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Gene: GRHL1 |
Gene summary for GRHL1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | GRHL1 | Gene ID | 29841 |
Gene name | grainyhead like transcription factor 1 | |
Gene Alias | LBP32 | |
Cytomap | 2p25.1 | |
Gene Type | protein-coding | GO ID | GO:0002934 | UniProtAcc | Q9NZI5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29841 | GRHL1 | CCI_1 | Human | Cervix | CC | 9.24e-10 | 1.21e+00 | 0.528 |
29841 | GRHL1 | CCI_3 | Human | Cervix | CC | 3.82e-02 | 4.70e-01 | 0.516 |
29841 | GRHL1 | sample3 | Human | Cervix | CC | 1.74e-11 | 2.99e-01 | 0.1387 |
29841 | GRHL1 | H2 | Human | Cervix | HSIL_HPV | 2.11e-02 | 2.14e-01 | 0.0632 |
29841 | GRHL1 | L1 | Human | Cervix | CC | 2.52e-07 | 5.04e-01 | 0.0802 |
29841 | GRHL1 | T3 | Human | Cervix | CC | 1.97e-08 | 3.29e-01 | 0.1389 |
29841 | GRHL1 | LZE4T | Human | Esophagus | ESCC | 3.12e-03 | 2.13e-01 | 0.0811 |
29841 | GRHL1 | LZE22T | Human | Esophagus | ESCC | 2.04e-03 | 6.57e-01 | 0.068 |
29841 | GRHL1 | LZE24T | Human | Esophagus | ESCC | 1.02e-09 | 3.04e-01 | 0.0596 |
29841 | GRHL1 | P1T-E | Human | Esophagus | ESCC | 6.73e-10 | 6.32e-01 | 0.0875 |
29841 | GRHL1 | P2T-E | Human | Esophagus | ESCC | 4.84e-06 | 9.26e-02 | 0.1177 |
29841 | GRHL1 | P4T-E | Human | Esophagus | ESCC | 7.42e-17 | 5.37e-01 | 0.1323 |
29841 | GRHL1 | P5T-E | Human | Esophagus | ESCC | 7.84e-03 | 5.89e-02 | 0.1327 |
29841 | GRHL1 | P8T-E | Human | Esophagus | ESCC | 9.28e-14 | 2.39e-01 | 0.0889 |
29841 | GRHL1 | P12T-E | Human | Esophagus | ESCC | 5.27e-54 | 1.16e+00 | 0.1122 |
29841 | GRHL1 | P15T-E | Human | Esophagus | ESCC | 1.47e-18 | 4.24e-01 | 0.1149 |
29841 | GRHL1 | P16T-E | Human | Esophagus | ESCC | 1.35e-35 | 7.02e-01 | 0.1153 |
29841 | GRHL1 | P20T-E | Human | Esophagus | ESCC | 6.98e-09 | 2.24e-01 | 0.1124 |
29841 | GRHL1 | P21T-E | Human | Esophagus | ESCC | 4.46e-08 | 7.30e-02 | 0.1617 |
29841 | GRHL1 | P22T-E | Human | Esophagus | ESCC | 1.52e-05 | 1.07e-01 | 0.1236 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00085446 | Cervix | CC | epidermis development | 83/2311 | 324/18723 | 3.91e-11 | 8.54e-09 | 83 |
GO:00435884 | Cervix | CC | skin development | 71/2311 | 263/18723 | 8.04e-11 | 1.46e-08 | 71 |
GO:00302164 | Cervix | CC | keratinocyte differentiation | 42/2311 | 139/18723 | 1.74e-08 | 1.28e-06 | 42 |
GO:00452169 | Cervix | CC | cell-cell junction organization | 53/2311 | 200/18723 | 3.83e-08 | 2.53e-06 | 53 |
GO:00099137 | Cervix | CC | epidermal cell differentiation | 53/2311 | 202/18723 | 5.48e-08 | 3.25e-06 | 53 |
GO:005087810 | Cervix | CC | regulation of body fluid levels | 78/2311 | 379/18723 | 3.20e-06 | 8.77e-05 | 78 |
GO:00456822 | Cervix | CC | regulation of epidermis development | 22/2311 | 65/18723 | 5.56e-06 | 1.38e-04 | 22 |
GO:00456042 | Cervix | CC | regulation of epidermal cell differentiation | 20/2311 | 58/18723 | 1.07e-05 | 2.33e-04 | 20 |
GO:00029347 | Cervix | CC | desmosome organization | 7/2311 | 10/18723 | 3.69e-05 | 5.84e-04 | 7 |
GO:00456163 | Cervix | CC | regulation of keratinocyte differentiation | 14/2311 | 37/18723 | 6.97e-05 | 9.81e-04 | 14 |
