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Gene: CLIP2 |
Gene summary for CLIP2 |
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Gene information | Species | Human | Gene symbol | CLIP2 | Gene ID | 7461 |
Gene name | CAP-Gly domain containing linker protein 2 | |
Gene Alias | CLIP | |
Cytomap | 7q11.23 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | A0A140VJG6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7461 | CLIP2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.42e-02 | 5.29e-01 | -0.1808 |
7461 | CLIP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.82e-08 | 5.67e-01 | -0.1954 |
7461 | CLIP2 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.92e-02 | 7.78e-01 | -0.2602 |
7461 | CLIP2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.26e-07 | 1.09e+00 | -0.2196 |
7461 | CLIP2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.58e-04 | 6.28e-01 | -0.1207 |
7461 | CLIP2 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.16e-07 | 7.59e-01 | -0.1526 |
7461 | CLIP2 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.95e-17 | 8.66e-01 | -0.1464 |
7461 | CLIP2 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.77e-02 | 4.35e-01 | -0.1001 |
7461 | CLIP2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.67e-04 | 5.78e-01 | -0.059 |
7461 | CLIP2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.18e-04 | -2.82e-01 | 0.294 |
7461 | CLIP2 | A002-C-010 | Human | Colorectum | FAP | 1.11e-02 | -9.17e-02 | 0.242 |
7461 | CLIP2 | A015-C-203 | Human | Colorectum | FAP | 2.52e-23 | -4.48e-02 | -0.1294 |
7461 | CLIP2 | A002-C-201 | Human | Colorectum | FAP | 9.48e-07 | -1.36e-01 | 0.0324 |
7461 | CLIP2 | A002-C-203 | Human | Colorectum | FAP | 1.43e-04 | -1.36e-01 | 0.2786 |
7461 | CLIP2 | A001-C-108 | Human | Colorectum | FAP | 1.09e-15 | -2.06e-02 | -0.0272 |
7461 | CLIP2 | A002-C-205 | Human | Colorectum | FAP | 3.75e-14 | -4.34e-02 | -0.1236 |
7461 | CLIP2 | A001-C-104 | Human | Colorectum | FAP | 3.23e-03 | -5.74e-02 | 0.0184 |
7461 | CLIP2 | A015-C-005 | Human | Colorectum | FAP | 2.84e-05 | -3.29e-01 | -0.0336 |
7461 | CLIP2 | A015-C-006 | Human | Colorectum | FAP | 1.61e-08 | 1.78e-02 | -0.0994 |
7461 | CLIP2 | A015-C-106 | Human | Colorectum | FAP | 3.12e-10 | -8.65e-02 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0031122 | Colorectum | FAP | cytoplasmic microtubule organization | 17/2622 | 56/18723 | 1.24e-03 | 1.16e-02 | 17 |
GO:00311221 | Colorectum | CRC | cytoplasmic microtubule organization | 16/2078 | 56/18723 | 2.72e-04 | 4.37e-03 | 16 |
GO:00311227 | Esophagus | ESCC | cytoplasmic microtubule organization | 38/8552 | 56/18723 | 6.60e-04 | 3.50e-03 | 38 |
GO:00311222 | Liver | HCC | cytoplasmic microtubule organization | 35/7958 | 56/18723 | 2.00e-03 | 1.01e-02 | 35 |
GO:00311225 | Prostate | BPH | cytoplasmic microtubule organization | 22/3107 | 56/18723 | 4.21e-05 | 4.48e-04 | 22 |
GO:00311229 | Thyroid | PTC | cytoplasmic microtubule organization | 34/5968 | 56/18723 | 8.20e-06 | 9.42e-05 | 34 |
GO:003112215 | Thyroid | ATC | cytoplasmic microtubule organization | 34/6293 | 56/18723 | 2.92e-05 | 2.45e-04 | 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLIP2 | SNV | Missense_Mutation | rs767479757 | c.2237C>T | p.Ala746Val | p.A746V | Q9UDT6 | protein_coding | tolerated(0.12) | benign(0.026) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
CLIP2 | SNV | Missense_Mutation | novel | c.2714N>C | p.Lys905Thr | p.K905T | Q9UDT6 | protein_coding | deleterious(0.01) | benign(0.03) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLIP2 | SNV | Missense_Mutation | novel | c.821C>T | p.Pro274Leu | p.P274L | Q9UDT6 | protein_coding | deleterious(0.03) | probably_damaging(0.983) | TCGA-SJ-A6ZI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLIP2 | insertion | Frame_Shift_Ins | novel | c.24_25insCC | p.Gly11ProfsTer78 | p.G11Pfs*78 | Q9UDT6 | protein_coding | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | ||
CLIP2 | SNV | Missense_Mutation | rs782207729 | c.169N>A | p.Ala57Thr | p.A57T | Q9UDT6 | protein_coding | tolerated(0.32) | benign(0) | TCGA-RC-A6M4-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CLIP2 | SNV | Missense_Mutation | c.715G>T | p.Gly239Trp | p.G239W | Q9UDT6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-49-4507-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD | |
CLIP2 | SNV | Missense_Mutation | novel | c.754G>A | p.Glu252Lys | p.E252K | Q9UDT6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLIP2 | SNV | Missense_Mutation | c.2857N>A | p.Leu953Met | p.L953M | Q9UDT6 | protein_coding | tolerated(0.22) | probably_damaging(0.997) | TCGA-50-5933-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR | |
CLIP2 | SNV | Missense_Mutation | c.884C>G | p.Pro295Arg | p.P295R | Q9UDT6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-50-8457-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CLIP2 | SNV | Missense_Mutation | novel | c.120N>T | p.Glu40Asp | p.E40D | Q9UDT6 | protein_coding | tolerated(0.14) | benign(0.22) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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