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Gene: FASTKD1 |
Gene summary for FASTKD1 |
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Gene information | Species | Human | Gene symbol | FASTKD1 | Gene ID | 79675 |
Gene name | FAST kinase domains 1 | |
Gene Alias | FASTKD1 | |
Cytomap | 2q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000959 | UniProtAcc | Q53R41 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79675 | FASTKD1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.52e-02 | -3.35e-01 | 0.0155 |
79675 | FASTKD1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.62e-13 | 6.64e-01 | -0.1954 |
79675 | FASTKD1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.13e-03 | -2.60e-01 | 0.3005 |
79675 | FASTKD1 | A001-C-207 | Human | Colorectum | FAP | 5.25e-07 | -3.58e-01 | 0.1278 |
79675 | FASTKD1 | A015-C-203 | Human | Colorectum | FAP | 5.51e-25 | -4.03e-01 | -0.1294 |
79675 | FASTKD1 | A015-C-204 | Human | Colorectum | FAP | 2.10e-04 | -2.32e-01 | -0.0228 |
79675 | FASTKD1 | A014-C-040 | Human | Colorectum | FAP | 2.21e-04 | -3.34e-01 | -0.1184 |
79675 | FASTKD1 | A002-C-201 | Human | Colorectum | FAP | 7.81e-14 | -3.68e-01 | 0.0324 |
79675 | FASTKD1 | A002-C-203 | Human | Colorectum | FAP | 8.34e-09 | -2.66e-01 | 0.2786 |
79675 | FASTKD1 | A001-C-119 | Human | Colorectum | FAP | 1.06e-07 | -4.06e-01 | -0.1557 |
79675 | FASTKD1 | A001-C-108 | Human | Colorectum | FAP | 5.41e-17 | -2.93e-01 | -0.0272 |
79675 | FASTKD1 | A002-C-205 | Human | Colorectum | FAP | 2.78e-19 | -3.28e-01 | -0.1236 |
79675 | FASTKD1 | A001-C-104 | Human | Colorectum | FAP | 4.93e-08 | -2.94e-01 | 0.0184 |
79675 | FASTKD1 | A015-C-005 | Human | Colorectum | FAP | 8.27e-05 | -2.55e-01 | -0.0336 |
79675 | FASTKD1 | A015-C-006 | Human | Colorectum | FAP | 6.08e-14 | -2.83e-01 | -0.0994 |
79675 | FASTKD1 | A015-C-106 | Human | Colorectum | FAP | 1.03e-11 | -2.42e-01 | -0.0511 |
79675 | FASTKD1 | A002-C-114 | Human | Colorectum | FAP | 1.23e-17 | -4.00e-01 | -0.1561 |
79675 | FASTKD1 | A015-C-104 | Human | Colorectum | FAP | 5.18e-28 | -3.25e-01 | -0.1899 |
79675 | FASTKD1 | A001-C-014 | Human | Colorectum | FAP | 2.23e-14 | -3.41e-01 | 0.0135 |
79675 | FASTKD1 | A002-C-016 | Human | Colorectum | FAP | 1.14e-22 | -3.61e-01 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903311 | Colorectum | AD | regulation of mRNA metabolic process | 117/3918 | 288/18723 | 1.69e-14 | 4.23e-12 | 117 |
GO:0006401 | Colorectum | AD | RNA catabolic process | 102/3918 | 278/18723 | 8.64e-10 | 6.76e-08 | 102 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0006402 | Colorectum | AD | mRNA catabolic process | 87/3918 | 232/18723 | 4.40e-09 | 2.84e-07 | 87 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0061013 | Colorectum | AD | regulation of mRNA catabolic process | 64/3918 | 166/18723 | 1.44e-07 | 6.59e-06 | 64 |
GO:0043487 | Colorectum | AD | regulation of RNA stability | 63/3918 | 170/18723 | 9.17e-07 | 3.12e-05 | 63 |
GO:0043488 | Colorectum | AD | regulation of mRNA stability | 59/3918 | 158/18723 | 1.50e-06 | 4.66e-05 | 59 |
GO:19033112 | Colorectum | MSS | regulation of mRNA metabolic process | 115/3467 | 288/18723 | 1.23e-17 | 6.41e-15 | 115 |
GO:00064012 | Colorectum | MSS | RNA catabolic process | 102/3467 | 278/18723 | 5.07e-13 | 1.02e-10 | 102 |
GO:00064022 | Colorectum | MSS | mRNA catabolic process | 89/3467 | 232/18723 | 8.70e-13 | 1.60e-10 | 89 |
GO:00442702 | Colorectum | MSS | cellular nitrogen compound catabolic process | 141/3467 | 451/18723 | 2.95e-11 | 3.83e-09 | 141 |
GO:00467002 | Colorectum | MSS | heterocycle catabolic process | 139/3467 | 445/18723 | 4.37e-11 | 5.05e-09 | 139 |
GO:00346552 | Colorectum | MSS | nucleobase-containing compound catabolic process | 129/3467 | 407/18723 | 7.48e-11 | 8.18e-09 | 129 |
GO:00610132 | Colorectum | MSS | regulation of mRNA catabolic process | 66/3467 | 166/18723 | 1.25e-10 | 1.26e-08 | 66 |
GO:19013612 | Colorectum | MSS | organic cyclic compound catabolic process | 148/3467 | 495/18723 | 3.47e-10 | 3.18e-08 | 148 |
GO:00434872 | Colorectum | MSS | regulation of RNA stability | 66/3467 | 170/18723 | 4.14e-10 | 3.49e-08 | 66 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FASTKD1 | insertion | Frame_Shift_Ins | novel | c.1878_1879insT | p.Pro627SerfsTer10 | p.P627Sfs*10 | Q53R41 | protein_coding | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FASTKD1 | insertion | Frame_Shift_Ins | rs771228336 | c.10_11insA | p.Thr4AsnfsTer34 | p.T4Nfs*34 | Q53R41 | protein_coding | TCGA-DF-A2KY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | ||
FASTKD1 | deletion | Frame_Shift_Del | novel | c.263delA | p.Asn88MetfsTer17 | p.N88Mfs*17 | Q53R41 | protein_coding | TCGA-EY-A5W2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FASTKD1 | SNV | Missense_Mutation | rs540349050 | c.1421N>T | p.Ala474Val | p.A474V | Q53R41 | protein_coding | deleterious(0.03) | benign(0.058) | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FASTKD1 | SNV | Missense_Mutation | rs150915965 | c.142N>A | p.Asp48Asn | p.D48N | Q53R41 | protein_coding | tolerated(0.44) | benign(0.006) | TCGA-ED-A4XI-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FASTKD1 | SNV | Missense_Mutation | c.1393G>T | p.Asp465Tyr | p.D465Y | Q53R41 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-05-4432-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
FASTKD1 | SNV | Missense_Mutation | novel | c.1751N>T | p.Asn584Ile | p.N584I | Q53R41 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-50-5045-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
FASTKD1 | SNV | Missense_Mutation | c.1577N>T | p.His526Leu | p.H526L | Q53R41 | protein_coding | deleterious(0.01) | benign(0.035) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD | |
FASTKD1 | SNV | Missense_Mutation | c.239N>T | p.Lys80Met | p.K80M | Q53R41 | protein_coding | deleterious(0.02) | possibly_damaging(0.907) | TCGA-64-5779-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | PD | |
FASTKD1 | SNV | Missense_Mutation | c.2411N>G | p.His804Arg | p.H804R | Q53R41 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-39-5016-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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