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Gene: AOX1 |
Gene summary for AOX1 |
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Gene information | Species | Human | Gene symbol | AOX1 | Gene ID | 316 |
Gene name | aldehyde oxidase 1 | |
Gene Alias | AO | |
Cytomap | 2q33.1 | |
Gene Type | protein-coding | GO ID | GO:0006805 | UniProtAcc | Q06278 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
316 | AOX1 | NAFLD1 | Human | Liver | NAFLD | 3.68e-13 | 1.35e+00 | -0.04 |
316 | AOX1 | S41 | Human | Liver | Cirrhotic | 1.80e-02 | 5.46e-01 | -0.0343 |
316 | AOX1 | S43 | Human | Liver | Cirrhotic | 5.26e-06 | -7.65e-02 | -0.0187 |
316 | AOX1 | S44 | Human | Liver | HCC | 4.47e-06 | 8.89e-01 | -0.0083 |
316 | AOX1 | HCC1_Meng | Human | Liver | HCC | 3.80e-62 | -1.81e-01 | 0.0246 |
316 | AOX1 | HCC2_Meng | Human | Liver | HCC | 1.05e-09 | -3.48e-01 | 0.0107 |
316 | AOX1 | cirrhotic1 | Human | Liver | Cirrhotic | 1.83e-06 | -3.36e-01 | 0.0202 |
316 | AOX1 | cirrhotic2 | Human | Liver | Cirrhotic | 3.21e-07 | -3.44e-01 | 0.0201 |
316 | AOX1 | HCC1 | Human | Liver | HCC | 2.72e-25 | 5.86e+00 | 0.5336 |
316 | AOX1 | HCC5 | Human | Liver | HCC | 3.82e-03 | 3.98e+00 | 0.4932 |
316 | AOX1 | Pt13.a | Human | Liver | HCC | 8.36e-03 | -2.37e-01 | 0.021 |
316 | AOX1 | Pt13.b | Human | Liver | HCC | 1.05e-07 | -2.10e-01 | 0.0251 |
316 | AOX1 | Pt14.d | Human | Liver | HCC | 1.73e-03 | -2.14e-01 | 0.0143 |
316 | AOX1 | S028 | Human | Liver | HCC | 4.14e-08 | 6.90e-01 | 0.2503 |
316 | AOX1 | S029 | Human | Liver | HCC | 2.84e-12 | 9.54e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00094107 | Liver | NAFLD | response to xenobiotic stimulus | 88/1882 | 462/18723 | 2.53e-09 | 4.11e-07 | 88 |
GO:00714663 | Liver | NAFLD | cellular response to xenobiotic stimulus | 33/1882 | 177/18723 | 3.54e-04 | 5.36e-03 | 33 |
GO:00068054 | Liver | NAFLD | xenobiotic metabolic process | 22/1882 | 111/18723 | 1.42e-03 | 1.58e-02 | 22 |
GO:000941012 | Liver | Cirrhotic | response to xenobiotic stimulus | 165/4634 | 462/18723 | 6.82e-08 | 2.09e-06 | 165 |
GO:00714661 | Liver | Cirrhotic | cellular response to xenobiotic stimulus | 66/4634 | 177/18723 | 1.34e-04 | 1.31e-03 | 66 |
GO:000680511 | Liver | Cirrhotic | xenobiotic metabolic process | 43/4634 | 111/18723 | 7.51e-04 | 5.54e-03 | 43 |
GO:000941022 | Liver | HCC | response to xenobiotic stimulus | 248/7958 | 462/18723 | 6.47e-07 | 1.02e-05 | 248 |
GO:00714662 | Liver | HCC | cellular response to xenobiotic stimulus | 93/7958 | 177/18723 | 4.35e-03 | 1.89e-02 | 93 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa002806 | Liver | NAFLD | Valine, leucine and isoleucine degradation | 20/1043 | 48/8465 | 3.03e-07 | 1.65e-05 | 1.33e-05 | 20 |
hsa0028011 | Liver | NAFLD | Valine, leucine and isoleucine degradation | 20/1043 | 48/8465 | 3.03e-07 | 1.65e-05 | 1.33e-05 | 20 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AOX1 | SNV | Missense_Mutation | c.3545N>C | p.Asn1182Thr | p.N1182T | Q06278 | protein_coding | tolerated(0.82) | benign(0.007) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AOX1 | SNV | Missense_Mutation | c.2381A>G | p.Asn794Ser | p.N794S | Q06278 | protein_coding | tolerated(0.11) | possibly_damaging(0.591) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
AOX1 | SNV | Missense_Mutation | rs765612875 | c.1477N>A | p.Ala493Thr | p.A493T | Q06278 | protein_coding | deleterious(0.02) | possibly_damaging(0.734) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AOX1 | SNV | Missense_Mutation | rs760074982 | c.1909G>A | p.Gly637Ser | p.G637S | Q06278 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AOX1 | SNV | Missense_Mutation | c.968T>C | p.Val323Ala | p.V323A | Q06278 | protein_coding | deleterious(0.02) | benign(0.101) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
AOX1 | SNV | Missense_Mutation | c.1877C>A | p.Ser626Tyr | p.S626Y | Q06278 | protein_coding | deleterious(0) | possibly_damaging(0.838) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
AOX1 | SNV | Missense_Mutation | rs756261449 | c.2458G>A | p.Val820Ile | p.V820I | Q06278 | protein_coding | tolerated(1) | benign(0.001) | TCGA-D1-A1NY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
AOX1 | SNV | Missense_Mutation | novel | c.460N>C | p.Tyr154His | p.Y154H | Q06278 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
AOX1 | SNV | Missense_Mutation | rs41309768 | c.2404C>T | p.Arg802Cys | p.R802C | Q06278 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AOX1 | SNV | Missense_Mutation | rs775304628 | c.2542N>T | p.Arg848Cys | p.R848C | Q06278 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
316 | AOX1 | DRUGGABLE GENOME | Menadione | MENADIONE | ||
316 | AOX1 | DRUGGABLE GENOME | azathioprine | AZATHIOPRINE | 19500084 | |
316 | AOX1 | DRUGGABLE GENOME | febuxostat | FEBUXOSTAT | 27798726 | |
316 | AOX1 | DRUGGABLE GENOME | allopurinol | ALLOPURINOL | 27798726 | |
316 | AOX1 | DRUGGABLE GENOME | XK469 | |||
316 | AOX1 | DRUGGABLE GENOME | Isovanillin | ISOVANILLIN |
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