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Gene: CPT1A |
Gene summary for CPT1A |
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Gene information | Species | Human | Gene symbol | CPT1A | Gene ID | 1374 |
Gene name | carnitine palmitoyltransferase 1A | |
Gene Alias | CPT1 | |
Cytomap | 11q13.3 | |
Gene Type | protein-coding | GO ID | GO:0001676 | UniProtAcc | P50416 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1374 | CPT1A | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.48e-05 | -2.95e-01 | 0.0155 |
1374 | CPT1A | HTA11_347_2000001011 | Human | Colorectum | AD | 7.05e-37 | 1.23e+00 | -0.1954 |
1374 | CPT1A | HTA11_83_2000001011 | Human | Colorectum | SER | 6.79e-04 | 5.63e-01 | -0.1526 |
1374 | CPT1A | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.29e-03 | 6.30e-01 | -0.2061 |
1374 | CPT1A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.27e-04 | -2.96e-01 | 0.294 |
1374 | CPT1A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.25e-15 | -4.29e-01 | 0.3005 |
1374 | CPT1A | F007 | Human | Colorectum | FAP | 1.90e-08 | -5.04e-01 | 0.1176 |
1374 | CPT1A | A002-C-010 | Human | Colorectum | FAP | 2.21e-15 | -4.96e-01 | 0.242 |
1374 | CPT1A | A001-C-207 | Human | Colorectum | FAP | 2.59e-14 | -6.02e-01 | 0.1278 |
1374 | CPT1A | A015-C-203 | Human | Colorectum | FAP | 9.80e-36 | -5.12e-01 | -0.1294 |
1374 | CPT1A | A015-C-204 | Human | Colorectum | FAP | 3.17e-07 | -2.72e-01 | -0.0228 |
1374 | CPT1A | A014-C-040 | Human | Colorectum | FAP | 1.84e-08 | -5.86e-01 | -0.1184 |
1374 | CPT1A | A002-C-201 | Human | Colorectum | FAP | 3.61e-20 | -5.05e-01 | 0.0324 |
1374 | CPT1A | A002-C-203 | Human | Colorectum | FAP | 3.83e-15 | -4.45e-01 | 0.2786 |
1374 | CPT1A | A001-C-119 | Human | Colorectum | FAP | 3.77e-07 | -4.66e-01 | -0.1557 |
1374 | CPT1A | A001-C-108 | Human | Colorectum | FAP | 2.66e-24 | -5.04e-01 | -0.0272 |
1374 | CPT1A | A002-C-021 | Human | Colorectum | FAP | 6.73e-05 | -2.87e-01 | 0.1171 |
1374 | CPT1A | A002-C-205 | Human | Colorectum | FAP | 7.21e-30 | -5.82e-01 | -0.1236 |
1374 | CPT1A | A001-C-104 | Human | Colorectum | FAP | 1.72e-08 | -2.77e-01 | 0.0184 |
1374 | CPT1A | A015-C-005 | Human | Colorectum | FAP | 8.57e-12 | -4.51e-01 | -0.0336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:1990542 | Colorectum | AD | mitochondrial transmembrane transport | 47/3918 | 102/18723 | 1.09e-08 | 6.52e-07 | 47 |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0006635 | Colorectum | AD | fatty acid beta-oxidation | 33/3918 | 74/18723 | 3.98e-06 | 1.09e-04 | 33 |
GO:0009062 | Colorectum | AD | fatty acid catabolic process | 41/3918 | 100/18723 | 4.02e-06 | 1.09e-04 | 41 |
GO:0061008 | Colorectum | AD | hepaticobiliary system development | 55/3918 | 150/18723 | 6.34e-06 | 1.59e-04 | 55 |
GO:0001889 | Colorectum | AD | liver development | 54/3918 | 147/18723 | 7.20e-06 | 1.77e-04 | 54 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:0019318 | Colorectum | AD | hexose metabolic process | 77/3918 | 237/18723 | 1.96e-05 | 4.01e-04 | 77 |
GO:0019395 | Colorectum | AD | fatty acid oxidation | 40/3918 | 103/18723 | 2.43e-05 | 4.69e-04 | 40 |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
GO:0097421 | Colorectum | AD | liver regeneration | 18/3918 | 35/18723 | 6.33e-05 | 1.05e-03 | 18 |
GO:0050708 | Colorectum | AD | regulation of protein secretion | 83/3918 | 268/18723 | 6.59e-05 | 1.07e-03 | 83 |
GO:0005996 | Colorectum | AD | monosaccharide metabolic process | 80/3918 | 257/18723 | 7.31e-05 | 1.17e-03 | 80 |
GO:0072329 | Colorectum | AD | monocarboxylic acid catabolic process | 44/3918 | 122/18723 | 8.05e-05 | 1.28e-03 | 44 |
GO:0034440 | Colorectum | AD | lipid oxidation | 40/3918 | 108/18723 | 8.52e-05 | 1.32e-03 | 40 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04714 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa04152 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa04922 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa00071 | Colorectum | AD | Fatty acid degradation | 20/2092 | 43/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 20 |
