GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00457857 | Liver | Cirrhotic | positive regulation of cell adhesion | 141/4634 | 437/18723 | 2.05e-04 | 1.89e-03 | 141 |
GO:001657021 | Liver | HCC | histone modification | 283/7958 | 463/18723 | 2.68e-16 | 2.33e-14 | 283 |
GO:190495122 | Liver | HCC | positive regulation of establishment of protein localization | 207/7958 | 319/18723 | 3.95e-16 | 3.29e-14 | 207 |
GO:005122222 | Liver | HCC | positive regulation of protein transport | 194/7958 | 303/18723 | 2.41e-14 | 1.56e-12 | 194 |
GO:00182052 | Liver | HCC | peptidyl-lysine modification | 230/7958 | 376/18723 | 1.51e-13 | 8.32e-12 | 230 |
GO:00064732 | Liver | HCC | protein acetylation | 135/7958 | 201/18723 | 1.20e-12 | 5.92e-11 | 135 |
GO:00435432 | Liver | HCC | protein acylation | 157/7958 | 243/18723 | 2.40e-12 | 1.12e-10 | 157 |
GO:00183942 | Liver | HCC | peptidyl-lysine acetylation | 116/7958 | 169/18723 | 5.11e-12 | 2.23e-10 | 116 |
GO:00064752 | Liver | HCC | internal protein amino acid acetylation | 107/7958 | 160/18723 | 3.77e-10 | 1.23e-08 | 107 |
GO:00183932 | Liver | HCC | internal peptidyl-lysine acetylation | 105/7958 | 158/18723 | 9.48e-10 | 2.90e-08 | 105 |
GO:00165732 | Liver | HCC | histone acetylation | 101/7958 | 152/18723 | 1.99e-09 | 5.63e-08 | 101 |
GO:00439671 | Liver | HCC | histone H4 acetylation | 50/7958 | 67/18723 | 9.14e-08 | 1.82e-06 | 50 |
GO:001003822 | Liver | HCC | response to metal ion | 208/7958 | 373/18723 | 1.35e-07 | 2.56e-06 | 208 |
GO:005105221 | Liver | HCC | regulation of DNA metabolic process | 198/7958 | 359/18723 | 7.62e-07 | 1.17e-05 | 198 |
GO:200102021 | Liver | HCC | regulation of response to DNA damage stimulus | 128/7958 | 219/18723 | 1.31e-06 | 1.90e-05 | 128 |
GO:19019871 | Liver | HCC | regulation of cell cycle phase transition | 211/7958 | 390/18723 | 2.11e-06 | 2.89e-05 | 211 |
GO:003134611 | Liver | HCC | positive regulation of cell projection organization | 193/7958 | 353/18723 | 2.28e-06 | 3.08e-05 | 193 |
GO:0045786 | Liver | HCC | negative regulation of cell cycle | 204/7958 | 385/18723 | 1.84e-05 | 1.99e-04 | 204 |
GO:00448432 | Liver | HCC | cell cycle G1/S phase transition | 134/7958 | 241/18723 | 2.60e-05 | 2.70e-04 | 134 |
GO:005105411 | Liver | HCC | positive regulation of DNA metabolic process | 113/7958 | 201/18723 | 5.76e-05 | 5.33e-04 | 113 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
APBB1 | SNV | Missense_Mutation | novel | c.1423C>A | p.Gln475Lys | p.Q475K | O00213 | protein_coding | tolerated(0.11) | benign(0.123) | TCGA-46-3765-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
APBB1 | SNV | Missense_Mutation | novel | c.832N>G | p.Thr278Ala | p.T278A | O00213 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-60-2723-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
APBB1 | SNV | Missense_Mutation | | c.1223T>C | p.Leu408Pro | p.L408P | O00213 | protein_coding | deleterious(0.05) | probably_damaging(0.996) | TCGA-66-2759-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR |
APBB1 | SNV | Missense_Mutation | novel | c.670N>G | p.Trp224Gly | p.W224G | O00213 | protein_coding | deleterious(0.01) | possibly_damaging(0.829) | TCGA-77-8138-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
APBB1 | SNV | Missense_Mutation | novel | c.1652T>C | p.Val551Ala | p.V551A | O00213 | protein_coding | tolerated(0.17) | possibly_damaging(0.583) | TCGA-BB-4227-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unspecific | docetaxel | PD |
APBB1 | SNV | Missense_Mutation | | c.599N>T | p.Arg200Leu | p.R200L | O00213 | protein_coding | deleterious(0.01) | probably_damaging(0.972) | TCGA-CQ-6223-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
APBB1 | SNV | Missense_Mutation | novel | c.335N>A | p.Gly112Asp | p.G112D | O00213 | protein_coding | tolerated(0.19) | possibly_damaging(0.461) | TCGA-CR-6487-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
APBB1 | SNV | Missense_Mutation | novel | c.698N>G | p.Ser233Cys | p.S233C | O00213 | protein_coding | deleterious(0) | possibly_damaging(0.712) | TCGA-CV-7095-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
APBB1 | SNV | Missense_Mutation | novel | c.464N>T | p.Gly155Val | p.G155V | O00213 | protein_coding | tolerated(0.2) | possibly_damaging(0.854) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
APBB1 | SNV | Missense_Mutation | rs147235391 | c.1666C>T | p.Pro556Ser | p.P556S | O00213 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D6-A4ZB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |