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Gene: ACSL4 |
Gene summary for ACSL4 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ACSL4 | Gene ID | 2182 |
Gene name | acyl-CoA synthetase long chain family member 4 | |
Gene Alias | ACS4 | |
Cytomap | Xq23 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O60488 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2182 | ACSL4 | CA_HPV_1 | Human | Cervix | CC | 2.70e-06 | -2.97e-01 | 0.0264 |
2182 | ACSL4 | CA_HPV_3 | Human | Cervix | CC | 2.12e-07 | -3.90e-01 | 0.0414 |
2182 | ACSL4 | N_HPV_2 | Human | Cervix | N_HPV | 8.62e-10 | -3.51e-01 | -0.0131 |
2182 | ACSL4 | CCII_1 | Human | Cervix | CC | 7.28e-14 | -7.67e-01 | 0.3249 |
2182 | ACSL4 | Tumor | Human | Cervix | CC | 4.27e-29 | -7.43e-01 | 0.1241 |
2182 | ACSL4 | sample1 | Human | Cervix | CC | 3.49e-04 | -5.85e-01 | 0.0959 |
2182 | ACSL4 | sample3 | Human | Cervix | CC | 1.29e-25 | -6.96e-01 | 0.1387 |
2182 | ACSL4 | H2 | Human | Cervix | HSIL_HPV | 3.37e-02 | -2.74e-01 | 0.0632 |
2182 | ACSL4 | L1 | Human | Cervix | CC | 1.50e-22 | -8.24e-01 | 0.0802 |
2182 | ACSL4 | T1 | Human | Cervix | CC | 1.78e-17 | -6.87e-01 | 0.0918 |
2182 | ACSL4 | T3 | Human | Cervix | CC | 7.30e-22 | -6.87e-01 | 0.1389 |
2182 | ACSL4 | LZE4T | Human | Esophagus | ESCC | 7.25e-08 | -1.51e-01 | 0.0811 |
2182 | ACSL4 | LZE8T | Human | Esophagus | ESCC | 6.05e-04 | -3.63e-02 | 0.067 |
2182 | ACSL4 | P2T-E | Human | Esophagus | ESCC | 6.80e-05 | 1.58e-01 | 0.1177 |
2182 | ACSL4 | P4T-E | Human | Esophagus | ESCC | 2.26e-18 | 8.06e-02 | 0.1323 |
2182 | ACSL4 | P5T-E | Human | Esophagus | ESCC | 2.83e-20 | -3.36e-02 | 0.1327 |
2182 | ACSL4 | P8T-E | Human | Esophagus | ESCC | 5.19e-11 | -4.85e-02 | 0.0889 |
2182 | ACSL4 | P9T-E | Human | Esophagus | ESCC | 6.44e-06 | 2.63e-01 | 0.1131 |
2182 | ACSL4 | P10T-E | Human | Esophagus | ESCC | 2.36e-13 | 4.83e-02 | 0.116 |
2182 | ACSL4 | P12T-E | Human | Esophagus | ESCC | 1.27e-18 | -1.16e-01 | 0.1122 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005122210 | Cervix | CC | positive regulation of protein transport | 72/2311 | 303/18723 | 2.36e-08 | 1.70e-06 | 72 |
GO:190495110 | Cervix | CC | positive regulation of establishment of protein localization | 73/2311 | 319/18723 | 9.69e-08 | 5.25e-06 | 73 |
GO:00163587 | Cervix | CC | dendrite development | 58/2311 | 243/18723 | 4.52e-07 | 1.76e-05 | 58 |
GO:003166710 | Cervix | CC | response to nutrient levels | 92/2311 | 474/18723 | 5.80e-06 | 1.42e-04 | 92 |
GO:00609965 | Cervix | CC | dendritic spine development | 28/2311 | 99/18723 | 1.61e-05 | 3.15e-04 | 28 |
GO:00075654 | Cervix | CC | female pregnancy | 43/2311 | 193/18723 | 7.62e-05 | 1.04e-03 | 43 |
GO:00447064 | Cervix | CC | multi-multicellular organism process | 45/2311 | 220/18723 | 4.14e-04 | 4.21e-03 | 45 |
GO:00196939 | Cervix | CC | ribose phosphate metabolic process | 72/2311 | 396/18723 | 4.49e-04 | 4.48e-03 | 72 |
GO:00092599 | Cervix | CC | ribonucleotide metabolic process | 70/2311 | 385/18723 | 5.35e-04 | 5.18e-03 | 70 |
GO:00463908 | Cervix | CC | ribose phosphate biosynthetic process | 39/2311 | 190/18723 | 9.02e-04 | 7.77e-03 | 39 |
GO:000915010 | Cervix | CC | purine ribonucleotide metabolic process | 66/2311 | 368/18723 | 1.09e-03 | 9.07e-03 | 66 |
GO:00092608 | Cervix | CC | ribonucleotide biosynthetic process | 37/2311 | 182/18723 | 1.44e-03 | 1.13e-02 | 37 |
GO:00507148 | Cervix | CC | positive regulation of protein secretion | 29/2311 | 137/18723 | 2.40e-03 | 1.70e-02 | 29 |
GO:00091529 | Cervix | CC | purine ribonucleotide biosynthetic process | 34/2311 | 169/18723 | 2.62e-03 | 1.81e-02 | 34 |
GO:000616310 | Cervix | CC | purine nucleotide metabolic process | 67/2311 | 396/18723 | 4.41e-03 | 2.69e-02 | 67 |
GO:00320245 | Cervix | CC | positive regulation of insulin secretion | 18/2311 | 78/18723 | 5.94e-03 | 3.40e-02 | 18 |
GO:007252110 | Cervix | CC | purine-containing compound metabolic process | 69/2311 | 416/18723 | 6.27e-03 | 3.54e-02 | 69 |
GO:000911710 | Cervix | CC | nucleotide metabolic process | 79/2311 | 489/18723 | 7.16e-03 | 3.85e-02 | 79 |
