![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CNTN3 |
Gene summary for CNTN3 |
![]() |
Gene information | Species | Human | Gene symbol | CNTN3 | Gene ID | 5067 |
Gene name | contactin 3 | |
Gene Alias | BIG-1 | |
Cytomap | 3p12.3 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | Q9P232 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5067 | CNTN3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.14e-23 | -6.96e-01 | 0.0155 |
5067 | CNTN3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.05e-13 | -7.54e-01 | -0.1808 |
5067 | CNTN3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.00e-04 | -8.29e-01 | 0.0216 |
5067 | CNTN3 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.22e-03 | -4.28e-01 | -0.1088 |
5067 | CNTN3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.99e-11 | -7.47e-01 | -0.1207 |
5067 | CNTN3 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.18e-20 | -5.96e-01 | -0.1464 |
5067 | CNTN3 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.49e-05 | -3.62e-01 | -0.1001 |
5067 | CNTN3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.15e-05 | -4.57e-01 | -0.059 |
5067 | CNTN3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.61e-04 | -7.46e-01 | -0.2061 |
5067 | CNTN3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 9.33e-05 | -8.61e-01 | -0.1462 |
5067 | CNTN3 | HTA11_546_2000001011 | Human | Colorectum | AD | 9.75e-04 | -5.46e-01 | -0.0842 |
5067 | CNTN3 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.15e-21 | -7.49e-01 | 0.096 |
5067 | CNTN3 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.79e-02 | -8.00e-01 | 0.0451 |
5067 | CNTN3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.07e-05 | -7.77e-01 | 0.0528 |
5067 | CNTN3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.65e-04 | -4.77e-01 | 0.0338 |
5067 | CNTN3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.81e-20 | -5.78e-01 | 0.0674 |
5067 | CNTN3 | HTA11_6818_2000001011 | Human | Colorectum | AD | 7.75e-03 | -6.17e-01 | 0.0112 |
5067 | CNTN3 | HTA11_11156_2000001011 | Human | Colorectum | AD | 2.99e-02 | -8.64e-01 | 0.0397 |
5067 | CNTN3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.55e-09 | -6.84e-01 | 0.0588 |
5067 | CNTN3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.42e-56 | -9.27e-01 | 0.294 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CNTN3 | SNV | Missense_Mutation | novel | c.2101N>A | p.Glu701Lys | p.E701K | Q9P232 | protein_coding | tolerated(0.7) | benign(0.056) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CNTN3 | SNV | Missense_Mutation | rs148089886 | c.1936N>A | p.Val646Ile | p.V646I | Q9P232 | protein_coding | deleterious(0.04) | benign(0.362) | TCGA-D1-A163-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | SD |
CNTN3 | SNV | Missense_Mutation | c.832N>A | p.Phe278Ile | p.F278I | Q9P232 | protein_coding | deleterious(0) | possibly_damaging(0.694) | TCGA-D1-A17H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CNTN3 | SNV | Missense_Mutation | novel | c.2002N>C | p.Trp668Arg | p.W668R | Q9P232 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-DF-A2KV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CNTN3 | SNV | Missense_Mutation | novel | c.388N>G | p.Ser130Gly | p.S130G | Q9P232 | protein_coding | tolerated(0.17) | benign(0.155) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
CNTN3 | SNV | Missense_Mutation | novel | c.3083N>T | p.Trp1028Leu | p.W1028L | Q9P232 | protein_coding | deleterious_low_confidence(0.01) | benign(0.058) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CNTN3 | SNV | Missense_Mutation | novel | c.283N>G | p.Thr95Ala | p.T95A | Q9P232 | protein_coding | tolerated(1) | benign(0.001) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CNTN3 | SNV | Missense_Mutation | c.2020N>T | p.Arg674Trp | p.R674W | Q9P232 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
CNTN3 | SNV | Missense_Mutation | novel | c.511N>T | p.Arg171Trp | p.R171W | Q9P232 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
CNTN3 | SNV | Missense_Mutation | novel | c.1196N>T | p.Ala399Val | p.A399V | Q9P232 | protein_coding | deleterious(0.02) | probably_damaging(0.979) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |