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Gene: ERCC3 |
Gene summary for ERCC3 |
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Gene information | Species | Human | Gene symbol | ERCC3 | Gene ID | 2071 |
Gene name | ERCC excision repair 3, TFIIH core complex helicase subunit | |
Gene Alias | BTF2 | |
Cytomap | 2q14.3 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | P19447 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2071 | ERCC3 | LZE4T | Human | Esophagus | ESCC | 7.12e-12 | 2.72e-01 | 0.0811 |
2071 | ERCC3 | LZE7T | Human | Esophagus | ESCC | 4.91e-04 | 4.91e-01 | 0.0667 |
2071 | ERCC3 | LZE8T | Human | Esophagus | ESCC | 4.84e-08 | 1.81e-01 | 0.067 |
2071 | ERCC3 | LZE20T | Human | Esophagus | ESCC | 1.37e-04 | 1.88e-01 | 0.0662 |
2071 | ERCC3 | LZE24T | Human | Esophagus | ESCC | 7.02e-20 | 4.61e-01 | 0.0596 |
2071 | ERCC3 | LZE21T | Human | Esophagus | ESCC | 4.86e-05 | 2.26e-01 | 0.0655 |
2071 | ERCC3 | LZE6T | Human | Esophagus | ESCC | 1.22e-02 | 1.47e-01 | 0.0845 |
2071 | ERCC3 | P1T-E | Human | Esophagus | ESCC | 8.89e-08 | 3.42e-01 | 0.0875 |
2071 | ERCC3 | P2T-E | Human | Esophagus | ESCC | 2.11e-27 | 3.98e-01 | 0.1177 |
2071 | ERCC3 | P4T-E | Human | Esophagus | ESCC | 7.11e-21 | 5.85e-01 | 0.1323 |
2071 | ERCC3 | P5T-E | Human | Esophagus | ESCC | 1.56e-12 | 2.03e-01 | 0.1327 |
2071 | ERCC3 | P8T-E | Human | Esophagus | ESCC | 4.40e-23 | 4.14e-01 | 0.0889 |
2071 | ERCC3 | P9T-E | Human | Esophagus | ESCC | 2.40e-15 | 2.41e-01 | 0.1131 |
2071 | ERCC3 | P10T-E | Human | Esophagus | ESCC | 2.26e-26 | 4.28e-01 | 0.116 |
2071 | ERCC3 | P11T-E | Human | Esophagus | ESCC | 5.41e-12 | 5.35e-01 | 0.1426 |
2071 | ERCC3 | P12T-E | Human | Esophagus | ESCC | 2.43e-40 | 7.26e-01 | 0.1122 |
2071 | ERCC3 | P15T-E | Human | Esophagus | ESCC | 5.34e-21 | 4.53e-01 | 0.1149 |
2071 | ERCC3 | P16T-E | Human | Esophagus | ESCC | 1.06e-27 | 4.60e-01 | 0.1153 |
2071 | ERCC3 | P17T-E | Human | Esophagus | ESCC | 6.73e-11 | 3.14e-01 | 0.1278 |
2071 | ERCC3 | P19T-E | Human | Esophagus | ESCC | 3.58e-11 | 5.75e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:000941113 | Esophagus | ESCC | response to UV | 115/8552 | 149/18723 | 3.29e-15 | 1.93e-13 | 115 |
GO:000635414 | Esophagus | ESCC | DNA-templated transcription, elongation | 76/8552 | 91/18723 | 8.35e-14 | 4.11e-12 | 76 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
GO:0070482111 | Esophagus | ESCC | response to oxygen levels | 218/8552 | 347/18723 | 6.91e-11 | 2.17e-09 | 218 |
GO:190199013 | Esophagus | ESCC | regulation of mitotic cell cycle phase transition | 191/8552 | 299/18723 | 1.35e-10 | 3.94e-09 | 191 |
GO:0036293111 | Esophagus | ESCC | response to decreased oxygen levels | 201/8552 | 322/18723 | 8.37e-10 | 2.04e-08 | 201 |
GO:000636814 | Esophagus | ESCC | transcription elongation from RNA polymerase II promoter | 56/8552 | 69/18723 | 1.40e-09 | 3.30e-08 | 56 |
GO:0001666111 | Esophagus | ESCC | response to hypoxia | 192/8552 | 307/18723 | 1.59e-09 | 3.69e-08 | 192 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:000854410 | Esophagus | ESCC | epidermis development | 193/8552 | 324/18723 | 2.87e-07 | 4.19e-06 | 193 |
GO:00063673 | Esophagus | ESCC | transcription initiation from RNA polymerase II promoter | 56/8552 | 77/18723 | 1.30e-06 | 1.59e-05 | 56 |
GO:000635211 | Esophagus | ESCC | DNA-templated transcription, initiation | 86/8552 | 130/18723 | 1.88e-06 | 2.19e-05 | 86 |
GO:00063602 | Esophagus | ESCC | transcription by RNA polymerase I | 42/8552 | 55/18723 | 3.41e-06 | 3.78e-05 | 42 |
