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Gene: INTS5 |
Gene summary for INTS5 |
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Gene information | Species | Human | Gene symbol | INTS5 | Gene ID | 80789 |
Gene name | integrator complex subunit 5 | |
Gene Alias | INT5 | |
Cytomap | 11q12.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6P9B9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80789 | INTS5 | LZE4T | Human | Esophagus | ESCC | 2.61e-02 | 5.39e-02 | 0.0811 |
80789 | INTS5 | LZE20T | Human | Esophagus | ESCC | 2.56e-02 | 8.51e-02 | 0.0662 |
80789 | INTS5 | LZE24T | Human | Esophagus | ESCC | 7.22e-09 | 2.78e-01 | 0.0596 |
80789 | INTS5 | P2T-E | Human | Esophagus | ESCC | 1.99e-10 | 1.60e-01 | 0.1177 |
80789 | INTS5 | P4T-E | Human | Esophagus | ESCC | 8.22e-13 | 2.40e-01 | 0.1323 |
80789 | INTS5 | P5T-E | Human | Esophagus | ESCC | 1.61e-03 | 2.08e-02 | 0.1327 |
80789 | INTS5 | P8T-E | Human | Esophagus | ESCC | 1.36e-10 | 1.68e-01 | 0.0889 |
80789 | INTS5 | P9T-E | Human | Esophagus | ESCC | 5.33e-07 | 1.10e-01 | 0.1131 |
80789 | INTS5 | P10T-E | Human | Esophagus | ESCC | 5.70e-08 | 4.71e-02 | 0.116 |
80789 | INTS5 | P11T-E | Human | Esophagus | ESCC | 1.64e-05 | 2.06e-01 | 0.1426 |
80789 | INTS5 | P12T-E | Human | Esophagus | ESCC | 1.93e-14 | 2.08e-01 | 0.1122 |
80789 | INTS5 | P15T-E | Human | Esophagus | ESCC | 4.04e-04 | 2.93e-02 | 0.1149 |
80789 | INTS5 | P16T-E | Human | Esophagus | ESCC | 3.63e-08 | 1.22e-01 | 0.1153 |
80789 | INTS5 | P17T-E | Human | Esophagus | ESCC | 1.25e-06 | 1.61e-01 | 0.1278 |
80789 | INTS5 | P20T-E | Human | Esophagus | ESCC | 1.93e-06 | 1.13e-01 | 0.1124 |
80789 | INTS5 | P21T-E | Human | Esophagus | ESCC | 1.11e-07 | 2.62e-01 | 0.1617 |
80789 | INTS5 | P22T-E | Human | Esophagus | ESCC | 1.83e-05 | 7.80e-02 | 0.1236 |
80789 | INTS5 | P23T-E | Human | Esophagus | ESCC | 7.44e-15 | 2.65e-01 | 0.108 |
80789 | INTS5 | P24T-E | Human | Esophagus | ESCC | 1.82e-09 | 1.72e-01 | 0.1287 |
80789 | INTS5 | P26T-E | Human | Esophagus | ESCC | 1.92e-08 | 1.26e-01 | 0.1276 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00311233 | Esophagus | ESCC | RNA 3'-end processing | 76/8552 | 116/18723 | 1.25e-05 | 1.15e-04 | 76 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
INTS5 | SNV | Missense_Mutation | novel | c.1768G>A | p.Glu590Lys | p.E590K | Q6P9B9 | protein_coding | tolerated(0.7) | benign(0.006) | TCGA-64-5781-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
INTS5 | SNV | Missense_Mutation | c.1523T>C | p.Val508Ala | p.V508A | Q6P9B9 | protein_coding | deleterious(0.01) | benign(0.142) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
INTS5 | SNV | Missense_Mutation | novel | c.1123N>T | p.His375Tyr | p.H375Y | Q6P9B9 | protein_coding | tolerated(0.14) | benign(0.33) | TCGA-73-4675-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | alimta | PD |
INTS5 | SNV | Missense_Mutation | c.2354A>T | p.His785Leu | p.H785L | Q6P9B9 | protein_coding | tolerated(0.32) | benign(0.017) | TCGA-MP-A4TK-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
INTS5 | SNV | Missense_Mutation | c.1734N>T | p.Leu578Phe | p.L578F | Q6P9B9 | protein_coding | tolerated(0.06) | probably_damaging(0.998) | TCGA-18-4083-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD | |
INTS5 | SNV | Missense_Mutation | novel | c.1000N>A | p.Leu334Ile | p.L334I | Q6P9B9 | protein_coding | tolerated(0.07) | benign(0.281) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
INTS5 | SNV | Missense_Mutation | novel | c.2190C>A | p.Asp730Glu | p.D730E | Q6P9B9 | protein_coding | tolerated(0.43) | benign(0.001) | TCGA-63-7023-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unspecific | Vinorelbine Tartrate | SD |
INTS5 | SNV | Missense_Mutation | c.2476N>A | p.Gly826Ser | p.G826S | Q6P9B9 | protein_coding | tolerated(0.35) | benign(0.06) | TCGA-66-2756-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
INTS5 | SNV | Missense_Mutation | novel | c.2902N>G | p.Arg968Gly | p.R968G | Q6P9B9 | protein_coding | deleterious(0.02) | benign(0.229) | TCGA-85-7698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR |
INTS5 | SNV | Missense_Mutation | novel | c.952N>T | p.His318Tyr | p.H318Y | Q6P9B9 | protein_coding | deleterious(0.01) | possibly_damaging(0.526) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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