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Gene: ICE1 |
Gene summary for ICE1 |
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Gene information | Species | Human | Gene symbol | ICE1 | Gene ID | 23379 |
Gene name | interactor of little elongation complex ELL subunit 1 | |
Gene Alias | KIAA0947 | |
Cytomap | 5p15.32 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9Y2F5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23379 | ICE1 | LZE2T | Human | Esophagus | ESCC | 4.42e-06 | 7.63e-01 | 0.082 |
23379 | ICE1 | LZE4T | Human | Esophagus | ESCC | 2.48e-09 | 8.95e-02 | 0.0811 |
23379 | ICE1 | LZE7T | Human | Esophagus | ESCC | 4.44e-03 | 6.52e-02 | 0.0667 |
23379 | ICE1 | LZE24T | Human | Esophagus | ESCC | 2.39e-08 | 2.05e-01 | 0.0596 |
23379 | ICE1 | P1T-E | Human | Esophagus | ESCC | 3.06e-15 | 5.90e-01 | 0.0875 |
23379 | ICE1 | P2T-E | Human | Esophagus | ESCC | 7.66e-36 | 6.50e-01 | 0.1177 |
23379 | ICE1 | P4T-E | Human | Esophagus | ESCC | 2.19e-30 | 7.40e-01 | 0.1323 |
23379 | ICE1 | P5T-E | Human | Esophagus | ESCC | 2.87e-27 | 5.24e-01 | 0.1327 |
23379 | ICE1 | P8T-E | Human | Esophagus | ESCC | 3.28e-25 | 4.42e-01 | 0.0889 |
23379 | ICE1 | P9T-E | Human | Esophagus | ESCC | 9.70e-21 | 3.20e-01 | 0.1131 |
23379 | ICE1 | P10T-E | Human | Esophagus | ESCC | 2.20e-31 | 6.47e-01 | 0.116 |
23379 | ICE1 | P11T-E | Human | Esophagus | ESCC | 5.52e-14 | 3.73e-01 | 0.1426 |
23379 | ICE1 | P12T-E | Human | Esophagus | ESCC | 3.43e-34 | 7.05e-01 | 0.1122 |
23379 | ICE1 | P15T-E | Human | Esophagus | ESCC | 1.21e-16 | 3.22e-01 | 0.1149 |
23379 | ICE1 | P16T-E | Human | Esophagus | ESCC | 7.31e-21 | 2.07e-01 | 0.1153 |
23379 | ICE1 | P17T-E | Human | Esophagus | ESCC | 9.88e-22 | 7.71e-01 | 0.1278 |
23379 | ICE1 | P19T-E | Human | Esophagus | ESCC | 1.24e-06 | 2.82e-01 | 0.1662 |
23379 | ICE1 | P20T-E | Human | Esophagus | ESCC | 8.38e-29 | 4.05e-01 | 0.1124 |
23379 | ICE1 | P21T-E | Human | Esophagus | ESCC | 2.75e-24 | 4.74e-01 | 0.1617 |
23379 | ICE1 | P22T-E | Human | Esophagus | ESCC | 2.53e-20 | 3.38e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0007051 | Colorectum | AD | spindle organization | 58/3918 | 184/18723 | 4.71e-04 | 5.20e-03 | 58 |
GO:1902850 | Colorectum | AD | microtubule cytoskeleton organization involved in mitosis | 48/3918 | 147/18723 | 5.87e-04 | 6.21e-03 | 48 |
GO:0090307 | Colorectum | AD | mitotic spindle assembly | 25/3918 | 65/18723 | 9.12e-04 | 8.71e-03 | 25 |
GO:0007052 | Colorectum | AD | mitotic spindle organization | 40/3918 | 120/18723 | 1.03e-03 | 9.61e-03 | 40 |
GO:0051225 | Colorectum | AD | spindle assembly | 37/3918 | 117/18723 | 4.32e-03 | 2.96e-02 | 37 |
GO:0140014 | Colorectum | AD | mitotic nuclear division | 78/3918 | 287/18723 | 6.48e-03 | 4.05e-02 | 78 |
GO:0046605 | Colorectum | AD | regulation of centrosome cycle | 18/3918 | 49/18723 | 7.93e-03 | 4.73e-02 | 18 |
GO:00516561 | Colorectum | SER | establishment of organelle localization | 100/2897 | 390/18723 | 1.11e-07 | 6.79e-06 | 100 |