GO:00308563 | Cervix | CC | regulation of epithelial cell differentiation | 36/2311 | 154/18723 | 1.02e-04 | 1.31e-03 | 36 |
GO:00614362 | Cervix | CC | establishment of skin barrier | 10/2311 | 25/18723 | 4.52e-04 | 4.49e-03 | 10 |
GO:00335612 | Cervix | CC | regulation of water loss via skin | 10/2311 | 27/18723 | 9.25e-04 | 7.84e-03 | 10 |
GO:000854413 | Cervix | HSIL_HPV | epidermis development | 38/737 | 324/18723 | 1.92e-09 | 3.23e-07 | 38 |
GO:003021611 | Cervix | HSIL_HPV | keratinocyte differentiation | 22/737 | 139/18723 | 2.53e-08 | 2.18e-06 | 22 |
GO:004358813 | Cervix | HSIL_HPV | skin development | 31/737 | 263/18723 | 5.32e-08 | 3.89e-06 | 31 |
GO:000991313 | Cervix | HSIL_HPV | epidermal cell differentiation | 26/737 | 202/18723 | 1.10e-07 | 7.15e-06 | 26 |
GO:005087814 | Cervix | HSIL_HPV | regulation of body fluid levels | 37/737 | 379/18723 | 3.81e-07 | 2.06e-05 | 37 |
GO:004521614 | Cervix | HSIL_HPV | cell-cell junction organization | 23/737 | 200/18723 | 4.21e-06 | 1.69e-04 | 23 |
GO:004561611 | Cervix | HSIL_HPV | regulation of keratinocyte differentiation | 8/737 | 37/18723 | 7.77e-05 | 1.77e-03 | 8 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRHL1 | SNV | Missense_Mutation | c.1552C>T | p.Pro518Ser | p.P518S | Q9NZI5 | protein_coding | tolerated(0.22) | benign(0.007) | TCGA-CN-6011-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD | |
GRHL1 | SNV | Missense_Mutation | novel | c.875N>A | p.Gly292Glu | p.G292E | Q9NZI5 | protein_coding | tolerated(0.4) | benign(0.191) | TCGA-CQ-6223-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GRHL1 | SNV | Missense_Mutation | c.1668N>C | p.Leu556Phe | p.L556F | Q9NZI5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CR-6481-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD | |
GRHL1 | SNV | Missense_Mutation | novel | c.1380N>G | p.Phe460Leu | p.F460L | Q9NZI5 | protein_coding | tolerated(0.36) | benign(0.39) | TCGA-CV-6961-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
GRHL1 | SNV | Missense_Mutation | novel | c.478N>C | p.Glu160Gln | p.E160Q | Q9NZI5 | protein_coding | tolerated(0.05) | probably_damaging(0.999) | TCGA-D6-A4ZB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
GRHL1 | insertion | Frame_Shift_Ins | novel | c.732dupT | p.Asp245Ter | p.D245* | Q9NZI5 | protein_coding | TCGA-QK-A6VB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
GRHL1 | SNV | Missense_Mutation | novel | c.1555N>G | p.Ser519Ala | p.S519A | Q9NZI5 | protein_coding | tolerated(0.47) | benign(0) | TCGA-V1-A9OA-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
GRHL1 | SNV | Missense_Mutation | c.1519N>A | p.Pro507Thr | p.P507T | Q9NZI5 | protein_coding | tolerated(0.4) | benign(0) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GRHL1 | SNV | Missense_Mutation | rs143356570 | c.1847C>T | p.Thr616Met | p.T616M | Q9NZI5 | protein_coding | tolerated(0.15) | benign(0.313) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GRHL1 | SNV | Missense_Mutation | rs548450490 | c.1280N>A | p.Arg427Gln | p.R427Q | Q9NZI5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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