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Gene: IVNS1ABP |
Gene summary for IVNS1ABP |
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Gene information | Species | Human | Gene symbol | IVNS1ABP | Gene ID | 10625 |
Gene name | influenza virus NS1A binding protein | |
Gene Alias | ARA3 | |
Cytomap | 1q25.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9Y6Y0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10625 | IVNS1ABP | LZE4T | Human | Esophagus | ESCC | 2.73e-07 | 5.15e-01 | 0.0811 |
10625 | IVNS1ABP | LZE5T | Human | Esophagus | ESCC | 4.37e-02 | -1.96e-01 | 0.0514 |
10625 | IVNS1ABP | LZE7T | Human | Esophagus | ESCC | 7.73e-13 | 1.76e+00 | 0.0667 |
10625 | IVNS1ABP | LZE8T | Human | Esophagus | ESCC | 3.95e-06 | 1.18e-01 | 0.067 |
10625 | IVNS1ABP | LZE24T | Human | Esophagus | ESCC | 3.45e-07 | 6.14e-01 | 0.0596 |
10625 | IVNS1ABP | P1T-E | Human | Esophagus | ESCC | 3.86e-07 | 7.02e-01 | 0.0875 |
10625 | IVNS1ABP | P2T-E | Human | Esophagus | ESCC | 4.82e-14 | 3.87e-01 | 0.1177 |
10625 | IVNS1ABP | P4T-E | Human | Esophagus | ESCC | 7.71e-07 | 3.51e-01 | 0.1323 |
10625 | IVNS1ABP | P5T-E | Human | Esophagus | ESCC | 1.30e-05 | 2.92e-01 | 0.1327 |
10625 | IVNS1ABP | P8T-E | Human | Esophagus | ESCC | 3.99e-09 | 2.47e-01 | 0.0889 |
10625 | IVNS1ABP | P9T-E | Human | Esophagus | ESCC | 6.83e-14 | 6.51e-01 | 0.1131 |
10625 | IVNS1ABP | P10T-E | Human | Esophagus | ESCC | 3.67e-19 | 5.01e-01 | 0.116 |
10625 | IVNS1ABP | P11T-E | Human | Esophagus | ESCC | 2.02e-13 | 2.22e+00 | 0.1426 |
10625 | IVNS1ABP | P12T-E | Human | Esophagus | ESCC | 1.92e-21 | 8.00e-01 | 0.1122 |
10625 | IVNS1ABP | P15T-E | Human | Esophagus | ESCC | 3.69e-32 | 1.08e+00 | 0.1149 |
10625 | IVNS1ABP | P16T-E | Human | Esophagus | ESCC | 2.61e-22 | 7.56e-01 | 0.1153 |
10625 | IVNS1ABP | P20T-E | Human | Esophagus | ESCC | 1.49e-14 | 6.74e-01 | 0.1124 |
10625 | IVNS1ABP | P21T-E | Human | Esophagus | ESCC | 6.73e-21 | 7.39e-01 | 0.1617 |
10625 | IVNS1ABP | P22T-E | Human | Esophagus | ESCC | 5.59e-10 | 6.44e-02 | 0.1236 |
10625 | IVNS1ABP | P23T-E | Human | Esophagus | ESCC | 2.92e-20 | 6.34e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0097193111 | Esophagus | ESCC | intrinsic apoptotic signaling pathway | 222/8552 | 288/18723 | 5.87e-28 | 2.02e-25 | 222 |
GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
GO:1903320111 | Esophagus | ESCC | regulation of protein modification by small protein conjugation or removal | 181/8552 | 242/18723 | 1.80e-20 | 2.60e-18 | 181 |
GO:2001242111 | Esophagus | ESCC | regulation of intrinsic apoptotic signaling pathway | 128/8552 | 164/18723 | 1.75e-17 | 1.50e-15 | 128 |
GO:0031396111 | Esophagus | ESCC | regulation of protein ubiquitination | 154/8552 | 210/18723 | 2.70e-16 | 2.04e-14 | 154 |
GO:2001234111 | Esophagus | ESCC | negative regulation of apoptotic signaling pathway | 161/8552 | 224/18723 | 1.24e-15 | 8.09e-14 | 161 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:2001243111 | Esophagus | ESCC | negative regulation of intrinsic apoptotic signaling pathway | 78/8552 | 98/18723 | 5.50e-12 | 2.10e-10 | 78 |
GO:00063833 | Esophagus | ESCC | transcription by RNA polymerase III | 41/8552 | 46/18723 | 7.69e-10 | 1.90e-08 | 41 |
GO:0031397111 | Esophagus | ESCC | negative regulation of protein ubiquitination | 63/8552 | 83/18723 | 1.87e-08 | 3.65e-07 | 63 |
GO:1903321111 | Esophagus | ESCC | negative regulation of protein modification by small protein conjugation or removal | 69/8552 | 95/18723 | 8.54e-08 | 1.44e-06 | 69 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:200123312 | Liver | Cirrhotic | regulation of apoptotic signaling pathway | 163/4634 | 356/18723 | 2.62e-18 | 4.43e-16 | 163 |
GO:009719312 | Liver | Cirrhotic | intrinsic apoptotic signaling pathway | 130/4634 | 288/18723 | 2.69e-14 | 2.45e-12 | 130 |
GO:20012427 | Liver | Cirrhotic | regulation of intrinsic apoptotic signaling pathway | 82/4634 | 164/18723 | 2.35e-12 | 1.71e-10 | 82 |
GO:20012347 | Liver | Cirrhotic | negative regulation of apoptotic signaling pathway | 102/4634 | 224/18723 | 8.40e-12 | 5.60e-10 | 102 |
GO:190332012 | Liver | Cirrhotic | regulation of protein modification by small protein conjugation or removal | 105/4634 | 242/18723 | 1.43e-10 | 7.43e-09 | 105 |
GO:003139612 | Liver | Cirrhotic | regulation of protein ubiquitination | 89/4634 | 210/18723 | 1.40e-08 | 5.30e-07 | 89 |
GO:20012437 | Liver | Cirrhotic | negative regulation of intrinsic apoptotic signaling pathway | 47/4634 | 98/18723 | 5.26e-07 | 1.17e-05 | 47 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IVNS1ABP | SNV | Missense_Mutation | c.1220G>A | p.Arg407Gln | p.R407Q | Q9Y6Y0 | protein_coding | tolerated(0.1) | probably_damaging(0.998) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
IVNS1ABP | SNV | Missense_Mutation | c.1096N>G | p.Met366Val | p.M366V | Q9Y6Y0 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |
IVNS1ABP | SNV | Missense_Mutation | c.380N>A | p.Ser127Tyr | p.S127Y | Q9Y6Y0 | protein_coding | deleterious(0.01) | possibly_damaging(0.635) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IVNS1ABP | SNV | Missense_Mutation | c.1865N>T | p.Thr622Met | p.T622M | Q9Y6Y0 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IVNS1ABP | SNV | Missense_Mutation | rs764078356 | c.1843N>A | p.Asp615Asn | p.D615N | Q9Y6Y0 | protein_coding | tolerated(0.48) | possibly_damaging(0.874) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
IVNS1ABP | SNV | Missense_Mutation | c.1043N>G | p.Glu348Gly | p.E348G | Q9Y6Y0 | protein_coding | tolerated(0.28) | benign(0.214) | TCGA-FP-8099-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IVNS1ABP | SNV | Missense_Mutation | novel | c.439N>C | p.Ser147Pro | p.S147P | Q9Y6Y0 | protein_coding | tolerated(0.31) | benign(0.044) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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