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Gene: CHM |
Gene summary for CHM |
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Gene information | Species | Human | Gene symbol | CHM | Gene ID | 1121 |
Gene name | CHM Rab escort protein | |
Gene Alias | DXS540 | |
Cytomap | Xq21.2 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | A8K545 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1121 | CHM | LZE5T | Human | Esophagus | ESCC | 1.58e-03 | 2.27e-01 | 0.0514 |
1121 | CHM | LZE7T | Human | Esophagus | ESCC | 6.50e-03 | 3.43e-01 | 0.0667 |
1121 | CHM | LZE8T | Human | Esophagus | ESCC | 2.27e-02 | 9.67e-02 | 0.067 |
1121 | CHM | LZE24T | Human | Esophagus | ESCC | 1.04e-13 | 2.99e-01 | 0.0596 |
1121 | CHM | LZE6T | Human | Esophagus | ESCC | 3.49e-02 | 1.79e-01 | 0.0845 |
1121 | CHM | P2T-E | Human | Esophagus | ESCC | 2.47e-48 | 7.68e-01 | 0.1177 |
1121 | CHM | P4T-E | Human | Esophagus | ESCC | 1.39e-13 | 2.67e-01 | 0.1323 |
1121 | CHM | P5T-E | Human | Esophagus | ESCC | 5.18e-06 | 9.88e-02 | 0.1327 |
1121 | CHM | P8T-E | Human | Esophagus | ESCC | 4.20e-14 | 2.73e-01 | 0.0889 |
1121 | CHM | P9T-E | Human | Esophagus | ESCC | 1.61e-07 | 1.31e-01 | 0.1131 |
1121 | CHM | P10T-E | Human | Esophagus | ESCC | 3.28e-17 | 3.07e-01 | 0.116 |
1121 | CHM | P11T-E | Human | Esophagus | ESCC | 2.15e-05 | 2.97e-01 | 0.1426 |
1121 | CHM | P12T-E | Human | Esophagus | ESCC | 1.02e-16 | 3.29e-01 | 0.1122 |
1121 | CHM | P15T-E | Human | Esophagus | ESCC | 1.24e-12 | 1.27e-01 | 0.1149 |
1121 | CHM | P16T-E | Human | Esophagus | ESCC | 3.82e-06 | 1.34e-01 | 0.1153 |
1121 | CHM | P17T-E | Human | Esophagus | ESCC | 3.52e-04 | 2.60e-01 | 0.1278 |
1121 | CHM | P19T-E | Human | Esophagus | ESCC | 4.69e-02 | 1.92e-01 | 0.1662 |
1121 | CHM | P20T-E | Human | Esophagus | ESCC | 1.78e-05 | 1.65e-01 | 0.1124 |
1121 | CHM | P21T-E | Human | Esophagus | ESCC | 1.63e-09 | 1.19e-01 | 0.1617 |
1121 | CHM | P22T-E | Human | Esophagus | ESCC | 1.28e-07 | 1.89e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160329 | Breast | Precancer | viral process | 58/1080 | 415/18723 | 3.42e-10 | 3.16e-08 | 58 |
GO:00190589 | Breast | Precancer | viral life cycle | 47/1080 | 317/18723 | 2.42e-09 | 1.99e-07 | 47 |
GO:00444039 | Breast | Precancer | biological process involved in symbiotic interaction | 42/1080 | 290/18723 | 3.40e-08 | 2.11e-06 | 42 |
GO:00521269 | Breast | Precancer | movement in host environment | 29/1080 | 175/18723 | 2.59e-07 | 1.28e-05 | 29 |
GO:00517019 | Breast | Precancer | biological process involved in interaction with host | 31/1080 | 203/18723 | 6.52e-07 | 2.71e-05 | 31 |
GO:00507929 | Breast | Precancer | regulation of viral process | 27/1080 | 164/18723 | 7.59e-07 | 3.05e-05 | 27 |
GO:00439039 | Breast | Precancer | regulation of biological process involved in symbiotic interaction | 15/1080 | 72/18723 | 1.23e-05 | 3.17e-04 | 15 |
GO:19039009 | Breast | Precancer | regulation of viral life cycle | 23/1080 | 148/18723 | 1.31e-05 | 3.30e-04 | 23 |
GO:00485249 | Breast | Precancer | positive regulation of viral process | 12/1080 | 65/18723 | 3.00e-04 | 4.34e-03 | 12 |
GO:00224119 | Breast | Precancer | cellular component disassembly | 44/1080 | 443/18723 | 3.17e-04 | 4.51e-03 | 44 |