GO:003239214 | Esophagus | ESCC | DNA geometric change | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:003250813 | Esophagus | ESCC | DNA duplex unwinding | 58/8552 | 84/18723 | 1.23e-05 | 1.14e-04 | 58 |
GO:000991310 | Esophagus | ESCC | epidermal cell differentiation | 122/8552 | 202/18723 | 1.69e-05 | 1.51e-04 | 122 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0342022 | Esophagus | ESCC | Nucleotide excision repair | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa030222 | Esophagus | ESCC | Basal transcription factors | 35/4205 | 45/8465 | 1.01e-04 | 4.06e-04 | 2.08e-04 | 35 |
hsa0342032 | Esophagus | ESCC | Nucleotide excision repair | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0302211 | Esophagus | ESCC | Basal transcription factors | 35/4205 | 45/8465 | 1.01e-04 | 4.06e-04 | 2.08e-04 | 35 |
hsa034202 | Liver | HCC | Nucleotide excision repair | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa034203 | Liver | HCC | Nucleotide excision repair | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa034204 | Oral cavity | OSCC | Nucleotide excision repair | 49/3704 | 63/8465 | 3.48e-08 | 2.91e-07 | 1.48e-07 | 49 |
hsa03022 | Oral cavity | OSCC | Basal transcription factors | 28/3704 | 45/8465 | 9.53e-03 | 2.11e-02 | 1.08e-02 | 28 |
hsa0342011 | Oral cavity | OSCC | Nucleotide excision repair | 49/3704 | 63/8465 | 3.48e-08 | 2.91e-07 | 1.48e-07 | 49 |
hsa030221 | Oral cavity | OSCC | Basal transcription factors | 28/3704 | 45/8465 | 9.53e-03 | 2.11e-02 | 1.08e-02 | 28 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ERCC3 | SNV | Missense_Mutation | novel | c.763N>G | p.Met255Val | p.M255V | P19447 | protein_coding | tolerated(0.72) | benign(0.001) | TCGA-CN-5367-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ERCC3 | SNV | Missense_Mutation | novel | c.2324C>A | p.Pro775Gln | p.P775Q | P19447 | protein_coding | deleterious(0.04) | possibly_damaging(0.764) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
ERCC3 | SNV | Missense_Mutation | rs772991846 | c.1317N>G | p.Ile439Met | p.I439M | P19447 | protein_coding | deleterious(0.03) | possibly_damaging(0.904) | TCGA-CV-7433-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ERCC3 | SNV | Missense_Mutation | novel | c.1738N>G | p.Ile580Val | p.I580V | P19447 | protein_coding | deleterious(0) | probably_damaging(0.913) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ERCC3 | SNV | Missense_Mutation | c.446C>T | p.Pro149Leu | p.P149L | P19447 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EJ-5509-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
ERCC3 | SNV | Missense_Mutation | c.1066A>G | p.Thr356Ala | p.T356A | P19447 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ERCC3 | SNV | Missense_Mutation | c.145N>C | p.Ser49Pro | p.S49P | P19447 | protein_coding | tolerated(0.06) | benign(0) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
ERCC3 | SNV | Missense_Mutation | rs189511674 | c.2291N>T | p.Ser764Leu | p.S764L | P19447 | protein_coding | deleterious(0.03) | benign(0.023) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ERCC3 | SNV | Missense_Mutation | c.1751N>T | p.Thr584Met | p.T584M | P19447 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD | |
ERCC3 | SNV | Missense_Mutation | c.1237C>A | p.Leu413Met | p.L413M | P19447 | protein_coding | deleterious(0.03) | possibly_damaging(0.457) | TCGA-HU-A4GP-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | didox | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2071 | ERCC3 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DNA REPAIR, ENZYME | Platinum compounds | 25069034 |
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