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Gene: ADGRV1 |
Gene summary for ADGRV1 |
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Gene information | Species | Human | Gene symbol | ADGRV1 | Gene ID | 84059 |
Gene name | adhesion G protein-coupled receptor V1 | |
Gene Alias | FEB4 | |
Cytomap | 5q14.3 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | Q8WXG9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84059 | ADGRV1 | LZE4T | Human | Esophagus | ESCC | 8.22e-04 | 1.65e-01 | 0.0811 |
84059 | ADGRV1 | LZE7T | Human | Esophagus | ESCC | 6.18e-06 | 3.83e-01 | 0.0667 |
84059 | ADGRV1 | LZE8T | Human | Esophagus | ESCC | 1.11e-11 | 2.79e-01 | 0.067 |
84059 | ADGRV1 | LZE20T | Human | Esophagus | ESCC | 1.31e-02 | 1.17e-01 | 0.0662 |
84059 | ADGRV1 | LZE24T | Human | Esophagus | ESCC | 6.82e-35 | 1.06e+00 | 0.0596 |
84059 | ADGRV1 | P1T-E | Human | Esophagus | ESCC | 4.15e-02 | 2.66e-01 | 0.0875 |
84059 | ADGRV1 | P2T-E | Human | Esophagus | ESCC | 7.00e-20 | 2.94e-01 | 0.1177 |
84059 | ADGRV1 | P4T-E | Human | Esophagus | ESCC | 9.59e-03 | 8.85e-02 | 0.1323 |
84059 | ADGRV1 | P5T-E | Human | Esophagus | ESCC | 3.55e-03 | 3.59e-02 | 0.1327 |
84059 | ADGRV1 | P8T-E | Human | Esophagus | ESCC | 4.73e-21 | 3.77e-01 | 0.0889 |
84059 | ADGRV1 | P9T-E | Human | Esophagus | ESCC | 3.37e-07 | 1.61e-01 | 0.1131 |
84059 | ADGRV1 | P10T-E | Human | Esophagus | ESCC | 4.72e-08 | 1.79e-01 | 0.116 |
84059 | ADGRV1 | P11T-E | Human | Esophagus | ESCC | 6.72e-11 | 4.91e-01 | 0.1426 |
84059 | ADGRV1 | P12T-E | Human | Esophagus | ESCC | 1.05e-17 | 3.65e-01 | 0.1122 |
84059 | ADGRV1 | P15T-E | Human | Esophagus | ESCC | 1.67e-09 | 2.47e-01 | 0.1149 |
84059 | ADGRV1 | P16T-E | Human | Esophagus | ESCC | 4.83e-11 | 5.56e-02 | 0.1153 |
84059 | ADGRV1 | P20T-E | Human | Esophagus | ESCC | 1.39e-40 | 7.93e-01 | 0.1124 |
84059 | ADGRV1 | P21T-E | Human | Esophagus | ESCC | 7.10e-07 | 6.09e-02 | 0.1617 |
84059 | ADGRV1 | P22T-E | Human | Esophagus | ESCC | 6.93e-16 | 2.55e-01 | 0.1236 |
84059 | ADGRV1 | P23T-E | Human | Esophagus | ESCC | 1.48e-09 | 3.40e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0031647111 | Esophagus | ESCC | regulation of protein stability | 223/8552 | 298/18723 | 5.76e-25 | 1.52e-22 | 223 |
GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
GO:001003827 | Esophagus | ESCC | response to metal ion | 208/8552 | 373/18723 | 5.02e-05 | 3.90e-04 | 208 |
GO:000961216 | Esophagus | ESCC | response to mechanical stimulus | 124/8552 | 216/18723 | 3.30e-04 | 1.94e-03 | 124 |
GO:007124117 | Esophagus | ESCC | cellular response to inorganic substance | 125/8552 | 226/18723 | 2.17e-03 | 9.67e-03 | 125 |
GO:00316478 | Lung | IAC | regulation of protein stability | 62/2061 | 298/18723 | 5.37e-07 | 3.32e-05 | 62 |
GO:00515924 | Lung | IAC | response to calcium ion | 31/2061 | 149/18723 | 3.47e-04 | 5.42e-03 | 31 |
GO:00100388 | Lung | IAC | response to metal ion | 61/2061 | 373/18723 | 1.02e-03 | 1.22e-02 | 61 |
GO:00096125 | Lung | IAC | response to mechanical stimulus | 39/2061 | 216/18723 | 1.29e-03 | 1.45e-02 | 39 |
GO:00018947 | Lung | IAC | tissue homeostasis | 46/2061 | 268/18723 | 1.50e-03 | 1.60e-02 | 46 |
