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Gene: ARHGAP30 |
Gene summary for ARHGAP30 |
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Gene information | Species | Human | Gene symbol | ARHGAP30 | Gene ID | 257106 |
Gene name | Rho GTPase activating protein 30 | |
Gene Alias | ARHGAP30 | |
Cytomap | 1q23.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q7Z6I6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
257106 | ARHGAP30 | C21 | Human | Oral cavity | OSCC | 7.83e-05 | 1.75e-01 | 0.2678 |
257106 | ARHGAP30 | C38 | Human | Oral cavity | OSCC | 7.06e-07 | 6.15e-01 | 0.172 |
257106 | ARHGAP30 | C46 | Human | Oral cavity | OSCC | 1.78e-04 | 1.60e-01 | 0.1673 |
257106 | ARHGAP30 | C57 | Human | Oral cavity | OSCC | 1.43e-12 | 2.87e-01 | 0.1679 |
257106 | ARHGAP30 | C06 | Human | Oral cavity | OSCC | 1.76e-03 | 5.21e-01 | 0.2699 |
257106 | ARHGAP30 | LN46 | Human | Oral cavity | OSCC | 2.08e-04 | 1.20e-01 | 0.1666 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGAP30 | SNV | Missense_Mutation | rs763243355 | c.689N>A | p.Arg230Gln | p.R230Q | Q7Z6I6 | protein_coding | tolerated(0.07) | benign(0.023) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARHGAP30 | SNV | Missense_Mutation | novel | c.3057N>C | p.Gln1019His | p.Q1019H | Q7Z6I6 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.62) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGAP30 | SNV | Missense_Mutation | novel | c.820N>A | p.Glu274Lys | p.E274K | Q7Z6I6 | protein_coding | deleterious(0.02) | probably_damaging(0.93) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGAP30 | SNV | Missense_Mutation | novel | c.3095G>T | p.Arg1032Ile | p.R1032I | Q7Z6I6 | protein_coding | deleterious_low_confidence(0) | benign(0.372) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
ARHGAP30 | SNV | Missense_Mutation | c.1660G>A | p.Glu554Lys | p.E554K | Q7Z6I6 | protein_coding | deleterious(0) | benign(0.283) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
ARHGAP30 | SNV | Missense_Mutation | rs200609833 | c.514G>A | p.Val172Met | p.V172M | Q7Z6I6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
ARHGAP30 | SNV | Missense_Mutation | novel | c.1858N>A | p.Leu620Met | p.L620M | Q7Z6I6 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
ARHGAP30 | SNV | Missense_Mutation | novel | c.2713N>C | p.Ser905Arg | p.S905R | Q7Z6I6 | protein_coding | tolerated_low_confidence(0.06) | benign(0.047) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ARHGAP30 | SNV | Missense_Mutation | novel | c.2148N>T | p.Lys716Asn | p.K716N | Q7Z6I6 | protein_coding | deleterious_low_confidence(0.05) | benign(0.056) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ARHGAP30 | SNV | Missense_Mutation | c.1217N>A | p.Arg406His | p.R406H | Q7Z6I6 | protein_coding | deleterious(0.01) | probably_damaging(0.948) | TCGA-EY-A1GD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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