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Gene: EML3 |
Gene summary for EML3 |
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Gene information | Species | Human | Gene symbol | EML3 | Gene ID | 256364 |
Gene name | EMAP like 3 | |
Gene Alias | ELP95 | |
Cytomap | 11q12.3 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q32P44 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
256364 | EML3 | LZE2T | Human | Esophagus | ESCC | 2.53e-05 | 4.06e-01 | 0.082 |
256364 | EML3 | LZE4T | Human | Esophagus | ESCC | 8.02e-04 | 8.18e-02 | 0.0811 |
256364 | EML3 | LZE20T | Human | Esophagus | ESCC | 2.76e-04 | 1.27e-01 | 0.0662 |
256364 | EML3 | LZE24T | Human | Esophagus | ESCC | 7.03e-12 | 1.59e-01 | 0.0596 |
256364 | EML3 | P1T-E | Human | Esophagus | ESCC | 2.21e-06 | 2.36e-01 | 0.0875 |
256364 | EML3 | P2T-E | Human | Esophagus | ESCC | 8.02e-21 | 2.32e-01 | 0.1177 |
256364 | EML3 | P4T-E | Human | Esophagus | ESCC | 6.74e-09 | 2.92e-01 | 0.1323 |
256364 | EML3 | P5T-E | Human | Esophagus | ESCC | 7.47e-06 | 7.02e-02 | 0.1327 |
256364 | EML3 | P8T-E | Human | Esophagus | ESCC | 2.47e-26 | 4.38e-01 | 0.0889 |
256364 | EML3 | P9T-E | Human | Esophagus | ESCC | 1.70e-13 | 2.12e-01 | 0.1131 |
256364 | EML3 | P10T-E | Human | Esophagus | ESCC | 6.66e-20 | 1.01e-01 | 0.116 |
256364 | EML3 | P11T-E | Human | Esophagus | ESCC | 1.58e-11 | 3.55e-01 | 0.1426 |
256364 | EML3 | P12T-E | Human | Esophagus | ESCC | 9.46e-15 | 1.80e-01 | 0.1122 |
256364 | EML3 | P15T-E | Human | Esophagus | ESCC | 5.43e-06 | 7.47e-02 | 0.1149 |
256364 | EML3 | P16T-E | Human | Esophagus | ESCC | 1.22e-05 | 1.05e-01 | 0.1153 |
256364 | EML3 | P17T-E | Human | Esophagus | ESCC | 1.91e-04 | 2.84e-01 | 0.1278 |
256364 | EML3 | P19T-E | Human | Esophagus | ESCC | 3.29e-06 | 3.45e-01 | 0.1662 |
256364 | EML3 | P20T-E | Human | Esophagus | ESCC | 2.63e-16 | 3.25e-01 | 0.1124 |
256364 | EML3 | P21T-E | Human | Esophagus | ESCC | 2.85e-20 | 4.93e-01 | 0.1617 |
256364 | EML3 | P22T-E | Human | Esophagus | ESCC | 4.08e-02 | 2.52e-02 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:190285015 | Esophagus | ESCC | microtubule cytoskeleton organization involved in mitosis | 116/8552 | 147/18723 | 1.25e-16 | 9.91e-15 | 116 |
GO:000705214 | Esophagus | ESCC | mitotic spindle organization | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
GO:000705114 | Esophagus | ESCC | spindle organization | 134/8552 | 184/18723 | 5.70e-14 | 2.87e-12 | 134 |
GO:005131011 | Esophagus | ESCC | metaphase plate congression | 58/8552 | 65/18723 | 1.81e-13 | 8.63e-12 | 58 |
GO:000708011 | Esophagus | ESCC | mitotic metaphase plate congression | 47/8552 | 50/18723 | 3.15e-13 | 1.47e-11 | 47 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
GO:005130311 | Esophagus | ESCC | establishment of chromosome localization | 67/8552 | 80/18723 | 1.92e-12 | 8.09e-11 | 67 |
GO:005000011 | Esophagus | ESCC | chromosome localization | 68/8552 | 82/18723 | 3.37e-12 | 1.32e-10 | 68 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:00512256 | Esophagus | ESCC | spindle assembly | 85/8552 | 117/18723 | 2.72e-09 | 5.98e-08 | 85 |
GO:009030715 | Esophagus | ESCC | mitotic spindle assembly | 52/8552 | 65/18723 | 1.41e-08 | 2.77e-07 | 52 |
GO:00705078 | Esophagus | ESCC | regulation of microtubule cytoskeleton organization | 99/8552 | 148/18723 | 1.43e-07 | 2.29e-06 | 99 |
GO:190211514 | Esophagus | ESCC | regulation of organelle assembly | 116/8552 | 186/18723 | 3.15e-06 | 3.53e-05 | 116 |
GO:009022413 | Esophagus | ESCC | regulation of spindle organization | 32/8552 | 39/18723 | 3.27e-06 | 3.65e-05 | 32 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EML3 | SNV | Missense_Mutation | rs542275752 | c.689N>T | p.Pro230Leu | p.P230L | Q32P44 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F7-A50J-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
EML3 | SNV | Missense_Mutation | novel | c.1420N>G | p.Leu474Val | p.L474V | Q32P44 | protein_coding | tolerated(0.22) | possibly_damaging(0.664) | TCGA-HD-8635-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
EML3 | SNV | Missense_Mutation | c.346C>T | p.Pro116Ser | p.P116S | Q32P44 | protein_coding | tolerated(0.06) | benign(0.439) | TCGA-CH-5791-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | PD | |
EML3 | SNV | Missense_Mutation | novel | c.1322C>T | p.Pro441Leu | p.P441L | Q32P44 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-V1-A8ML-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
EML3 | SNV | Missense_Mutation | c.785N>A | p.Arg262His | p.R262H | Q32P44 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EML3 | SNV | Missense_Mutation | c.1013N>C | p.Val338Ala | p.V338A | Q32P44 | protein_coding | tolerated(0.21) | possibly_damaging(0.5) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EML3 | SNV | Missense_Mutation | rs374119034 | c.700N>T | p.Arg234Cys | p.R234C | Q32P44 | protein_coding | deleterious(0.04) | probably_damaging(0.94) | TCGA-CD-5801-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
EML3 | SNV | Missense_Mutation | novel | c.1037N>G | p.Thr346Arg | p.T346R | Q32P44 | protein_coding | deleterious(0) | possibly_damaging(0.702) | TCGA-D7-A6EZ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
EML3 | SNV | Missense_Mutation | c.614G>T | p.Arg205Leu | p.R205L | Q32P44 | protein_coding | deleterious(0) | benign(0.203) | TCGA-HU-A4G9-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EML3 | SNV | Missense_Mutation | c.404N>A | p.Gly135Asp | p.G135D | Q32P44 | protein_coding | deleterious(0.05) | probably_damaging(0.982) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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