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Gene: APBB1IP |
Gene summary for APBB1IP |
Gene summary. |
Gene information | Species | Human | Gene symbol | APBB1IP | Gene ID | 54518 |
Gene name | amyloid beta precursor protein binding family B member 1 interacting protein | |
Gene Alias | INAG1 | |
Cytomap | 10p12.1 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q7Z5R6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54518 | APBB1IP | NAFLD1 | Human | Liver | NAFLD | 3.28e-07 | 8.10e-01 | -0.04 |
54518 | APBB1IP | S43 | Human | Liver | Cirrhotic | 1.03e-07 | -1.64e-01 | -0.0187 |
54518 | APBB1IP | HCC1_Meng | Human | Liver | HCC | 2.21e-25 | -1.55e-01 | 0.0246 |
54518 | APBB1IP | HCC2_Meng | Human | Liver | HCC | 1.10e-06 | -2.25e-01 | 0.0107 |
54518 | APBB1IP | cirrhotic2 | Human | Liver | Cirrhotic | 6.60e-03 | -3.89e-02 | 0.0201 |
54518 | APBB1IP | HCC2 | Human | Liver | HCC | 8.56e-03 | 2.24e+00 | 0.5341 |
54518 | APBB1IP | S029 | Human | Liver | HCC | 2.56e-02 | 4.69e-01 | 0.2581 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00457857 | Liver | Cirrhotic | positive regulation of cell adhesion | 141/4634 | 437/18723 | 2.05e-04 | 1.89e-03 | 141 |
GO:004578512 | Liver | HCC | positive regulation of cell adhesion | 215/7958 | 437/18723 | 2.53e-03 | 1.22e-02 | 215 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa046112 | Liver | HCC | Platelet activation | 71/4020 | 124/8465 | 1.77e-02 | 4.15e-02 | 2.31e-02 | 71 |
hsa0461111 | Liver | HCC | Platelet activation | 71/4020 | 124/8465 | 1.77e-02 | 4.15e-02 | 2.31e-02 | 71 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
APBB1IP | SNV | Missense_Mutation | novel | c.1496N>T | p.Asn499Ile | p.N499I | Q7Z5R6 | protein_coding | tolerated(0.07) | benign(0.184) | TCGA-77-A5G6-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
APBB1IP | SNV | Missense_Mutation | novel | c.1306N>G | p.Leu436Val | p.L436V | Q7Z5R6 | protein_coding | tolerated(0.13) | benign(0.13) | TCGA-92-7340-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
APBB1IP | SNV | Missense_Mutation | novel | c.1325A>G | p.Asn442Ser | p.N442S | Q7Z5R6 | protein_coding | tolerated(0.35) | benign(0.018) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
APBB1IP | SNV | Missense_Mutation | novel | c.1341N>A | p.Asn447Lys | p.N447K | Q7Z5R6 | protein_coding | tolerated(0.3) | benign(0.014) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
APBB1IP | SNV | Missense_Mutation | novel | c.900N>C | p.Glu300Asp | p.E300D | Q7Z5R6 | protein_coding | deleterious(0.02) | possibly_damaging(0.709) | TCGA-NC-A5HR-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
APBB1IP | deletion | Frame_Shift_Del | c.50delG | p.Gly17GlufsTer6 | p.G17Efs*6 | Q7Z5R6 | protein_coding | TCGA-55-8302-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
APBB1IP | SNV | Missense_Mutation | novel | c.1444G>C | p.Glu482Gln | p.E482Q | Q7Z5R6 | protein_coding | deleterious(0) | possibly_damaging(0.714) | TCGA-CQ-A4CD-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
APBB1IP | SNV | Missense_Mutation | novel | c.194N>G | p.Asp65Gly | p.D65G | Q7Z5R6 | protein_coding | deleterious(0) | possibly_damaging(0.522) | TCGA-CR-7368-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unspecific | Complete Response | |
APBB1IP | SNV | Missense_Mutation | novel | c.284N>T | p.His95Leu | p.H95L | Q7Z5R6 | protein_coding | tolerated(0.35) | benign(0) | TCGA-CV-6943-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
APBB1IP | SNV | Missense_Mutation | novel | c.743C>G | p.Thr248Arg | p.T248R | Q7Z5R6 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-CV-7242-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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