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Gene: CFAP44 |
Gene summary for CFAP44 |
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Gene information | Species | Human | Gene symbol | CFAP44 | Gene ID | 55779 |
Gene name | cilia and flagella associated protein 44 | |
Gene Alias | SPGF20 | |
Cytomap | 3q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q96MT7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55779 | CFAP44 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.40e-19 | -5.84e-01 | 0.0155 |
55779 | CFAP44 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.24e-10 | -5.76e-01 | -0.1808 |
55779 | CFAP44 | HTA11_2951_2000001011 | Human | Colorectum | AD | 6.45e-03 | -6.06e-01 | 0.0216 |
55779 | CFAP44 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.83e-07 | -5.67e-01 | -0.0811 |
55779 | CFAP44 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.75e-14 | -5.89e-01 | -0.1088 |
55779 | CFAP44 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.14e-15 | -5.36e-01 | -0.1954 |
55779 | CFAP44 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.39e-02 | -6.06e-01 | -0.2196 |
55779 | CFAP44 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.50e-09 | -5.93e-01 | -0.1207 |
55779 | CFAP44 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.64e-06 | -5.75e-01 | -0.1526 |
55779 | CFAP44 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.82e-27 | -5.93e-01 | -0.1464 |
55779 | CFAP44 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.06e-22 | -5.61e-01 | -0.1001 |
55779 | CFAP44 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.26e-14 | -5.70e-01 | -0.059 |
55779 | CFAP44 | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.68e-05 | -6.06e-01 | -0.2061 |
55779 | CFAP44 | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.45e-03 | -6.06e-01 | -0.1462 |
55779 | CFAP44 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.75e-08 | -6.06e-01 | -0.0842 |
55779 | CFAP44 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.05e-06 | -6.06e-01 | -0.0179 |
55779 | CFAP44 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.26e-18 | -5.86e-01 | 0.096 |
55779 | CFAP44 | HTA11_4255_2000001011 | Human | Colorectum | SER | 6.45e-03 | -6.06e-01 | 0.0446 |
55779 | CFAP44 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.06e-05 | -6.06e-01 | 0.0528 |
55779 | CFAP44 | HTA11_10623_2000001011 | Human | Colorectum | AD | 8.38e-04 | -5.84e-01 | -0.0177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFAP44 | SNV | Missense_Mutation | novel | c.4613N>A | p.Ser1538Tyr | p.S1538Y | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CFAP44 | SNV | Missense_Mutation | novel | c.3320N>A | p.Pro1107His | p.P1107H | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CFAP44 | SNV | Missense_Mutation | c.1009N>A | p.Leu337Ile | p.L337I | protein_coding | tolerated(0.38) | possibly_damaging(0.58) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CFAP44 | SNV | Missense_Mutation | novel | c.3919C>A | p.Leu1307Ile | p.L1307I | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CFAP44 | SNV | Missense_Mutation | novel | c.3060N>T | p.Lys1020Asn | p.K1020N | protein_coding | deleterious(0) | benign(0.003) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CFAP44 | SNV | Missense_Mutation | novel | c.2938N>G | p.Phe980Val | p.F980V | protein_coding | deleterious(0) | possibly_damaging(0.852) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CFAP44 | SNV | Missense_Mutation | rs748793444 | c.671N>A | p.Arg224Gln | p.R224Q | protein_coding | tolerated(0.16) | benign(0.011) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
CFAP44 | SNV | Missense_Mutation | rs781687661 | c.1655C>T | p.Thr552Met | p.T552M | protein_coding | tolerated(0.14) | benign(0.259) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CFAP44 | SNV | Missense_Mutation | novel | c.5152N>A | p.Leu1718Ile | p.L1718I | protein_coding | deleterious(0.03) | possibly_damaging(0.86) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
CFAP44 | SNV | Missense_Mutation | novel | c.1298N>G | p.Glu433Gly | p.E433G | protein_coding | tolerated(0.12) | possibly_damaging(0.699) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55779 | CFAP44 | PROTEASE | hmg coa reductase inhibitors | 25602530 |
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