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Gene: BICD1 |
Gene summary for BICD1 |
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Gene information | Species | Human | Gene symbol | BICD1 | Gene ID | 636 |
Gene name | BICD cargo adaptor 1 | |
Gene Alias | BICD | |
Cytomap | 12p11.21 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q96G01 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
636 | BICD1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.29e-05 | 5.53e-01 | -0.059 |
636 | BICD1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.94e-06 | 3.01e-01 | 0.0674 |
636 | BICD1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 3.88e-06 | 1.25e+00 | 0.3487 |
636 | BICD1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.95e-03 | 2.81e-01 | 0.3005 |
636 | BICD1 | A002-C-203 | Human | Colorectum | FAP | 5.56e-03 | 4.10e-01 | 0.2786 |
636 | BICD1 | CRC-1-8810 | Human | Colorectum | CRC | 4.42e-06 | 4.55e-01 | 0.6257 |
636 | BICD1 | AEH-subject1 | Human | Endometrium | AEH | 1.55e-29 | 7.17e-01 | -0.3059 |
636 | BICD1 | AEH-subject2 | Human | Endometrium | AEH | 5.14e-05 | 2.49e-01 | -0.2525 |
636 | BICD1 | EEC-subject1 | Human | Endometrium | EEC | 9.66e-19 | 5.88e-01 | -0.2682 |
636 | BICD1 | EEC-subject3 | Human | Endometrium | EEC | 1.46e-10 | 2.18e-01 | -0.2525 |
636 | BICD1 | EEC-subject5 | Human | Endometrium | EEC | 1.35e-10 | 4.36e-01 | -0.249 |
636 | BICD1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.58e-08 | -3.37e-02 | -0.1869 |
636 | BICD1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.59e-07 | -4.26e-02 | -0.1875 |
636 | BICD1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 9.35e-11 | -6.70e-02 | -0.1883 |
636 | BICD1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 5.85e-10 | -2.08e-01 | -0.1934 |
636 | BICD1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 5.84e-12 | -1.98e-01 | -0.1917 |
636 | BICD1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 6.08e-13 | -1.51e-01 | -0.1916 |
636 | BICD1 | LZE4T | Human | Esophagus | ESCC | 1.15e-07 | 2.17e-01 | 0.0811 |
636 | BICD1 | LZE7T | Human | Esophagus | ESCC | 1.01e-06 | 3.90e-01 | 0.0667 |
636 | BICD1 | LZE20T | Human | Esophagus | ESCC | 4.34e-03 | 1.40e-01 | 0.0662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:1903829 | Colorectum | AD | positive regulation of cellular protein localization | 110/3918 | 276/18723 | 4.58e-13 | 8.44e-11 | 110 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0006403 | Colorectum | AD | RNA localization | 71/3918 | 201/18723 | 1.54e-06 | 4.76e-05 | 71 |
GO:0006898 | Colorectum | AD | receptor-mediated endocytosis | 76/3918 | 244/18723 | 1.07e-04 | 1.59e-03 | 76 |
GO:0030100 | Colorectum | AD | regulation of endocytosis | 67/3918 | 211/18723 | 1.42e-04 | 2.01e-03 | 67 |
GO:0071539 | Colorectum | AD | protein localization to centrosome | 16/3918 | 33/18723 | 3.86e-04 | 4.41e-03 | 16 |
GO:0030705 | Colorectum | AD | cytoskeleton-dependent intracellular transport | 60/3918 | 195/18723 | 7.56e-04 | 7.59e-03 | 60 |
GO:0045807 | Colorectum | AD | positive regulation of endocytosis | 35/3918 | 100/18723 | 7.78e-04 | 7.78e-03 | 35 |
GO:1905508 | Colorectum | AD | protein localization to microtubule organizing center | 16/3918 | 35/18723 | 8.76e-04 | 8.51e-03 | 16 |
GO:0048260 | Colorectum | AD | positive regulation of receptor-mediated endocytosis | 20/3918 | 52/18723 | 2.87e-03 | 2.14e-02 | 20 |