GO:19035434 | Breast | Precancer | positive regulation of exosomal secretion | 5/1080 | 15/18723 | 1.17e-03 | 1.26e-02 | 5 |
GO:19035416 | Breast | Precancer | regulation of exosomal secretion | 5/1080 | 17/18723 | 2.19e-03 | 2.06e-02 | 5 |
GO:19901826 | Breast | Precancer | exosomal secretion | 5/1080 | 20/18723 | 4.74e-03 | 3.61e-02 | 5 |
GO:19039026 | Breast | Precancer | positive regulation of viral life cycle | 6/1080 | 29/18723 | 5.49e-03 | 4.01e-02 | 6 |
GO:00977346 | Breast | Precancer | extracellular exosome biogenesis | 5/1080 | 21/18723 | 5.93e-03 | 4.21e-02 | 5 |
GO:001603214 | Breast | IDC | viral process | 75/1434 | 415/18723 | 1.98e-12 | 4.02e-10 | 75 |
GO:001905814 | Breast | IDC | viral life cycle | 61/1434 | 317/18723 | 1.61e-11 | 2.77e-09 | 61 |
GO:004440314 | Breast | IDC | biological process involved in symbiotic interaction | 52/1434 | 290/18723 | 6.55e-09 | 5.03e-07 | 52 |
GO:005079214 | Breast | IDC | regulation of viral process | 36/1434 | 164/18723 | 6.55e-09 | 5.03e-07 | 36 |
GO:190390014 | Breast | IDC | regulation of viral life cycle | 30/1434 | 148/18723 | 7.25e-07 | 3.35e-05 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHM | SNV | Missense_Mutation | novel | c.283N>G | p.Ile95Val | p.I95V | P24386 | protein_coding | tolerated(0.11) | benign(0.409) | TCGA-05-4244-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
CHM | SNV | Missense_Mutation | c.1691N>T | p.Cys564Phe | p.C564F | P24386 | protein_coding | tolerated(0.37) | benign(0.026) | TCGA-44-7670-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
CHM | SNV | Missense_Mutation | c.1270N>T | p.Gly424Cys | p.G424C | P24386 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-44-8120-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CHM | SNV | Missense_Mutation | novel | c.806G>T | p.Gly269Val | p.G269V | P24386 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-50-5931-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CHM | SNV | Missense_Mutation | c.1271N>T | p.Gly424Val | p.G424V | P24386 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-55-6972-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CHM | SNV | Missense_Mutation | c.1917N>A | p.Phe639Leu | p.F639L | P24386 | protein_coding | tolerated(0.68) | benign(0) | TCGA-55-7995-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
CHM | SNV | Missense_Mutation | rs140566714 | c.589N>G | p.Ser197Gly | p.S197G | P24386 | protein_coding | tolerated(0.51) | benign(0) | TCGA-62-A471-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
CHM | SNV | Missense_Mutation | c.250N>C | p.Glu84Gln | p.E84Q | P24386 | protein_coding | deleterious(0.02) | benign(0.422) | TCGA-64-5775-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
CHM | SNV | Missense_Mutation | c.1853N>T | p.Gly618Val | p.G618V | P24386 | protein_coding | deleterious(0.01) | possibly_damaging(0.875) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHM | SNV | Missense_Mutation | novel | c.800N>T | p.Arg267Leu | p.R267L | P24386 | protein_coding | tolerated(0.51) | benign(0.291) | TCGA-73-4666-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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