GO:00466051 | Colorectum | SER | regulation of centrosome cycle | 17/2897 | 49/18723 | 7.17e-04 | 9.44e-03 | 17 |
GO:0010824 | Colorectum | SER | regulation of centrosome duplication | 15/2897 | 45/18723 | 2.29e-03 | 2.19e-02 | 15 |
GO:00516562 | Colorectum | MSS | establishment of organelle localization | 115/3467 | 390/18723 | 7.30e-08 | 3.67e-06 | 115 |
GO:00070511 | Colorectum | MSS | spindle organization | 53/3467 | 184/18723 | 4.23e-04 | 5.19e-03 | 53 |
GO:19028501 | Colorectum | MSS | microtubule cytoskeleton organization involved in mitosis | 44/3467 | 147/18723 | 5.17e-04 | 5.98e-03 | 44 |
GO:00070521 | Colorectum | MSS | mitotic spindle organization | 36/3467 | 120/18723 | 1.52e-03 | 1.39e-02 | 36 |
GO:00903071 | Colorectum | MSS | mitotic spindle assembly | 22/3467 | 65/18723 | 2.33e-03 | 1.90e-02 | 22 |
GO:00512251 | Colorectum | MSS | spindle assembly | 33/3467 | 117/18723 | 6.68e-03 | 4.38e-02 | 33 |
GO:01400141 | Colorectum | MSS | mitotic nuclear division | 70/3467 | 287/18723 | 7.48e-03 | 4.72e-02 | 70 |
GO:00516563 | Colorectum | FAP | establishment of organelle localization | 97/2622 | 390/18723 | 5.91e-09 | 9.48e-07 | 97 |
GO:00070512 | Colorectum | FAP | spindle organization | 41/2622 | 184/18723 | 1.50e-03 | 1.34e-02 | 41 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ICE1 | insertion | Frame_Shift_Ins | novel | c.124_125insA | p.Ile44AsnfsTer6 | p.I44Nfs*6 | Q9Y2F5 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ICE1 | deletion | Frame_Shift_Del | c.239delN | p.Ile82PhefsTer14 | p.I82Ffs*14 | Q9Y2F5 | protein_coding | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
ICE1 | insertion | Frame_Shift_Ins | novel | c.5891dupA | p.His1965AlafsTer55 | p.H1965Afs*55 | Q9Y2F5 | protein_coding | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
ICE1 | insertion | Frame_Shift_Ins | novel | c.3305_3306insG | p.Asp1105ArgfsTer4 | p.D1105Rfs*4 | Q9Y2F5 | protein_coding | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ICE1 | deletion | Frame_Shift_Del | c.3311delG | p.Gly1104GlufsTer6 | p.G1104Efs*6 | Q9Y2F5 | protein_coding | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
ICE1 | deletion | Frame_Shift_Del | c.972delN | p.Phe326LeufsTer82 | p.F326Lfs*82 | Q9Y2F5 | protein_coding | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
ICE1 | SNV | Missense_Mutation | novel | c.2695N>C | p.Ser899Pro | p.S899P | Q9Y2F5 | protein_coding | tolerated(1) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ICE1 | SNV | Missense_Mutation | novel | c.4343N>C | p.Ile1448Thr | p.I1448T | Q9Y2F5 | protein_coding | tolerated(0.62) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ICE1 | SNV | Missense_Mutation | novel | c.781N>C | p.Asn261His | p.N261H | Q9Y2F5 | protein_coding | tolerated(0.07) | benign(0.263) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ICE1 | SNV | Missense_Mutation | novel | c.2520N>C | p.Glu840Asp | p.E840D | Q9Y2F5 | protein_coding | tolerated(0.11) | benign(0.067) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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