![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: COL19A1 |
Gene summary for COL19A1 |
![]() |
Gene information | Species | Human | Gene symbol | COL19A1 | Gene ID | 1310 |
Gene name | collagen type XIX alpha 1 chain | |
Gene Alias | COL9A1L | |
Cytomap | 6q13 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q14993 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1310 | COL19A1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.91e-11 | -3.58e-01 | 0.0155 |
1310 | COL19A1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.30e-04 | -3.30e-01 | -0.1088 |
1310 | COL19A1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.09e-08 | -3.33e-01 | -0.1954 |
1310 | COL19A1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.19e-07 | -3.15e-01 | -0.1464 |
1310 | COL19A1 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.11e-06 | -3.18e-01 | -0.1001 |
1310 | COL19A1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.04e-02 | -3.63e-01 | -0.0179 |
1310 | COL19A1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.21e-07 | -3.44e-01 | 0.096 |
1310 | COL19A1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.75e-06 | -3.39e-01 | 0.0674 |
1310 | COL19A1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.06e-11 | -3.53e-01 | 0.294 |
1310 | COL19A1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.67e-02 | -3.38e-01 | 0.281 |
1310 | COL19A1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.62e-11 | -3.37e-01 | 0.3859 |
1310 | COL19A1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.14e-08 | -3.23e-01 | 0.3005 |
1310 | COL19A1 | A002-C-010 | Human | Colorectum | FAP | 1.56e-05 | -1.47e-01 | 0.242 |
1310 | COL19A1 | A015-C-203 | Human | Colorectum | FAP | 7.69e-49 | 9.59e-01 | -0.1294 |
1310 | COL19A1 | A015-C-204 | Human | Colorectum | FAP | 1.47e-24 | 9.79e-01 | -0.0228 |
1310 | COL19A1 | A014-C-040 | Human | Colorectum | FAP | 2.30e-13 | 1.02e+00 | -0.1184 |
1310 | COL19A1 | A002-C-201 | Human | Colorectum | FAP | 7.94e-21 | 7.86e-01 | 0.0324 |
1310 | COL19A1 | A001-C-119 | Human | Colorectum | FAP | 1.25e-53 | 1.37e+00 | -0.1557 |
1310 | COL19A1 | A001-C-108 | Human | Colorectum | FAP | 3.02e-26 | 7.17e-01 | -0.0272 |
1310 | COL19A1 | A002-C-021 | Human | Colorectum | FAP | 2.49e-11 | 5.23e-01 | 0.1171 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0060537 | Colorectum | CRC | muscle tissue development | 63/2078 | 403/18723 | 3.17e-03 | 2.78e-02 | 63 |
GO:0014706 | Colorectum | CRC | striated muscle tissue development | 59/2078 | 384/18723 | 6.11e-03 | 4.47e-02 | 59 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COL19A1 | SNV | Missense_Mutation | rs755925878 | c.3026N>T | p.Pro1009Leu | p.P1009L | Q14993 | protein_coding | tolerated(0.46) | benign(0.012) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
COL19A1 | SNV | Missense_Mutation | c.191C>A | p.Ser64Tyr | p.S64Y | Q14993 | protein_coding | tolerated(0.13) | possibly_damaging(0.692) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
COL19A1 | SNV | Missense_Mutation | c.399N>G | p.Ile133Met | p.I133M | Q14993 | protein_coding | deleterious(0.02) | benign(0.106) | TCGA-AX-A06H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD | |
COL19A1 | SNV | Missense_Mutation | c.3313N>A | p.Pro1105Thr | p.P1105T | Q14993 | protein_coding | tolerated(0.06) | probably_damaging(0.997) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
COL19A1 | SNV | Missense_Mutation | novel | c.1901N>G | p.Gln634Arg | p.Q634R | Q14993 | protein_coding | tolerated(0.62) | benign(0.007) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
COL19A1 | SNV | Missense_Mutation | c.152N>C | p.Lys51Thr | p.K51T | Q14993 | protein_coding | tolerated(0.64) | benign(0.027) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
COL19A1 | SNV | Missense_Mutation | c.2085N>A | p.Phe695Leu | p.F695L | Q14993 | protein_coding | tolerated(0.7) | benign(0.075) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
COL19A1 | SNV | Missense_Mutation | c.1185N>G | p.Ile395Met | p.I395M | Q14993 | protein_coding | tolerated(0.26) | benign(0.009) | TCGA-B5-A11N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COL19A1 | SNV | Missense_Mutation | rs186826494 | c.622N>T | p.Arg208Trp | p.R208W | Q14993 | protein_coding | deleterious(0) | benign(0.402) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
COL19A1 | SNV | Missense_Mutation | novel | c.755A>T | p.Glu252Val | p.E252V | Q14993 | protein_coding | tolerated(0.28) | benign(0.003) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |