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Gene: DISP2 |
Gene summary for DISP2 |
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Gene information | Species | Human | Gene symbol | DISP2 | Gene ID | 85455 |
Gene name | dispatched RND transporter family member 2 | |
Gene Alias | C15orf36 | |
Cytomap | 15q15.1 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A7MBM2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85455 | DISP2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.37e-11 | 4.01e-01 | -0.1808 |
85455 | DISP2 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.70e-02 | 1.44e-01 | -0.1088 |
85455 | DISP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.76e-02 | 1.01e-01 | -0.1954 |
85455 | DISP2 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.40e-05 | 3.50e-01 | -0.1464 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DISP2 | insertion | Frame_Shift_Ins | novel | c.2607_2608insT | p.Leu872ProfsTer24 | p.L872Pfs*24 | A7MBM2 | protein_coding | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
DISP2 | SNV | Missense_Mutation | c.2663N>T | p.Gln888Leu | p.Q888L | A7MBM2 | protein_coding | tolerated(0.72) | benign(0) | TCGA-CC-A3MC-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
DISP2 | SNV | Missense_Mutation | c.2545A>T | p.Ser849Cys | p.S849C | A7MBM2 | protein_coding | tolerated(0.08) | benign(0.009) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
DISP2 | SNV | Missense_Mutation | novel | c.2446N>C | p.Cys816Arg | p.C816R | A7MBM2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-ZS-A9CD-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DISP2 | SNV | Missense_Mutation | c.1549C>A | p.Leu517Met | p.L517M | A7MBM2 | protein_coding | tolerated(0.71) | possibly_damaging(0.543) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DISP2 | SNV | Missense_Mutation | novel | c.1435N>A | p.Glu479Lys | p.E479K | A7MBM2 | protein_coding | tolerated(0.83) | benign(0) | TCGA-05-4397-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DISP2 | SNV | Missense_Mutation | rs775657161 | c.775N>A | p.Ala259Thr | p.A259T | A7MBM2 | protein_coding | tolerated(0.56) | benign(0) | TCGA-78-7159-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DISP2 | SNV | Missense_Mutation | c.2831N>A | p.Arg944His | p.R944H | A7MBM2 | protein_coding | tolerated(0.2) | benign(0.401) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD | |
DISP2 | SNV | Missense_Mutation | rs866801308 | c.841N>A | p.Pro281Thr | p.P281T | A7MBM2 | protein_coding | tolerated(0.25) | benign(0.124) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
DISP2 | SNV | Missense_Mutation | c.1523N>T | p.Arg508Leu | p.R508L | A7MBM2 | protein_coding | deleterious(0.01) | possibly_damaging(0.879) | TCGA-33-AASI-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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