GO:00602497 | Lung | IAC | anatomical structure homeostasis | 51/2061 | 314/18723 | 2.91e-03 | 2.61e-02 | 51 |
GO:003164713 | Lung | AIS | regulation of protein stability | 62/1849 | 298/18723 | 1.06e-08 | 1.63e-06 | 62 |
GO:005159212 | Lung | AIS | response to calcium ion | 30/1849 | 149/18723 | 1.18e-04 | 2.72e-03 | 30 |
GO:001003813 | Lung | AIS | response to metal ion | 57/1849 | 373/18723 | 5.80e-04 | 9.01e-03 | 57 |
GO:000189412 | Lung | AIS | tissue homeostasis | 41/1849 | 268/18723 | 3.13e-03 | 3.01e-02 | 41 |
GO:000189422 | Lung | AAH | tissue homeostasis | 21/613 | 268/18723 | 2.12e-04 | 1.16e-02 | 21 |
GO:006024912 | Lung | AAH | anatomical structure homeostasis | 23/613 | 314/18723 | 2.89e-04 | 1.45e-02 | 23 |
GO:003164723 | Lung | MIAC | regulation of protein stability | 36/967 | 298/18723 | 1.93e-06 | 2.42e-04 | 36 |
GO:001003823 | Lung | MIAC | response to metal ion | 36/967 | 373/18723 | 2.40e-04 | 8.06e-03 | 36 |
GO:005159222 | Lung | MIAC | response to calcium ion | 18/967 | 149/18723 | 6.87e-04 | 1.59e-02 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADGRV1 | SNV | Missense_Mutation | c.13832A>G | p.Lys4611Arg | p.K4611R | Q8WXG9 | protein_coding | tolerated(0.84) | benign(0) | TCGA-DJ-A1QO-01 | Thyroid | thyroid carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
ADGRV1 | SNV | Missense_Mutation | rs760510612 | c.8401G>A | p.Gly2801Arg | p.G2801R | Q8WXG9 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-EL-A3T1-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADGRV1 | SNV | Missense_Mutation | novel | c.3244N>A | p.Pro1082Thr | p.P1082T | Q8WXG9 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-EM-A22J-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADGRV1 | SNV | Missense_Mutation | rs767494507 | c.9901N>T | p.Val3301Phe | p.V3301F | Q8WXG9 | protein_coding | deleterious(0.03) | benign(0.003) | TCGA-EM-A2OZ-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ADGRV1 | SNV | Missense_Mutation | c.12940G>A | p.Asp4314Asn | p.D4314N | Q8WXG9 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-ET-A3DO-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ADGRV1 | deletion | Frame_Shift_Del | c.13504delN | p.Val4502Ter | p.V4502* | Q8WXG9 | protein_coding | TCGA-EL-A3CM-01 | Thyroid | thyroid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |||
ADGRV1 | insertion | In_Frame_Ins | novel | c.9875_9876insTTACTCCTT | p.Tyr3292_Arg3293insTyrSerPhe | p.Y3292_R3293insYSF | Q8WXG9 | protein_coding | TCGA-EL-A3ZQ-01 | Thyroid | thyroid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ADGRV1 | insertion | Frame_Shift_Ins | novel | c.9875_9876insTTACT | p.Arg3293TyrfsTer14 | p.R3293Yfs*14 | Q8WXG9 | protein_coding | TCGA-FY-A40L-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Hormone Therapy | levothyroxine | SD | ||
ADGRV1 | insertion | In_Frame_Ins | novel | c.10749_10750insAGTAAAGAG | p.Ser3583_His3584insSerLysGlu | p.S3583_H3584insSKE | Q8WXG9 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
84059 | ADGRV1 | G PROTEIN COUPLED RECEPTOR, TRANSPORTER, CELL SURFACE, KINASE, DRUGGABLE GENOME | opioids | |||
84059 | ADGRV1 | G PROTEIN COUPLED RECEPTOR, TRANSPORTER, CELL SURFACE, KINASE, DRUGGABLE GENOME | opioids |
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