | IDC | cardiac muscle cell action potential | 13/1434 | 76/18723 | 4.81e-03 | 3.67e-02 | 13 |
GO:00020271 | Breast | IDC | regulation of heart rate | 16/1434 | 103/18723 | 5.06e-03 | 3.79e-02 | 16 |
GO:00030125 | Breast | IDC | muscle system process | 50/1434 | 452/18723 | 5.52e-03 | 4.05e-02 | 50 |
GO:00015082 | Breast | IDC | action potential | 19/1434 | 134/18723 | 6.62e-03 | 4.62e-02 | 19 |
GO:008606521 | Breast | DCIS | cell communication involved in cardiac conduction | 12/1390 | 58/18723 | 9.71e-04 | 1.08e-02 | 12 |
GO:000301212 | Breast | DCIS | muscle system process | 50/1390 | 452/18723 | 3.02e-03 | 2.57e-02 | 50 |
GO:006133711 | Breast | DCIS | cardiac conduction | 15/1390 | 98/18723 | 5.65e-03 | 4.09e-02 | 15 |
GO:00423911 | Breast | DCIS | regulation of membrane potential | 47/1390 | 434/18723 | 5.87e-03 | 4.20e-02 | 47 |
GO:00300482 | Colorectum | MSS | actin filament-based movement | 44/3467 | 127/18723 | 1.11e-05 | 2.64e-04 | 44 |
GO:0086001 | Colorectum | MSS | cardiac muscle cell action potential | 26/3467 | 76/18723 | 8.18e-04 | 8.59e-03 | 26 |
GO:0086065 | Colorectum | MSS | cell communication involved in cardiac conduction | 21/3467 | 58/18723 | 1.11e-03 | 1.09e-02 | 21 |
GO:0086005 | Colorectum | MSS | ventricular cardiac muscle cell action potential | 14/3467 | 35/18723 | 2.50e-03 | 2.01e-02 | 14 |
GO:0086091 | Colorectum | MSS | regulation of heart rate by cardiac conduction | 15/3467 | 39/18723 | 2.80e-03 | 2.19e-02 | 15 |
GO:0070252 | Colorectum | MSS | actin-mediated cell contraction | 29/3467 | 97/18723 | 4.38e-03 | 3.10e-02 | 29 |
GO:0086003 | Colorectum | MSS | cardiac muscle cell contraction | 23/3467 | 73/18723 | 5.22e-03 | 3.57e-02 | 23 |
GO:00030121 | Colorectum | MSS | muscle system process | 105/3467 | 452/18723 | 6.39e-03 | 4.26e-02 | 105 |
GO:00860651 | Colorectum | MSI-H | cell communication involved in cardiac conduction | 12/1319 | 58/18723 | 6.11e-04 | 1.20e-02 | 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0491523 | Breast | IDC | Estrogen signaling pathway | 35/867 | 138/8465 | 2.55e-07 | 5.18e-06 | 3.88e-06 | 35 |
hsa0472323 | Breast | IDC | Retrograde endocannabinoid signaling | 31/867 | 148/8465 | 7.62e-05 | 7.50e-04 | 5.61e-04 | 31 |
hsa0491533 | Breast | IDC | Estrogen signaling pathway | 35/867 | 138/8465 | 2.55e-07 | 5.18e-06 | 3.88e-06 | 35 |
hsa0472333 | Breast | IDC | Retrograde endocannabinoid signaling | 31/867 | 148/8465 | 7.62e-05 | 7.50e-04 | 5.61e-04 | 31 |
hsa0491542 | Breast | DCIS | Estrogen signaling pathway | 35/846 | 138/8465 | 1.40e-07 | 2.51e-06 | 1.85e-06 | 35 |
hsa0472342 | Breast | DCIS | Retrograde endocannabinoid signaling | 29/846 | 148/8465 | 2.82e-04 | 2.34e-03 | 1.72e-03 | 29 |
hsa0491552 | Breast | DCIS | Estrogen signaling pathway | 35/846 | 138/8465 | 1.40e-07 | 2.51e-06 | 1.85e-06 | 35 |
hsa0472352 | Breast | DCIS | Retrograde endocannabinoid signaling | 29/846 | 148/8465 | 2.82e-04 | 2.34e-03 | 1.72e-03 | 29 |
hsa047234 | Colorectum | MSS | Retrograde endocannabinoid signaling | 61/1875 | 148/8465 | 1.21e-07 | 1.93e-06 | 1.18e-06 | 61 |
hsa049152 | Colorectum | MSS | Estrogen signaling pathway | 48/1875 | 138/8465 | 4.23e-04 | 3.08e-03 | 1.89e-03 | 48 |
hsa047284 | Colorectum | MSS | Dopaminergic synapse | 45/1875 | 132/8465 | 1.02e-03 | 5.94e-03 | 3.64e-03 | 45 |
hsa04713 | Colorectum | MSS | Circadian entrainment | 32/1875 | 97/8465 | 8.84e-03 | 3.25e-02 | 1.99e-02 | 32 |
hsa04725 | Colorectum | MSS | Cholinergic synapse | 36/1875 | 113/8465 | 1.05e-02 | 3.69e-02 | 2.26e-02 | 36 |
hsa047235 | Colorectum | MSS | Retrograde endocannabinoid signaling | 61/1875 | 148/8465 | 1.21e-07 | 1.93e-06 | 1.18e-06 | 61 |
