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Gene: ABCA13 |
Gene summary for ABCA13 |
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Gene information | Species | Human | Gene symbol | ABCA13 | Gene ID | 154664 |
Gene name | ATP binding cassette subfamily A member 13 | |
Gene Alias | ABCA13 | |
Cytomap | 7p12.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A0A0MT16 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
154664 | ABCA13 | CCI_1 | Human | Cervix | CC | 1.42e-12 | 9.31e-01 | 0.528 |
154664 | ABCA13 | CCI_2 | Human | Cervix | CC | 1.35e-07 | 5.99e-01 | 0.5249 |
154664 | ABCA13 | CCI_3 | Human | Cervix | CC | 1.28e-19 | 1.23e+00 | 0.516 |
154664 | ABCA13 | CCII_1 | Human | Cervix | CC | 2.38e-08 | 3.78e-01 | 0.3249 |
154664 | ABCA13 | Tumor | Human | Cervix | CC | 7.16e-07 | 2.61e-01 | 0.1241 |
154664 | ABCA13 | sample3 | Human | Cervix | CC | 3.26e-18 | 4.25e-01 | 0.1387 |
154664 | ABCA13 | T3 | Human | Cervix | CC | 5.83e-21 | 4.16e-01 | 0.1389 |
154664 | ABCA13 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-03 | 2.11e-01 | 0.0216 |
154664 | ABCA13 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.67e-02 | 1.39e-01 | -0.0811 |
154664 | ABCA13 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.53e-03 | 1.34e-01 | -0.1088 |
154664 | ABCA13 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.97e-02 | 9.21e-02 | -0.1954 |
154664 | ABCA13 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.47e-06 | 1.64e-01 | -0.059 |
154664 | ABCA13 | HTA11_11156_2000001011 | Human | Colorectum | AD | 5.23e-34 | 2.37e+00 | 0.0397 |
154664 | ABCA13 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.46e-160 | 4.01e+00 | 0.3005 |
154664 | ABCA13 | A002-C-203 | Human | Colorectum | FAP | 1.98e-07 | 4.14e-01 | 0.2786 |
154664 | ABCA13 | A002-C-021 | Human | Colorectum | FAP | 3.10e-04 | 2.25e-01 | 0.1171 |
154664 | ABCA13 | F072B | Human | Colorectum | FAP | 8.39e-03 | 2.45e-01 | 0.257 |
154664 | ABCA13 | LZE4T | Human | Esophagus | ESCC | 9.56e-12 | 3.17e-01 | 0.0811 |
154664 | ABCA13 | LZE5T | Human | Esophagus | ESCC | 4.24e-14 | 1.08e+00 | 0.0514 |
154664 | ABCA13 | LZE7T | Human | Esophagus | ESCC | 2.68e-16 | 6.46e-01 | 0.0667 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00301008 | Cervix | CC | regulation of endocytosis | 47/2311 | 211/18723 | 3.65e-05 | 5.82e-04 | 47 |
GO:00458077 | Cervix | CC | positive regulation of endocytosis | 27/2311 | 100/18723 | 5.55e-05 | 8.10e-04 | 27 |
GO:00484883 | Cervix | CC | synaptic vesicle endocytosis | 16/2311 | 62/18723 | 2.87e-03 | 1.91e-02 | 16 |
GO:01402383 | Cervix | CC | presynaptic endocytosis | 16/2311 | 62/18723 | 2.87e-03 | 1.91e-02 | 16 |
GO:00364655 | Cervix | CC | synaptic vesicle recycling | 17/2311 | 75/18723 | 8.87e-03 | 4.53e-02 | 17 |
GO:0030100 | Colorectum | AD | regulation of endocytosis | 67/3918 | 211/18723 | 1.42e-04 | 2.01e-03 | 67 |
GO:0045807 | Colorectum | AD | positive regulation of endocytosis | 35/3918 | 100/18723 | 7.78e-04 | 7.78e-03 | 35 |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0042886 | Colorectum | AD | amide transport | 83/3918 | 301/18723 | 3.37e-03 | 2.46e-02 | 83 |
GO:0099003 | Colorectum | AD | vesicle-mediated transport in synapse | 57/3918 | 200/18723 | 6.53e-03 | 4.06e-02 | 57 |
GO:00301002 | Colorectum | MSS | regulation of endocytosis | 63/3467 | 211/18723 | 4.05e-05 | 7.66e-04 | 63 |
GO:00458071 | Colorectum | MSS | positive regulation of endocytosis | 33/3467 | 100/18723 | 3.73e-04 | 4.72e-03 | 33 |
GO:00990031 | Colorectum | MSS | vesicle-mediated transport in synapse | 54/3467 | 200/18723 | 1.94e-03 | 1.67e-02 | 54 |
GO:00428861 | Colorectum | MSS | amide transport | 76/3467 | 301/18723 | 2.14e-03 | 1.80e-02 | 76 |
GO:0099504 | Colorectum | MSS | synaptic vesicle cycle | 48/3467 | 181/18723 | 4.85e-03 | 3.39e-02 | 48 |
GO:0048488 | Colorectum | MSS | synaptic vesicle endocytosis | 20/3467 | 62/18723 | 6.63e-03 | 4.38e-02 | 20 |
GO:0140238 | Colorectum | MSS | presynaptic endocytosis | 20/3467 | 62/18723 | 6.63e-03 | 4.38e-02 | 20 |
GO:00108761 | Colorectum | MSS | lipid localization | 104/3467 | 448/18723 | 6.76e-03 | 4.38e-02 | 104 |
GO:0036465 | Colorectum | MSS | synaptic vesicle recycling | 23/3467 | 75/18723 | 7.49e-03 | 4.72e-02 | 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABCA13 | SNV | Missense_Mutation | novel | c.3770T>C | p.Leu1257Pro | p.L1257P | protein_coding | deleterious(0) | probably_damaging(0.942) | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ABCA13 | SNV | Missense_Mutation | novel | c.15034T>G | p.Phe5012Val | p.F5012V | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ABCA13 | SNV | Missense_Mutation | c.400N>G | p.Asn134Asp | p.N134D | protein_coding | tolerated(0.61) | benign(0.408) | TCGA-FP-A4BF-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | ||
ABCA13 | SNV | Missense_Mutation | rs774675807 | c.4778N>C | p.Val1593Ala | p.V1593A | protein_coding | deleterious(0) | benign(0.108) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
ABCA13 | SNV | Missense_Mutation | c.14170N>G | p.Ser4724Gly | p.S4724G | protein_coding | deleterious(0.03) | benign(0.373) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | ||
ABCA13 | SNV | Missense_Mutation | rs372286953 | c.14186G>A | p.Arg4729His | p.R4729H | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-HU-A4G9-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ABCA13 | SNV | Missense_Mutation | c.3762N>T | p.Glu1254Asp | p.E1254D | protein_coding | tolerated(0.09) | probably_damaging(0.998) | TCGA-HU-A4H3-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | ts-1 | PD | ||
ABCA13 | SNV | Missense_Mutation | novel | c.12021N>A | p.Asp4007Glu | p.D4007E | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-IN-8462-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | PD | |
ABCA13 | SNV | Missense_Mutation | novel | c.1301N>C | p.Asn434Thr | p.N434T | protein_coding | tolerated(0.2) | benign(0.228) | TCGA-IN-A6RL-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
ABCA13 | SNV | Missense_Mutation | rs369296047 | c.13975G>A | p.Val4659Met | p.V4659M | protein_coding | tolerated(0.07) | benign(0.067) | TCGA-IN-AB1V-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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