GO:00075846 | Cervix | CC | response to nutrient | 33/2311 | 174/18723 | 7.65e-03 | 4.07e-02 | 33 |
GO:00158337 | Cervix | CC | peptide transport | 46/2311 | 264/18723 | 9.69e-03 | 4.78e-02 | 46 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0471420 | Cervix | CC | Thermogenesis | 76/1267 | 232/8465 | 4.29e-12 | 1.16e-10 | 6.85e-11 | 76 |
hsa0421614 | Cervix | CC | Ferroptosis | 14/1267 | 41/8465 | 1.75e-03 | 7.21e-03 | 4.26e-03 | 14 |
hsa04714110 | Cervix | CC | Thermogenesis | 76/1267 | 232/8465 | 4.29e-12 | 1.16e-10 | 6.85e-11 | 76 |
hsa0421615 | Cervix | CC | Ferroptosis | 14/1267 | 41/8465 | 1.75e-03 | 7.21e-03 | 4.26e-03 | 14 |
hsa0471425 | Cervix | HSIL_HPV | Thermogenesis | 25/459 | 232/8465 | 7.63e-04 | 5.88e-03 | 4.76e-03 | 25 |
hsa0471435 | Cervix | HSIL_HPV | Thermogenesis | 25/459 | 232/8465 | 7.63e-04 | 5.88e-03 | 4.76e-03 | 25 |
hsa0471444 | Cervix | N_HPV | Thermogenesis | 27/349 | 232/8465 | 9.35e-07 | 1.41e-05 | 1.10e-05 | 27 |
hsa0421624 | Cervix | N_HPV | Ferroptosis | 6/349 | 41/8465 | 6.24e-03 | 3.24e-02 | 2.54e-02 | 6 |
hsa0471454 | Cervix | N_HPV | Thermogenesis | 27/349 | 232/8465 | 9.35e-07 | 1.41e-05 | 1.10e-05 | 27 |
hsa0421634 | Cervix | N_HPV | Ferroptosis | 6/349 | 41/8465 | 6.24e-03 | 3.24e-02 | 2.54e-02 | 6 |
hsa04714211 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa0421629 | Esophagus | ESCC | Ferroptosis | 33/4205 | 41/8465 | 4.58e-05 | 1.99e-04 | 1.02e-04 | 33 |
hsa012129 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa041467 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa04714310 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa0421638 | Esophagus | ESCC | Ferroptosis | 33/4205 | 41/8465 | 4.58e-05 | 1.99e-04 | 1.02e-04 | 33 |
hsa0121214 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa0414612 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa0471422 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
hsa012124 | Liver | HCC | Fatty acid metabolism | 45/4020 | 57/8465 | 1.05e-06 | 1.10e-05 | 6.09e-06 | 45 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACSL4 | insertion | Frame_Shift_Ins | novel | c.345_346insT | p.Lys116Ter | p.K116* | O60488 | protein_coding | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ACSL4 | insertion | Frame_Shift_Ins | novel | c.1819dupA | p.Ser607LysfsTer2 | p.S607Kfs*2 | O60488 | protein_coding | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ACSL4 | insertion | Frame_Shift_Ins | novel | c.1071dupA | p.Gly358ArgfsTer23 | p.G358Rfs*23 | O60488 | protein_coding | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ACSL4 | SNV | Missense_Mutation | rs868773655 | c.1392N>T | p.Gln464His | p.Q464H | O60488 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-49-6767-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ACSL4 | SNV | Missense_Mutation | c.74N>C | p.Leu25Pro | p.L25P | O60488 | protein_coding | deleterious(0) | possibly_damaging(0.73) | TCGA-55-6971-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ACSL4 | SNV | Missense_Mutation | c.1822N>T | p.Asp608Tyr | p.D608Y | O60488 | protein_coding | tolerated(1) | benign(0.029) | TCGA-55-8514-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ACSL4 | SNV | Missense_Mutation | novel | c.1907N>T | p.Trp636Leu | p.W636L | O60488 | protein_coding | tolerated(0.15) | benign(0.291) | TCGA-69-8253-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ACSL4 | SNV | Missense_Mutation | novel | c.1769C>A | p.Ala590Asp | p.A590D | O60488 | protein_coding | deleterious(0) | possibly_damaging(0.848) | TCGA-80-5608-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ACSL4 | SNV | Missense_Mutation | rs770302078 | c.281A>G | p.Asp94Gly | p.D94G | O60488 | protein_coding | tolerated(0.36) | benign(0.206) | TCGA-99-8028-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ACSL4 | SNV | Missense_Mutation | novel | c.1720N>A | p.Leu574Ile | p.L574I | O60488 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BA-4077-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cetuximab | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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