hsa047141 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa041521 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa049221 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa000711 | Colorectum | AD | Fatty acid degradation | 20/2092 | 43/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 20 |
hsa047142 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa049222 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
hsa000712 | Colorectum | SER | Fatty acid degradation | 15/1580 | 43/8465 | 8.60e-03 | 4.26e-02 | 3.09e-02 | 15 |
hsa047143 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa049223 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
hsa000713 | Colorectum | SER | Fatty acid degradation | 15/1580 | 43/8465 | 8.60e-03 | 4.26e-02 | 3.09e-02 | 15 |
hsa047144 | Colorectum | MSS | Thermogenesis | 113/1875 | 232/8465 | 1.52e-19 | 4.62e-18 | 2.83e-18 | 113 |
hsa049224 | Colorectum | MSS | Glucagon signaling pathway | 39/1875 | 107/8465 | 5.00e-04 | 3.45e-03 | 2.11e-03 | 39 |
hsa041522 | Colorectum | MSS | AMPK signaling pathway | 41/1875 | 121/8465 | 1.91e-03 | 9.83e-03 | 6.03e-03 | 41 |
hsa04931 | Colorectum | MSS | Insulin resistance | 36/1875 | 108/8465 | 4.74e-03 | 2.01e-02 | 1.23e-02 | 36 |
hsa000714 | Colorectum | MSS | Fatty acid degradation | 17/1875 | 43/8465 | 7.50e-03 | 2.86e-02 | 1.75e-02 | 17 |
hsa047145 | Colorectum | MSS | Thermogenesis | 113/1875 | 232/8465 | 1.52e-19 | 4.62e-18 | 2.83e-18 | 113 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CPT1A | SNV | Missense_Mutation | c.1798G>T | p.Gly600Trp | p.G600W | P50416 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-44-6147-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CPT1A | SNV | Missense_Mutation | c.1701N>A | p.Asp567Glu | p.D567E | P50416 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-50-5049-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CPT1A | SNV | Missense_Mutation | c.1429N>T | p.Asp477Tyr | p.D477Y | P50416 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-50-6592-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CPT1A | SNV | Missense_Mutation | novel | c.266N>C | p.Arg89Pro | p.R89P | P50416 | protein_coding | tolerated(0.25) | benign(0.264) | TCGA-73-7498-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | pemetrexed | CR |
CPT1A | SNV | Missense_Mutation | novel | c.1949N>T | p.Gly650Val | p.G650V | P50416 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CPT1A | SNV | Missense_Mutation | c.1872N>C | p.Gln624His | p.Q624H | P50416 | protein_coding | tolerated(0.19) | benign(0.013) | TCGA-95-7944-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CPT1A | SNV | Missense_Mutation | novel | c.399N>A | p.His133Gln | p.H133Q | P50416 | protein_coding | tolerated(0.08) | probably_damaging(1) | TCGA-MN-A4N5-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CPT1A | SNV | Missense_Mutation | c.1643N>T | p.Ser548Phe | p.S548F | P50416 | protein_coding | tolerated(0.12) | possibly_damaging(0.477) | TCGA-33-4587-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | etoposide | PD | |
CPT1A | SNV | Missense_Mutation | c.305A>C | p.Lys102Thr | p.K102T | P50416 | protein_coding | tolerated(0.32) | benign(0.091) | TCGA-34-2600-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CPT1A | SNV | Missense_Mutation | rs200242711 | c.400N>T | p.Gly134Trp | p.G134W | P50416 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-34-5929-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1374 | CPT1A | DRUGGABLE GENOME, ENZYME | PERHEXILINE | PERHEXILINE | ||
1374 | CPT1A | DRUGGABLE GENOME, ENZYME | PERHEXILINE | PERHEXILINE | ||
1374 | CPT1A | DRUGGABLE GENOME, ENZYME | PROPIONYL-L-CARNITINE |
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