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Gene: IPO13 |
Gene summary for IPO13 |
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Gene information | Species | Human | Gene symbol | IPO13 | Gene ID | 9670 |
Gene name | importin 13 | |
Gene Alias | IMP13 | |
Cytomap | 1p34.1 | |
Gene Type | protein-coding | GO ID | GO:0006606 | UniProtAcc | O94829 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9670 | IPO13 | HCC1_Meng | Human | Liver | HCC | 5.58e-17 | 2.80e-02 | 0.0246 |
9670 | IPO13 | HCC2 | Human | Liver | HCC | 2.62e-08 | 2.11e+00 | 0.5341 |
9670 | IPO13 | S014 | Human | Liver | HCC | 8.28e-13 | 4.71e-01 | 0.2254 |
9670 | IPO13 | S015 | Human | Liver | HCC | 1.73e-12 | 4.61e-01 | 0.2375 |
9670 | IPO13 | S016 | Human | Liver | HCC | 2.40e-19 | 4.67e-01 | 0.2243 |
9670 | IPO13 | S027 | Human | Liver | HCC | 1.26e-08 | 5.78e-01 | 0.2446 |
9670 | IPO13 | S028 | Human | Liver | HCC | 1.03e-17 | 5.57e-01 | 0.2503 |
9670 | IPO13 | S029 | Human | Liver | HCC | 8.46e-18 | 5.71e-01 | 0.2581 |
9670 | IPO13 | C04 | Human | Oral cavity | OSCC | 2.92e-09 | 4.35e-01 | 0.2633 |
9670 | IPO13 | C21 | Human | Oral cavity | OSCC | 2.19e-09 | 4.14e-01 | 0.2678 |
9670 | IPO13 | C30 | Human | Oral cavity | OSCC | 1.08e-13 | 6.33e-01 | 0.3055 |
9670 | IPO13 | C38 | Human | Oral cavity | OSCC | 9.23e-03 | 3.22e-01 | 0.172 |
9670 | IPO13 | C43 | Human | Oral cavity | OSCC | 1.01e-08 | 1.26e-01 | 0.1704 |
9670 | IPO13 | C46 | Human | Oral cavity | OSCC | 9.55e-06 | 1.70e-01 | 0.1673 |
9670 | IPO13 | C51 | Human | Oral cavity | OSCC | 3.58e-06 | 4.00e-01 | 0.2674 |
9670 | IPO13 | C06 | Human | Oral cavity | OSCC | 1.79e-02 | 6.40e-01 | 0.2699 |
9670 | IPO13 | LN46 | Human | Oral cavity | OSCC | 4.92e-02 | 1.33e-01 | 0.1666 |
9670 | IPO13 | SYSMH1 | Human | Oral cavity | OSCC | 4.59e-05 | 1.50e-01 | 0.1127 |
9670 | IPO13 | SYSMH2 | Human | Oral cavity | OSCC | 4.39e-05 | 1.37e-01 | 0.2326 |
9670 | IPO13 | SYSMH3 | Human | Oral cavity | OSCC | 5.25e-17 | 3.42e-01 | 0.2442 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007259422 | Liver | HCC | establishment of protein localization to organelle | 299/7958 | 422/18723 | 1.06e-32 | 6.10e-30 | 299 |
GO:000691322 | Liver | HCC | nucleocytoplasmic transport | 208/7958 | 301/18723 | 5.51e-21 | 8.12e-19 | 208 |
GO:005116922 | Liver | HCC | nuclear transport | 208/7958 | 301/18723 | 5.51e-21 | 8.12e-19 | 208 |
GO:003450421 | Liver | HCC | protein localization to nucleus | 194/7958 | 290/18723 | 2.84e-17 | 2.85e-15 | 194 |
GO:001703811 | Liver | HCC | protein import | 140/7958 | 206/18723 | 1.12e-13 | 6.46e-12 | 140 |
GO:005117011 | Liver | HCC | import into nucleus | 102/7958 | 159/18723 | 2.78e-08 | 6.39e-07 | 102 |
GO:00066066 | Liver | HCC | protein import into nucleus | 99/7958 | 155/18723 | 6.12e-08 | 1.28e-06 | 99 |
GO:007259418 | Oral cavity | OSCC | establishment of protein localization to organelle | 284/7305 | 422/18723 | 1.50e-32 | 1.35e-29 | 284 |
GO:000691317 | Oral cavity | OSCC | nucleocytoplasmic transport | 204/7305 | 301/18723 | 2.65e-24 | 6.98e-22 | 204 |
GO:005116917 | Oral cavity | OSCC | nuclear transport | 204/7305 | 301/18723 | 2.65e-24 | 6.98e-22 | 204 |
GO:003450415 | Oral cavity | OSCC | protein localization to nucleus | 193/7305 | 290/18723 | 1.22e-21 | 2.35e-19 | 193 |
GO:001703815 | Oral cavity | OSCC | protein import | 136/7305 | 206/18723 | 3.15e-15 | 2.08e-13 | 136 |
GO:00511709 | Oral cavity | OSCC | import into nucleus | 100/7305 | 159/18723 | 8.67e-10 | 2.15e-08 | 100 |
GO:00066069 | Oral cavity | OSCC | protein import into nucleus | 97/7305 | 155/18723 | 2.27e-09 | 5.30e-08 | 97 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03013 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa030131 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa030136 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa0301311 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IPO13 | SNV | Missense_Mutation | rs752950730 | c.758N>T | p.Ser253Leu | p.S253L | O94829 | protein_coding | deleterious(0.01) | benign(0.129) | TCGA-CR-7373-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
IPO13 | SNV | Missense_Mutation | rs372139269 | c.2750N>A | p.Arg917His | p.R917H | O94829 | protein_coding | tolerated(0.26) | benign(0.01) | TCGA-CV-7236-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IPO13 | SNV | Missense_Mutation | novel | c.1189N>T | p.Leu397Phe | p.L397F | O94829 | protein_coding | deleterious(0) | possibly_damaging(0.764) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IPO13 | SNV | Missense_Mutation | novel | c.833N>A | p.Thr278Lys | p.T278K | O94829 | protein_coding | deleterious(0.01) | possibly_damaging(0.717) | TCGA-CV-A6K1-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
IPO13 | SNV | Missense_Mutation | novel | c.1781N>C | p.Leu594Pro | p.L594P | O94829 | protein_coding | deleterious(0.01) | possibly_damaging(0.898) | TCGA-KU-A66S-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
IPO13 | SNV | Missense_Mutation | c.592N>G | p.Cys198Gly | p.C198G | O94829 | protein_coding | tolerated(0.17) | benign(0.062) | TCGA-EJ-7317-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD | |
IPO13 | SNV | Missense_Mutation | c.2351N>A | p.Arg784Lys | p.R784K | O94829 | protein_coding | tolerated(0.27) | benign(0.012) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IPO13 | SNV | Missense_Mutation | c.2302T>A | p.Phe768Ile | p.F768I | O94829 | protein_coding | tolerated(0.48) | benign(0.017) | TCGA-BR-6802-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | CR | |
IPO13 | SNV | Missense_Mutation | c.382N>A | p.Ala128Thr | p.A128T | O94829 | protein_coding | deleterious(0.01) | possibly_damaging(0.872) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IPO13 | SNV | Missense_Mutation | rs775594295 | c.205N>A | p.Asp69Asn | p.D69N | O94829 | protein_coding | tolerated(0.27) | benign(0.056) | TCGA-F1-6177-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9670 | IPO13 | NA | MKC-1 | ENMD-981693 |
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