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Gene: CADM2 |
Gene summary for CADM2 |
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Gene information | Species | Human | Gene symbol | CADM2 | Gene ID | 253559 |
Gene name | cell adhesion molecule 2 | |
Gene Alias | IGSF4D | |
Cytomap | 3p12.1 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | Q8N3J6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
253559 | CADM2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.68e-03 | 3.20e-01 | -0.0811 |
253559 | CADM2 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.84e-04 | 2.50e-01 | -0.1088 |
253559 | CADM2 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.23e-06 | 3.66e-01 | -0.1526 |
253559 | CADM2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.31e-07 | 5.05e-01 | -0.1706 |
253559 | CADM2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.40e-02 | 3.01e-01 | -0.2061 |
253559 | CADM2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.12e-03 | 3.19e-01 | 0.0112 |
253559 | CADM2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.89e-10 | 3.49e-01 | 0.294 |
253559 | CADM2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.02e-02 | 4.95e-01 | 0.3487 |
253559 | CADM2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.48e-09 | 3.17e-01 | 0.3859 |
253559 | CADM2 | LP16 | Human | Oral cavity | LP | 4.93e-06 | 8.14e-01 | 0.1055 |
253559 | CADM2 | HTA12-15-2 | Human | Pancreas | PDAC | 4.06e-02 | 4.13e-01 | 0.2315 |
253559 | CADM2 | HTA12-23-1 | Human | Pancreas | PDAC | 2.25e-04 | 6.45e-01 | 0.3405 |
253559 | CADM2 | HTA12-25-1 | Human | Pancreas | PDAC | 3.52e-06 | 5.82e-01 | 0.313 |
253559 | CADM2 | HTA12-26-1 | Human | Pancreas | PDAC | 9.77e-13 | 7.76e-01 | 0.3728 |
253559 | CADM2 | HTA12-29-1 | Human | Pancreas | PDAC | 4.14e-35 | 9.82e-01 | 0.3722 |
253559 | CADM2 | HTA12-9-3 | Human | Pancreas | PDAC | 5.47e-06 | 7.68e-01 | 0.2045 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CADM2 | SNV | Missense_Mutation | novel | c.644N>G | p.Thr215Ser | p.T215S | Q8N3J6 | protein_coding | tolerated(1) | benign(0.006) | TCGA-CR-6474-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unspecific | PD | |
CADM2 | SNV | Missense_Mutation | novel | c.15N>A | p.Phe5Leu | p.F5L | Q8N3J6 | protein_coding | tolerated(0.49) | benign(0) | TCGA-CR-7372-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CADM2 | SNV | Missense_Mutation | novel | c.467N>A | p.Ala156Glu | p.A156E | Q8N3J6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CV-5442-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CADM2 | SNV | Missense_Mutation | novel | c.546N>C | p.Lys182Asn | p.K182N | Q8N3J6 | protein_coding | deleterious(0) | possibly_damaging(0.877) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CADM2 | SNV | Missense_Mutation | novel | c.746C>A | p.Thr249Asn | p.T249N | Q8N3J6 | protein_coding | tolerated(0.12) | benign(0.173) | TCGA-DQ-5629-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD |
CADM2 | SNV | Missense_Mutation | novel | c.331N>T | p.Met111Leu | p.M111L | Q8N3J6 | protein_coding | tolerated(0.16) | probably_damaging(0.988) | TCGA-H7-7774-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CADM2 | SNV | Missense_Mutation | c.1142T>G | p.Phe381Cys | p.F381C | Q8N3J6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G9-6384-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
CADM2 | SNV | Missense_Mutation | novel | c.194N>T | p.Thr65Ile | p.T65I | Q8N3J6 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
CADM2 | SNV | Missense_Mutation | rs752725804 | c.1070A>G | p.Asp357Gly | p.D357G | Q8N3J6 | protein_coding | deleterious(0.01) | benign(0.178) | TCGA-B7-5818-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CADM2 | SNV | Missense_Mutation | novel | c.256N>A | p.Trp86Arg | p.W86R | Q8N3J6 | protein_coding | tolerated(0.08) | possibly_damaging(0.627) | TCGA-BR-7704-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
253559 | CADM2 | NA | ethanol | ALCOHOL | 32451486 |
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