hsa049153 | Colorectum | MSS | Estrogen signaling pathway | 48/1875 | 138/8465 | 4.23e-04 | 3.08e-03 | 1.89e-03 | 48 |
hsa047285 | Colorectum | MSS | Dopaminergic synapse | 45/1875 | 132/8465 | 1.02e-03 | 5.94e-03 | 3.64e-03 | 45 |
hsa047131 | Colorectum | MSS | Circadian entrainment | 32/1875 | 97/8465 | 8.84e-03 | 3.25e-02 | 1.99e-02 | 32 |
hsa047251 | Colorectum | MSS | Cholinergic synapse | 36/1875 | 113/8465 | 1.05e-02 | 3.69e-02 | 2.26e-02 | 36 |
hsa047236 | Colorectum | MSI-H | Retrograde endocannabinoid signaling | 33/797 | 148/8465 | 1.88e-06 | 3.21e-05 | 2.69e-05 | 33 |
hsa047237 | Colorectum | MSI-H | Retrograde endocannabinoid signaling | 33/797 | 148/8465 | 1.88e-06 | 3.21e-05 | 2.69e-05 | 33 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCNJ3 | SNV | Missense_Mutation | c.1290G>T | p.Leu430Phe | p.L430F | P48549 | protein_coding | tolerated_low_confidence(0.06) | benign(0) | TCGA-05-4417-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KCNJ3 | SNV | Missense_Mutation | novel | c.581N>A | p.Leu194His | p.L194H | P48549 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-44-5644-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KCNJ3 | SNV | Missense_Mutation | novel | c.1462N>A | p.Leu488Ile | p.L488I | P48549 | protein_coding | deleterious_low_confidence(0.02) | benign(0.196) | TCGA-44-5644-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KCNJ3 | SNV | Missense_Mutation | c.434N>C | p.Gly145Ala | p.G145A | P48549 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-49-4488-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KCNJ3 | SNV | Missense_Mutation | c.1330N>T | p.Pro444Ser | p.P444S | P48549 | protein_coding | tolerated_low_confidence(0.45) | benign(0) | TCGA-49-4507-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD | |
KCNJ3 | SNV | Missense_Mutation | c.155N>T | p.Arg52Leu | p.R52L | P48549 | protein_coding | deleterious(0.01) | probably_damaging(0.944) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
KCNJ3 | SNV | Missense_Mutation | c.1444N>A | p.Ala482Thr | p.A482T | P48549 | protein_coding | tolerated_low_confidence(0.82) | benign(0.007) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
KCNJ3 | SNV | Missense_Mutation | novel | c.14N>T | p.Arg5Leu | p.R5L | P48549 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-50-5941-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unspecific | Cisplatin | Complete Response |
KCNJ3 | SNV | Missense_Mutation | novel | c.1058C>A | p.Thr353Asn | p.T353N | P48549 | protein_coding | deleterious(0.02) | probably_damaging(0.966) | TCGA-50-5942-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KCNJ3 | SNV | Missense_Mutation | c.859N>T | p.Ser287Cys | p.S287C | P48549 | protein_coding | deleterious(0.01) | possibly_damaging(0.756) | TCGA-55-6969-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3760 | KCNJ3 | EXTERNAL SIDE OF PLASMA MEMBRANE, ION CHANNEL, DRUGGABLE GENOME | activator | 135652743 | ||
3760 | KCNJ3 | EXTERNAL SIDE OF PLASMA MEMBRANE, ION CHANNEL, DRUGGABLE GENOME | activator | 223366101 | ||
3760 | KCNJ3 | EXTERNAL SIDE OF PLASMA MEMBRANE, ION CHANNEL, DRUGGABLE GENOME | blocker | 223366037 | ||
3760 | KCNJ3 | EXTERNAL SIDE OF PLASMA MEMBRANE, ION CHANNEL, DRUGGABLE GENOME | CLOZAPINE | CLOZAPINE | 10780978 | |
3760 | KCNJ3 | EXTERNAL SIDE OF PLASMA MEMBRANE, ION CHANNEL, DRUGGABLE GENOME | FLUPIRTINE | FLUPIRTINE | ||
3760 | KCNJ3 | EXTERNAL SIDE OF PLASMA MEMBRANE, ION CHANNEL, DRUGGABLE GENOME | blocker | 135652729 | ||
3760 | KCNJ3 | EXTERNAL SIDE OF PLASMA MEMBRANE, ION CHANNEL, DRUGGABLE GENOME | THYROTROPIN | THYROTROPIN | 10075694 |
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