GO:0048259 | Colorectum | AD | regulation of receptor-mediated endocytosis | 35/3918 | 110/18723 | 4.85e-03 | 3.27e-02 | 35 |
GO:0072384 | Colorectum | AD | organelle transport along microtubule | 28/3918 | 85/18723 | 6.55e-03 | 4.07e-02 | 28 |
GO:0070507 | Colorectum | AD | regulation of microtubule cytoskeleton organization | 44/3918 | 148/18723 | 7.05e-03 | 4.31e-02 | 44 |
GO:00160322 | Colorectum | MSS | viral process | 157/3467 | 415/18723 | 7.94e-21 | 6.19e-18 | 157 |
GO:19038292 | Colorectum | MSS | positive regulation of cellular protein localization | 103/3467 | 276/18723 | 1.12e-13 | 2.67e-11 | 103 |
GO:00064032 | Colorectum | MSS | RNA localization | 69/3467 | 201/18723 | 6.33e-08 | 3.26e-06 | 69 |
GO:00516562 | Colorectum | MSS | establishment of organelle localization | 115/3467 | 390/18723 | 7.30e-08 | 3.67e-06 | 115 |
GO:00301002 | Colorectum | MSS | regulation of endocytosis | 63/3467 | 211/18723 | 4.05e-05 | 7.66e-04 | 63 |
GO:00715391 | Colorectum | MSS | protein localization to centrosome | 16/3467 | 33/18723 | 8.66e-05 | 1.40e-03 | 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa032509 | Esophagus | ESCC | Viral life cycle - HIV-1 | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0325014 | Esophagus | ESCC | Viral life cycle - HIV-1 | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BICD1 | SNV | Missense_Mutation | novel | c.1771N>A | p.Glu591Lys | p.E591K | Q96G01 | protein_coding | tolerated(0.24) | benign(0.294) | TCGA-78-7539-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
BICD1 | SNV | Missense_Mutation | c.2736N>T | p.Lys912Asn | p.K912N | Q96G01 | protein_coding | tolerated_low_confidence(0.08) | possibly_damaging(0.624) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BICD1 | SNV | Missense_Mutation | rs777372640 | c.868C>T | p.His290Tyr | p.H290Y | Q96G01 | protein_coding | deleterious(0.02) | benign(0.09) | TCGA-93-7347-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BICD1 | SNV | Missense_Mutation | c.2678T>A | p.Phe893Tyr | p.F893Y | Q96G01 | protein_coding | tolerated_low_confidence(0.35) | benign(0) | TCGA-MP-A4TD-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
BICD1 | SNV | Missense_Mutation | novel | c.359N>T | p.Arg120Leu | p.R120L | Q96G01 | protein_coding | deleterious(0) | benign(0.327) | TCGA-22-4594-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
BICD1 | SNV | Missense_Mutation | novel | c.1325N>T | p.Asn442Ile | p.N442I | Q96G01 | protein_coding | deleterious(0.03) | probably_damaging(0.939) | TCGA-58-8386-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
BICD1 | SNV | Missense_Mutation | novel | c.1078G>T | p.Ala360Ser | p.A360S | Q96G01 | protein_coding | deleterious(0.05) | probably_damaging(0.998) | TCGA-CN-5360-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
BICD1 | SNV | Missense_Mutation | rs762369260 | c.458N>A | p.Arg153Gln | p.R153Q | Q96G01 | protein_coding | tolerated(0.28) | probably_damaging(0.998) | TCGA-CN-5373-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BICD1 | SNV | Missense_Mutation | novel | c.500G>T | p.Arg167Leu | p.R167L | Q96G01 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
BICD1 | SNV | Missense_Mutation | novel | c.241N>T | p.Arg81Trp | p.R81W | Q96G01 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-CN-6013-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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