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Gene: ANKRD26 |
Gene summary for ANKRD26 |
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Gene information | Species | Human | Gene symbol | ANKRD26 | Gene ID | 22852 |
Gene name | ankyrin repeat domain 26 | |
Gene Alias | THC2 | |
Cytomap | 10p12.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9UPS8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22852 | ANKRD26 | LZE4T | Human | Esophagus | ESCC | 8.69e-04 | 1.18e-01 | 0.0811 |
22852 | ANKRD26 | LZE7T | Human | Esophagus | ESCC | 7.32e-03 | 1.77e-01 | 0.0667 |
22852 | ANKRD26 | LZE24T | Human | Esophagus | ESCC | 8.69e-12 | 3.31e-01 | 0.0596 |
22852 | ANKRD26 | P2T-E | Human | Esophagus | ESCC | 1.14e-23 | 5.04e-01 | 0.1177 |
22852 | ANKRD26 | P4T-E | Human | Esophagus | ESCC | 2.36e-16 | 4.16e-01 | 0.1323 |
22852 | ANKRD26 | P5T-E | Human | Esophagus | ESCC | 4.46e-07 | 1.49e-01 | 0.1327 |
22852 | ANKRD26 | P8T-E | Human | Esophagus | ESCC | 8.22e-12 | 1.86e-01 | 0.0889 |
22852 | ANKRD26 | P9T-E | Human | Esophagus | ESCC | 4.10e-03 | 8.11e-02 | 0.1131 |
22852 | ANKRD26 | P10T-E | Human | Esophagus | ESCC | 5.40e-15 | 2.32e-01 | 0.116 |
22852 | ANKRD26 | P11T-E | Human | Esophagus | ESCC | 3.28e-10 | 4.48e-01 | 0.1426 |
22852 | ANKRD26 | P12T-E | Human | Esophagus | ESCC | 4.66e-21 | 4.50e-01 | 0.1122 |
22852 | ANKRD26 | P15T-E | Human | Esophagus | ESCC | 5.42e-13 | 2.87e-01 | 0.1149 |
22852 | ANKRD26 | P16T-E | Human | Esophagus | ESCC | 2.96e-31 | 7.03e-01 | 0.1153 |
22852 | ANKRD26 | P17T-E | Human | Esophagus | ESCC | 2.50e-02 | 2.15e-01 | 0.1278 |
22852 | ANKRD26 | P20T-E | Human | Esophagus | ESCC | 7.24e-09 | 2.13e-01 | 0.1124 |
22852 | ANKRD26 | P21T-E | Human | Esophagus | ESCC | 3.43e-20 | 4.72e-01 | 0.1617 |
22852 | ANKRD26 | P22T-E | Human | Esophagus | ESCC | 1.84e-15 | 1.79e-01 | 0.1236 |
22852 | ANKRD26 | P23T-E | Human | Esophagus | ESCC | 8.82e-12 | 2.22e-01 | 0.108 |
22852 | ANKRD26 | P24T-E | Human | Esophagus | ESCC | 2.49e-08 | 1.97e-01 | 0.1287 |
22852 | ANKRD26 | P26T-E | Human | Esophagus | ESCC | 4.49e-22 | 4.91e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00454449 | Esophagus | ESCC | fat cell differentiation | 135/8552 | 229/18723 | 3.38e-05 | 2.78e-04 | 135 |
GO:00455984 | Esophagus | ESCC | regulation of fat cell differentiation | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
GO:00454441 | Liver | HCC | fat cell differentiation | 120/7958 | 229/18723 | 1.52e-03 | 8.05e-03 | 120 |
GO:004544418 | Thyroid | PTC | fat cell differentiation | 102/5968 | 229/18723 | 3.66e-05 | 3.40e-04 | 102 |
GO:004559814 | Thyroid | PTC | regulation of fat cell differentiation | 59/5968 | 139/18723 | 5.50e-03 | 2.50e-02 | 59 |
GO:004544423 | Thyroid | ATC | fat cell differentiation | 105/6293 | 229/18723 | 7.42e-05 | 5.62e-04 | 105 |
GO:004559822 | Thyroid | ATC | regulation of fat cell differentiation | 61/6293 | 139/18723 | 7.28e-03 | 2.86e-02 | 61 |
GO:0045599 | Thyroid | ATC | negative regulation of fat cell differentiation | 28/6293 | 56/18723 | 8.12e-03 | 3.13e-02 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKRD26 | SNV | Missense_Mutation | c.2769N>A | p.Met923Ile | p.M923I | Q9UPS8 | protein_coding | tolerated(0.14) | benign(0.053) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANKRD26 | SNV | Missense_Mutation | c.239A>G | p.Asn80Ser | p.N80S | Q9UPS8 | protein_coding | tolerated(0.15) | benign(0.02) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANKRD26 | SNV | Missense_Mutation | c.4801N>T | p.Leu1601Phe | p.L1601F | Q9UPS8 | protein_coding | tolerated(0.13) | benign(0.073) | TCGA-AP-A05N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANKRD26 | SNV | Missense_Mutation | c.244N>G | p.Thr82Ala | p.T82A | Q9UPS8 | protein_coding | deleterious(0) | benign(0.34) | TCGA-AP-A05N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANKRD26 | SNV | Missense_Mutation | novel | c.4400N>A | p.Arg1467Lys | p.R1467K | Q9UPS8 | protein_coding | tolerated(1) | benign(0) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ANKRD26 | SNV | Missense_Mutation | c.1591G>A | p.Glu531Lys | p.E531K | Q9UPS8 | protein_coding | tolerated(0.22) | benign(0.007) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANKRD26 | SNV | Missense_Mutation | novel | c.1808A>G | p.Tyr603Cys | p.Y603C | Q9UPS8 | protein_coding | tolerated(0.18) | benign(0) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRD26 | SNV | Missense_Mutation | c.2780N>C | p.Glu927Ala | p.E927A | Q9UPS8 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANKRD26 | SNV | Missense_Mutation | rs766543259 | c.2929N>T | p.Arg977Trp | p.R977W | Q9UPS8 | protein_coding | deleterious(0) | possibly_damaging(0.627) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ANKRD26 | SNV | Missense_Mutation | rs373167535 | c.2732C>T | p.Ser911Leu | p.S911L | Q9UPS8 | protein_coding | tolerated(1) | benign(0) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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