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Gene: HMMR |
Gene summary for HMMR |
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Gene information | Species | Human | Gene symbol | HMMR | Gene ID | 3161 |
Gene name | hyaluronan mediated motility receptor | |
Gene Alias | CD168 | |
Cytomap | 5q34 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | O75330 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3161 | HMMR | LZE2T | Human | Esophagus | ESCC | 3.94e-07 | 6.95e-01 | 0.082 |
3161 | HMMR | P2T-E | Human | Esophagus | ESCC | 4.31e-06 | 3.43e-01 | 0.1177 |
3161 | HMMR | P4T-E | Human | Esophagus | ESCC | 6.14e-11 | 4.43e-01 | 0.1323 |
3161 | HMMR | P5T-E | Human | Esophagus | ESCC | 5.79e-16 | 5.52e-01 | 0.1327 |
3161 | HMMR | P10T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.75e-01 | 0.116 |
3161 | HMMR | P17T-E | Human | Esophagus | ESCC | 8.50e-05 | 4.29e-01 | 0.1278 |
3161 | HMMR | P19T-E | Human | Esophagus | ESCC | 6.53e-04 | 5.18e-01 | 0.1662 |
3161 | HMMR | P21T-E | Human | Esophagus | ESCC | 4.12e-11 | 4.33e-01 | 0.1617 |
3161 | HMMR | P22T-E | Human | Esophagus | ESCC | 8.84e-05 | 3.43e-01 | 0.1236 |
3161 | HMMR | P24T-E | Human | Esophagus | ESCC | 9.02e-11 | 4.22e-01 | 0.1287 |
3161 | HMMR | P28T-E | Human | Esophagus | ESCC | 2.02e-06 | 2.05e-01 | 0.1149 |
3161 | HMMR | P31T-E | Human | Esophagus | ESCC | 1.88e-04 | 2.18e-01 | 0.1251 |
3161 | HMMR | P32T-E | Human | Esophagus | ESCC | 1.35e-23 | 1.11e+00 | 0.1666 |
3161 | HMMR | P36T-E | Human | Esophagus | ESCC | 1.55e-04 | 3.72e-01 | 0.1187 |
3161 | HMMR | P37T-E | Human | Esophagus | ESCC | 3.34e-07 | 2.89e-01 | 0.1371 |
3161 | HMMR | P38T-E | Human | Esophagus | ESCC | 3.67e-05 | 3.85e-01 | 0.127 |
3161 | HMMR | P44T-E | Human | Esophagus | ESCC | 6.29e-05 | 3.04e-01 | 0.1096 |
3161 | HMMR | P52T-E | Human | Esophagus | ESCC | 9.20e-06 | 2.23e-01 | 0.1555 |
3161 | HMMR | P56T-E | Human | Esophagus | ESCC | 1.75e-02 | 8.30e-01 | 0.1613 |
3161 | HMMR | P62T-E | Human | Esophagus | ESCC | 2.60e-03 | 1.91e-01 | 0.1302 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HMMR | SNV | Missense_Mutation | c.881N>T | p.Cys294Phe | p.C294F | O75330 | protein_coding | deleterious(0.02) | benign(0.338) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
HMMR | SNV | Missense_Mutation | novel | c.1818G>T | p.Gln606His | p.Q606H | O75330 | protein_coding | deleterious(0.02) | possibly_damaging(0.66) | TCGA-44-7661-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HMMR | SNV | Missense_Mutation | rs200677786 | c.1819G>T | p.Ala607Ser | p.A607S | O75330 | protein_coding | deleterious(0) | benign(0.056) | TCGA-44-7661-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HMMR | SNV | Missense_Mutation | c.766N>T | p.Ala256Ser | p.A256S | O75330 | protein_coding | tolerated(0.07) | possibly_damaging(0.603) | TCGA-55-8205-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
HMMR | SNV | Missense_Mutation | c.438G>T | p.Arg146Ser | p.R146S | O75330 | protein_coding | deleterious(0) | possibly_damaging(0.53) | TCGA-91-6828-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HMMR | SNV | Missense_Mutation | c.1658G>C | p.Arg553Thr | p.R553T | O75330 | protein_coding | tolerated(0.08) | benign(0.005) | TCGA-18-3406-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HMMR | SNV | Missense_Mutation | c.1990G>T | p.Ala664Ser | p.A664S | O75330 | protein_coding | tolerated(0.19) | benign(0.359) | TCGA-60-2710-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | pemetrexed | SD | |
HMMR | SNV | Missense_Mutation | novel | c.1966N>A | p.Val656Ile | p.V656I | O75330 | protein_coding | tolerated(0.17) | benign(0.292) | TCGA-6A-AB49-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HMMR | SNV | Missense_Mutation | novel | c.322G>A | p.Asp108Asn | p.D108N | O75330 | protein_coding | tolerated(0.22) | benign(0.003) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HMMR | deletion | Frame_Shift_Del | rs761272507 | c.1993delN | p.Lys667AsnfsTer11 | p.K667Nfs*11 | O75330 | protein_coding | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3161 | HMMR | KINASE, CELL SURFACE, DRUGGABLE GENOME | epirubicin | EPIRUBICIN | ||
3161 | HMMR | KINASE, CELL SURFACE, DRUGGABLE GENOME | HYALURONAN | HYALURONAN | ||
3161 | HMMR | KINASE, CELL SURFACE, DRUGGABLE GENOME | fluorouracil | FLUOROURACIL | ||
3161 | HMMR | KINASE, CELL SURFACE, DRUGGABLE GENOME | cyclophosphamide | CYCLOPHOSPHAMIDE |
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