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Gene: C16orf96 |
Gene summary for C16ORF96 |
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Gene information | Species | Human | Gene symbol | C16orf96 | Gene ID | 342346 |
Gene name | chromosome 16 open reading frame 96 | |
Gene Alias | C16orf96 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | A6NNT2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
342346 | C16orf96 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.98e-03 | 9.20e-02 | 0.0155 |
342346 | C16orf96 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.42e-05 | 1.66e-01 | -0.1808 |
342346 | C16orf96 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.27e-05 | 1.81e-01 | -0.0811 |
342346 | C16orf96 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.02e-04 | 1.63e-01 | -0.1088 |
342346 | C16orf96 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.56e-12 | 2.60e-01 | -0.1954 |
342346 | C16orf96 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.61e-03 | 2.88e-01 | -0.2602 |
342346 | C16orf96 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.22e-02 | 2.41e-01 | -0.1207 |
342346 | C16orf96 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.64e-05 | 2.13e-01 | -0.1526 |
342346 | C16orf96 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.30e-10 | 2.80e-01 | -0.059 |
342346 | C16orf96 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.94e-06 | 2.82e-01 | -0.1706 |
342346 | C16orf96 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.34e-04 | 3.57e-01 | -0.1462 |
342346 | C16orf96 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.44e-03 | 1.63e-01 | -0.0842 |
342346 | C16orf96 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.96e-03 | 1.74e-01 | -0.0179 |
342346 | C16orf96 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.04e-08 | 2.06e-01 | 0.096 |
342346 | C16orf96 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.45e-03 | 2.21e-01 | 0.0528 |
342346 | C16orf96 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.93e-13 | 3.92e-01 | 0.0588 |
342346 | C16orf96 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.34e-09 | 2.37e-01 | 0.294 |
342346 | C16orf96 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.89e-11 | 8.82e-01 | 0.3487 |
342346 | C16orf96 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.31e-09 | 3.06e-01 | 0.3859 |
342346 | C16orf96 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.14e-04 | 1.79e-01 | 0.2585 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C16orf96 | SNV | Missense_Mutation | novel | c.470T>C | p.Val157Ala | p.V157A | A6NNT2 | protein_coding | tolerated(0.59) | benign(0.003) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
C16orf96 | SNV | Missense_Mutation | novel | c.2274A>C | p.Gln758His | p.Q758H | A6NNT2 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
C16orf96 | SNV | Missense_Mutation | novel | c.1879N>T | p.Gly627Trp | p.G627W | A6NNT2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C16orf96 | SNV | Missense_Mutation | rs555611882 | c.2725N>T | p.Arg909Cys | p.R909C | A6NNT2 | protein_coding | deleterious(0) | possibly_damaging(0.707) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C16orf96 | SNV | Missense_Mutation | rs757028753 | c.2830N>A | p.Ala944Thr | p.A944T | A6NNT2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C16orf96 | SNV | Missense_Mutation | rs146734619 | c.1978G>A | p.Asp660Asn | p.D660N | A6NNT2 | protein_coding | tolerated(0.4) | benign(0.006) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
C16orf96 | SNV | Missense_Mutation | novel | c.2702G>T | p.Gly901Val | p.G901V | A6NNT2 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
C16orf96 | SNV | Missense_Mutation | c.2792G>A | p.Arg931His | p.R931H | A6NNT2 | protein_coding | tolerated(0.05) | benign(0.398) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |
C16orf96 | SNV | Missense_Mutation | novel | c.118G>A | p.Ala40Thr | p.A40T | A6NNT2 | protein_coding | tolerated(0.16) | benign(0.111) | TCGA-SL-A6JA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C16orf96 | SNV | Missense_Mutation | c.761N>T | p.Gln254Leu | p.Q254L | A6NNT2 | protein_coding | deleterious(0) | possibly_damaging(0.882) | TCGA-CC-A7IH-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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