![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ARHGAP15 |
Gene summary for ARHGAP15 |
![]() |
Gene information | Species | Human | Gene symbol | ARHGAP15 | Gene ID | 55843 |
Gene name | Rho GTPase activating protein 15 | |
Gene Alias | BM046 | |
Cytomap | 2q22.2-q22.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q53QZ3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55843 | ARHGAP15 | EOLP-1 | Human | Oral cavity | EOLP | 2.35e-42 | 9.51e-01 | -0.0202 |
55843 | ARHGAP15 | EOLP-2 | Human | Oral cavity | EOLP | 1.70e-33 | 7.25e-01 | -0.0203 |
55843 | ARHGAP15 | NEOLP-1 | Human | Oral cavity | NEOLP | 1.08e-07 | 4.22e-01 | -0.0194 |
55843 | ARHGAP15 | NEOLP-2 | Human | Oral cavity | NEOLP | 1.31e-07 | 3.47e-01 | -0.0196 |
55843 | ARHGAP15 | NEOLP-3 | Human | Oral cavity | NEOLP | 6.83e-12 | 4.45e-01 | -0.0191 |
55843 | ARHGAP15 | ATC13 | Human | Thyroid | ATC | 7.13e-41 | 8.34e-01 | 0.34 |
55843 | ARHGAP15 | ATC5 | Human | Thyroid | ATC | 6.10e-44 | 8.96e-01 | 0.34 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002260425 | Oral cavity | EOLP | regulation of cell morphogenesis | 69/2218 | 309/18723 | 1.21e-07 | 4.01e-06 | 69 |
GO:000836024 | Oral cavity | EOLP | regulation of cell shape | 37/2218 | 154/18723 | 1.80e-05 | 2.90e-04 | 37 |
GO:004308714 | Oral cavity | EOLP | regulation of GTPase activity | 66/2218 | 348/18723 | 6.92e-05 | 8.55e-04 | 66 |
GO:00510569 | Oral cavity | EOLP | regulation of small GTPase mediated signal transduction | 51/2218 | 302/18723 | 5.67e-03 | 2.92e-02 | 51 |
GO:002260433 | Oral cavity | NEOLP | regulation of cell morphogenesis | 69/2005 | 309/18723 | 2.07e-09 | 1.29e-07 | 69 |
GO:000836033 | Oral cavity | NEOLP | regulation of cell shape | 41/2005 | 154/18723 | 2.35e-08 | 1.03e-06 | 41 |
GO:005105614 | Oral cavity | NEOLP | regulation of small GTPase mediated signal transduction | 49/2005 | 302/18723 | 2.04e-03 | 1.36e-02 | 49 |
GO:004308722 | Oral cavity | NEOLP | regulation of GTPase activity | 54/2005 | 348/18723 | 3.36e-03 | 2.00e-02 | 54 |
GO:002260429 | Thyroid | ATC | regulation of cell morphogenesis | 171/6293 | 309/18723 | 2.36e-15 | 1.70e-13 | 171 |
GO:000836026 | Thyroid | ATC | regulation of cell shape | 91/6293 | 154/18723 | 7.33e-11 | 2.31e-09 | 91 |
GO:005105618 | Thyroid | ATC | regulation of small GTPase mediated signal transduction | 141/6293 | 302/18723 | 1.43e-06 | 1.77e-05 | 141 |
GO:004308719 | Thyroid | ATC | regulation of GTPase activity | 153/6293 | 348/18723 | 3.24e-05 | 2.68e-04 | 153 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGAP15 | SNV | Missense_Mutation | rs781224062 | c.53N>A | p.Arg18His | p.R18H | Q53QZ3 | protein_coding | tolerated(0.15) | benign(0) | TCGA-CR-6471-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | PD |
ARHGAP15 | SNV | Missense_Mutation | rs150643555 | c.362N>G | p.Lys121Arg | p.K121R | Q53QZ3 | protein_coding | tolerated(0.05) | possibly_damaging(0.893) | TCGA-CR-7374-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGAP15 | SNV | Missense_Mutation | novel | c.20N>G | p.Ser7Cys | p.S7C | Q53QZ3 | protein_coding | tolerated(0.18) | benign(0) | TCGA-CV-6935-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ARHGAP15 | SNV | Missense_Mutation | c.673N>A | p.Glu225Lys | p.E225K | Q53QZ3 | protein_coding | tolerated(0.11) | benign(0.014) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ARHGAP15 | SNV | Missense_Mutation | novel | c.838G>A | p.Gly280Ser | p.G280S | Q53QZ3 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-P3-A6SX-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | unknown | CR |
ARHGAP15 | SNV | Missense_Mutation | c.131N>C | p.Met44Thr | p.M44T | Q53QZ3 | protein_coding | deleterious(0) | benign(0.04) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ARHGAP15 | SNV | Missense_Mutation | c.799N>C | p.Thr267Pro | p.T267P | Q53QZ3 | protein_coding | deleterious(0) | benign(0.046) | TCGA-BR-4366-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARHGAP15 | SNV | Missense_Mutation | c.721N>T | p.Ser241Cys | p.S241C | Q53QZ3 | protein_coding | deleterious(0.03) | probably_damaging(0.94) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARHGAP15 | SNV | Missense_Mutation | c.208N>T | p.Asp70Tyr | p.D70Y | Q53QZ3 | protein_coding | tolerated(0.07) | benign(0.396) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
ARHGAP15 | SNV | Missense_Mutation | rs764158566 | c.293T>A | p.Leu98Gln | p.L98Q | Q53QZ3 | protein_coding | tolerated(0.15) | possibly_damaging(0.775) | TCGA-BR-A44U-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |