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Gene: GMPS |
Gene summary for GMPS |
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Gene information | Species | Human | Gene symbol | GMPS | Gene ID | 8833 |
Gene name | guanine monophosphate synthase | |
Gene Alias | GATD7 | |
Cytomap | 3q25.31 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | A0A140VJK6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8833 | GMPS | GSM4909282 | Human | Breast | IDC | 4.61e-11 | 4.14e-01 | -0.0288 |
8833 | GMPS | GSM4909285 | Human | Breast | IDC | 4.27e-38 | 7.13e-01 | 0.21 |
8833 | GMPS | GSM4909287 | Human | Breast | IDC | 5.48e-06 | 3.17e-01 | 0.2057 |
8833 | GMPS | GSM4909293 | Human | Breast | IDC | 7.98e-06 | 2.20e-01 | 0.1581 |
8833 | GMPS | GSM4909297 | Human | Breast | IDC | 3.12e-03 | -5.68e-02 | 0.1517 |
8833 | GMPS | GSM4909311 | Human | Breast | IDC | 4.94e-08 | -1.49e-01 | 0.1534 |
8833 | GMPS | GSM4909319 | Human | Breast | IDC | 2.85e-12 | -1.17e-01 | 0.1563 |
8833 | GMPS | GSM4909321 | Human | Breast | IDC | 2.89e-04 | -7.85e-02 | 0.1559 |
8833 | GMPS | M2 | Human | Breast | IDC | 1.14e-02 | 2.49e-01 | 0.21 |
8833 | GMPS | NCCBC14 | Human | Breast | DCIS | 8.93e-07 | 2.83e-01 | 0.2021 |
8833 | GMPS | NCCBC5 | Human | Breast | DCIS | 1.58e-04 | 6.48e-03 | 0.2046 |
8833 | GMPS | P1 | Human | Breast | IDC | 2.70e-05 | 1.75e-02 | 0.1527 |
8833 | GMPS | P2 | Human | Breast | IDC | 1.01e-13 | 5.56e-01 | 0.21 |
8833 | GMPS | DCIS2 | Human | Breast | DCIS | 5.23e-47 | 2.22e-01 | 0.0085 |
8833 | GMPS | CCI_2 | Human | Cervix | CC | 6.32e-12 | 1.34e+00 | 0.5249 |
8833 | GMPS | CCI_3 | Human | Cervix | CC | 4.94e-08 | 6.61e-01 | 0.516 |
8833 | GMPS | Tumor | Human | Cervix | CC | 1.68e-06 | 2.64e-01 | 0.1241 |
8833 | GMPS | sample3 | Human | Cervix | CC | 7.86e-10 | 2.82e-01 | 0.1387 |
8833 | GMPS | T3 | Human | Cervix | CC | 2.88e-13 | 2.95e-01 | 0.1389 |
8833 | GMPS | LZE2T | Human | Esophagus | ESCC | 1.26e-07 | 1.07e+00 | 0.082 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000915214 | Breast | IDC | purine ribonucleotide biosynthetic process | 34/1434 | 169/18723 | 1.63e-07 | 8.92e-06 | 34 |
GO:004639013 | Breast | IDC | ribose phosphate biosynthetic process | 36/1434 | 190/18723 | 3.40e-07 | 1.73e-05 | 36 |
GO:000926013 | Breast | IDC | ribonucleotide biosynthetic process | 35/1434 | 182/18723 | 3.40e-07 | 1.73e-05 | 35 |
GO:000915014 | Breast | IDC | purine ribonucleotide metabolic process | 55/1434 | 368/18723 | 1.30e-06 | 5.72e-05 | 55 |
GO:001969314 | Breast | IDC | ribose phosphate metabolic process | 58/1434 | 396/18723 | 1.31e-06 | 5.73e-05 | 58 |
GO:000675313 | Breast | IDC | nucleoside phosphate metabolic process | 68/1434 | 497/18723 | 2.01e-06 | 8.23e-05 | 68 |
GO:000911713 | Breast | IDC | nucleotide metabolic process | 67/1434 | 489/18723 | 2.28e-06 | 9.05e-05 | 67 |
GO:000925914 | Breast | IDC | ribonucleotide metabolic process | 56/1434 | 385/18723 | 2.47e-06 | 9.63e-05 | 56 |
GO:000616413 | Breast | IDC | purine nucleotide biosynthetic process | 34/1434 | 191/18723 | 3.11e-06 | 1.15e-04 | 34 |
GO:190129313 | Breast | IDC | nucleoside phosphate biosynthetic process | 41/1434 | 256/18723 | 5.15e-06 | 1.73e-04 | 41 |
