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Gene: CXorf23 |
Gene summary for CXORF23 |
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Gene information | Species | Human | Gene symbol | CXorf23 | Gene ID | 256643 |
Gene name | BCLAF1 and THRAP3 family member 3 | |
Gene Alias | CXorf23 | |
Cytomap | Xp22.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A2AJT9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
256643 | CXorf23 | HCC1_Meng | Human | Liver | HCC | 9.64e-18 | -1.42e-03 | 0.0246 |
256643 | CXorf23 | HCC2_Meng | Human | Liver | HCC | 2.31e-20 | 1.44e-01 | 0.0107 |
256643 | CXorf23 | HCC1 | Human | Liver | HCC | 1.46e-03 | 1.62e+00 | 0.5336 |
256643 | CXorf23 | HCC2 | Human | Liver | HCC | 5.13e-21 | 3.24e+00 | 0.5341 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CXorf23 | SNV | Missense_Mutation | novel | c.404A>G | p.Gln135Arg | p.Q135R | A2AJT9 | protein_coding | tolerated(0.06) | possibly_damaging(0.89) | TCGA-VQ-A94U-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CXorf23 | insertion | Frame_Shift_Ins | novel | c.1804_1805insATTA | p.Thr602AsnfsTer7 | p.T602Nfs*7 | A2AJT9 | protein_coding | TCGA-BR-8365-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
CXorf23 | insertion | Nonsense_Mutation | novel | c.1775_1776insATACTAGT | p.Asn592LysfsTer3 | p.N592Kfs*3 | A2AJT9 | protein_coding | TCGA-FP-8099-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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