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Gene: DLG3 |
Gene summary for DLG3 |
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Gene information | Species | Human | Gene symbol | DLG3 | Gene ID | 1741 |
Gene name | discs large MAGUK scaffold protein 3 | |
Gene Alias | MRX | |
Cytomap | Xq13.1 | |
Gene Type | protein-coding | GO ID | GO:0001736 | UniProtAcc | Q92796 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1741 | DLG3 | male-WTA | Human | Thyroid | PTC | 1.33e-17 | 1.83e-01 | 0.1037 |
1741 | DLG3 | PTC01 | Human | Thyroid | PTC | 9.36e-04 | 8.67e-02 | 0.1899 |
1741 | DLG3 | PTC04 | Human | Thyroid | PTC | 2.07e-10 | 2.62e-01 | 0.1927 |
1741 | DLG3 | PTC05 | Human | Thyroid | PTC | 6.16e-18 | 3.44e-01 | 0.2065 |
1741 | DLG3 | PTC06 | Human | Thyroid | PTC | 1.62e-17 | 5.02e-01 | 0.2057 |
1741 | DLG3 | PTC07 | Human | Thyroid | PTC | 6.28e-23 | 4.05e-01 | 0.2044 |
1741 | DLG3 | ATC09 | Human | Thyroid | ATC | 1.14e-05 | 1.30e-01 | 0.2871 |
1741 | DLG3 | ATC13 | Human | Thyroid | ATC | 2.57e-06 | 9.64e-02 | 0.34 |
1741 | DLG3 | ATC1 | Human | Thyroid | ATC | 2.31e-06 | 1.61e-01 | 0.2878 |
1741 | DLG3 | ATC4 | Human | Thyroid | ATC | 4.58e-02 | 5.08e-03 | 0.34 |
1741 | DLG3 | ATC5 | Human | Thyroid | ATC | 7.02e-05 | 1.20e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007163111 | Thyroid | PTC | establishment or maintenance of cell polarity | 115/5968 | 218/18723 | 1.15e-10 | 3.90e-09 | 115 |
GO:0045860111 | Thyroid | PTC | positive regulation of protein kinase activity | 176/5968 | 386/18723 | 8.89e-09 | 2.17e-07 | 176 |
GO:00315037 | Thyroid | PTC | protein-containing complex localization | 107/5968 | 220/18723 | 1.47e-07 | 2.82e-06 | 107 |
GO:0033674111 | Thyroid | PTC | positive regulation of kinase activity | 201/5968 | 467/18723 | 1.95e-07 | 3.54e-06 | 201 |
GO:00991738 | Thyroid | PTC | postsynapse organization | 77/5968 | 168/18723 | 1.01e-04 | 8.25e-04 | 77 |
GO:00610974 | Thyroid | PTC | regulation of protein tyrosine kinase activity | 45/5968 | 90/18723 | 2.57e-04 | 1.84e-03 | 45 |
GO:004519710 | Thyroid | PTC | establishment or maintenance of epithelial cell apical/basal polarity | 24/5968 | 44/18723 | 1.52e-03 | 8.49e-03 | 24 |
GO:003508810 | Thyroid | PTC | establishment or maintenance of apical/basal cell polarity | 26/5968 | 49/18723 | 1.68e-03 | 9.20e-03 | 26 |
GO:006124510 | Thyroid | PTC | establishment or maintenance of bipolar cell polarity | 26/5968 | 49/18723 | 1.68e-03 | 9.20e-03 | 26 |
GO:00508089 | Thyroid | PTC | synapse organization | 161/5968 | 426/18723 | 5.11e-03 | 2.36e-02 | 161 |
GO:00182126 | Thyroid | PTC | peptidyl-tyrosine modification | 142/5968 | 378/18723 | 1.02e-02 | 4.14e-02 | 142 |
GO:00017389 | Thyroid | PTC | morphogenesis of a polarized epithelium | 41/5968 | 94/18723 | 1.10e-02 | 4.38e-02 | 41 |
GO:000716329 | Thyroid | ATC | establishment or maintenance of cell polarity | 122/6293 | 218/18723 | 8.46e-12 | 3.16e-10 | 122 |
GO:004586026 | Thyroid | ATC | positive regulation of protein kinase activity | 185/6293 | 386/18723 | 3.00e-09 | 7.02e-08 | 185 |
GO:003367427 | Thyroid | ATC | positive regulation of kinase activity | 212/6293 | 467/18723 | 5.89e-08 | 1.05e-06 | 212 |
GO:003150316 | Thyroid | ATC | protein-containing complex localization | 108/6293 | 220/18723 | 1.33e-06 | 1.69e-05 | 108 |
GO:009917314 | Thyroid | ATC | postsynapse organization | 78/6293 | 168/18723 | 3.66e-04 | 2.26e-03 | 78 |
GO:006109712 | Thyroid | ATC | regulation of protein tyrosine kinase activity | 45/6293 | 90/18723 | 9.39e-04 | 5.04e-03 | 45 |
GO:001821211 | Thyroid | ATC | peptidyl-tyrosine modification | 156/6293 | 378/18723 | 1.01e-03 | 5.36e-03 | 156 |
GO:003508815 | Thyroid | ATC | establishment or maintenance of apical/basal cell polarity | 27/6293 | 49/18723 | 1.58e-03 | 7.99e-03 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DLG3 | SNV | Missense_Mutation | c.623N>A | p.Pro208His | p.P208H | Q92796 | protein_coding | tolerated(0.09) | probably_damaging(0.986) | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DLG3 | SNV | Missense_Mutation | novel | c.643C>T | p.Arg215Trp | p.R215W | Q92796 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
DLG3 | SNV | Missense_Mutation | c.605N>T | p.Ala202Val | p.A202V | Q92796 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | |
DLG3 | SNV | Missense_Mutation | c.941N>A | p.Ser314Asn | p.S314N | Q92796 | protein_coding | tolerated(0.35) | benign(0.012) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
DLG3 | SNV | Missense_Mutation | c.473N>A | p.Pro158His | p.P158H | Q92796 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD | |
DLG3 | insertion | Frame_Shift_Ins | novel | c.1086_1087insC | p.Thr365HisfsTer13 | p.T365Hfs*13 | Q92796 | protein_coding | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
DLG3 | insertion | Frame_Shift_Ins | novel | c.1515_1516insGTCA | p.Arg507SerfsTer6 | p.R507Sfs*6 | Q92796 | protein_coding | TCGA-CG-4477-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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