GO:000616314 | Breast | IDC | purine nucleotide metabolic process | 56/1434 | 396/18723 | 5.90e-06 | 1.90e-04 | 56 |
GO:007252213 | Breast | IDC | purine-containing compound biosynthetic process | 34/1434 | 200/18723 | 8.79e-06 | 2.50e-04 | 34 |
GO:000916513 | Breast | IDC | nucleotide biosynthetic process | 40/1434 | 254/18723 | 1.01e-05 | 2.81e-04 | 40 |
GO:007252114 | Breast | IDC | purine-containing compound metabolic process | 57/1434 | 416/18723 | 1.28e-05 | 3.31e-04 | 57 |
GO:000915223 | Breast | DCIS | purine ribonucleotide biosynthetic process | 34/1390 | 169/18723 | 7.77e-08 | 4.47e-06 | 34 |
GO:004639022 | Breast | DCIS | ribose phosphate biosynthetic process | 36/1390 | 190/18723 | 1.59e-07 | 8.19e-06 | 36 |
GO:000926022 | Breast | DCIS | ribonucleotide biosynthetic process | 35/1390 | 182/18723 | 1.62e-07 | 8.24e-06 | 35 |
GO:001969324 | Breast | DCIS | ribose phosphate metabolic process | 58/1390 | 396/18723 | 4.80e-07 | 2.11e-05 | 58 |
GO:000915024 | Breast | DCIS | purine ribonucleotide metabolic process | 55/1390 | 368/18723 | 4.92e-07 | 2.14e-05 | 55 |
GO:000925924 | Breast | DCIS | ribonucleotide metabolic process | 56/1390 | 385/18723 | 9.44e-07 | 3.79e-05 | 56 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa009832 | Liver | HCC | Drug metabolism - other enzymes | 54/4020 | 80/8465 | 2.25e-04 | 1.09e-03 | 6.08e-04 | 54 |
hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa009833 | Liver | HCC | Drug metabolism - other enzymes | 54/4020 | 80/8465 | 2.25e-04 | 1.09e-03 | 6.08e-04 | 54 |
hsa012324 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa0123211 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GMPS | SNV | Missense_Mutation | novel | c.1855C>T | p.His619Tyr | p.H619Y | P49915 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-CV-A468-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GMPS | SNV | Missense_Mutation | c.1766N>T | p.Arg589Leu | p.R589L | P49915 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-HD-7832-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GMPS | SNV | Missense_Mutation | c.905N>G | p.Ser302Cys | p.S302C | P49915 | protein_coding | tolerated(0.08) | benign(0.005) | TCGA-UF-A7JT-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
GMPS | SNV | Missense_Mutation | c.1644N>C | p.Arg548Ser | p.R548S | P49915 | protein_coding | tolerated(0.17) | benign(0.015) | TCGA-BR-8077-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
GMPS | SNV | Missense_Mutation | rs762639569 | c.782N>G | p.Asn261Ser | p.N261S | P49915 | protein_coding | tolerated(0.15) | benign(0) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
GMPS | SNV | Missense_Mutation | c.1766G>A | p.Arg589His | p.R589H | P49915 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-HU-A4G9-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GMPS | SNV | Missense_Mutation | novel | c.425N>A | p.Gly142Asp | p.G142D | P49915 | protein_coding | tolerated(0.06) | benign(0.35) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
GMPS | SNV | Missense_Mutation | novel | c.192A>G | p.Ile64Met | p.I64M | P49915 | protein_coding | tolerated(0.08) | benign(0.271) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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