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Gene: COG2 |
Gene summary for COG2 |
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Gene information | Species | Human | Gene symbol | COG2 | Gene ID | 22796 |
Gene name | component of oligomeric golgi complex 2 | |
Gene Alias | CDG2Q | |
Cytomap | 1q42.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q14746 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22796 | COG2 | LZE4T | Human | Esophagus | ESCC | 9.55e-07 | 2.21e-01 | 0.0811 |
22796 | COG2 | LZE7T | Human | Esophagus | ESCC | 4.68e-07 | 3.36e-01 | 0.0667 |
22796 | COG2 | LZE24T | Human | Esophagus | ESCC | 3.90e-10 | 2.15e-01 | 0.0596 |
22796 | COG2 | P1T-E | Human | Esophagus | ESCC | 1.68e-08 | 2.82e-01 | 0.0875 |
22796 | COG2 | P2T-E | Human | Esophagus | ESCC | 1.06e-19 | 3.40e-01 | 0.1177 |
22796 | COG2 | P4T-E | Human | Esophagus | ESCC | 2.96e-09 | 1.85e-01 | 0.1323 |
22796 | COG2 | P5T-E | Human | Esophagus | ESCC | 8.26e-11 | 1.94e-01 | 0.1327 |
22796 | COG2 | P8T-E | Human | Esophagus | ESCC | 3.47e-12 | 1.99e-01 | 0.0889 |
22796 | COG2 | P9T-E | Human | Esophagus | ESCC | 7.53e-09 | 2.03e-01 | 0.1131 |
22796 | COG2 | P10T-E | Human | Esophagus | ESCC | 4.05e-26 | 4.03e-01 | 0.116 |
22796 | COG2 | P11T-E | Human | Esophagus | ESCC | 6.17e-08 | 2.77e-01 | 0.1426 |
22796 | COG2 | P12T-E | Human | Esophagus | ESCC | 8.82e-17 | 3.36e-01 | 0.1122 |
22796 | COG2 | P15T-E | Human | Esophagus | ESCC | 4.57e-15 | 3.94e-01 | 0.1149 |
22796 | COG2 | P16T-E | Human | Esophagus | ESCC | 1.02e-15 | 2.85e-01 | 0.1153 |
22796 | COG2 | P17T-E | Human | Esophagus | ESCC | 2.01e-09 | 2.38e-01 | 0.1278 |
22796 | COG2 | P19T-E | Human | Esophagus | ESCC | 1.94e-03 | 2.19e-01 | 0.1662 |
22796 | COG2 | P20T-E | Human | Esophagus | ESCC | 3.73e-11 | 2.13e-01 | 0.1124 |
22796 | COG2 | P21T-E | Human | Esophagus | ESCC | 1.88e-16 | 3.10e-01 | 0.1617 |
22796 | COG2 | P22T-E | Human | Esophagus | ESCC | 1.02e-09 | 1.75e-01 | 0.1236 |
22796 | COG2 | P23T-E | Human | Esophagus | ESCC | 1.15e-18 | 3.82e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:00070308 | Esophagus | ESCC | Golgi organization | 101/8552 | 157/18723 | 1.78e-06 | 2.10e-05 | 101 |
GO:00068914 | Esophagus | ESCC | intra-Golgi vesicle-mediated transport | 26/8552 | 33/18723 | 1.06e-04 | 7.43e-04 | 26 |
GO:004819321 | Liver | HCC | Golgi vesicle transport | 217/7958 | 296/18723 | 2.58e-27 | 1.02e-24 | 217 |
GO:00070302 | Liver | HCC | Golgi organization | 99/7958 | 157/18723 | 1.54e-07 | 2.85e-06 | 99 |
GO:0006891 | Liver | HCC | intra-Golgi vesicle-mediated transport | 22/7958 | 33/18723 | 4.38e-03 | 1.90e-02 | 22 |
GO:004819315 | Oral cavity | OSCC | Golgi vesicle transport | 209/7305 | 296/18723 | 1.39e-28 | 6.30e-26 | 209 |
GO:00070307 | Oral cavity | OSCC | Golgi organization | 92/7305 | 157/18723 | 4.96e-07 | 7.27e-06 | 92 |
GO:00068913 | Oral cavity | OSCC | intra-Golgi vesicle-mediated transport | 23/7305 | 33/18723 | 3.47e-04 | 2.12e-03 | 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COG2 | insertion | Nonsense_Mutation | novel | c.706_707insACAGATAATGACATATATAAAAT | p.Thr236AsnfsTer3 | p.T236Nfs*3 | Q14746 | protein_coding | TCGA-HD-8635-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
COG2 | SNV | Missense_Mutation | rs376181628 | c.595C>T | p.Arg199Cys | p.R199C | Q14746 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
COG2 | SNV | Missense_Mutation | rs199727575 | c.413N>A | p.Arg138Gln | p.R138Q | Q14746 | protein_coding | tolerated(0.68) | benign(0.012) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
COG2 | SNV | Missense_Mutation | c.1083N>T | p.Gln361His | p.Q361H | Q14746 | protein_coding | deleterious(0) | possibly_damaging(0.907) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COG2 | SNV | Missense_Mutation | novel | c.701A>C | p.Tyr234Ser | p.Y234S | Q14746 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-HF-7134-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
COG2 | SNV | Missense_Mutation | novel | c.2171N>G | p.Glu724Gly | p.E724G | Q14746 | protein_coding | deleterious(0.02) | possibly_damaging(0.629) | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
COG2 | SNV | Missense_Mutation | rs199855667 | c.872N>A | p.Arg291Gln | p.R291Q | Q14746 | protein_coding | tolerated(0.1) | benign(0.229) | TCGA-ZQ-A9CR-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
COG2 | insertion | In_Frame_Ins | novel | c.998_999insAAAAACCGTATTTGTAAT | p.Asn333delinsLysLysThrValPheValIle | p.N333delinsKKTVFVI | Q14746 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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