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Gene: ZNF773 |
Gene summary for ZNF773 |
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Gene information | Species | Human | Gene symbol | ZNF773 | Gene ID | 374928 |
Gene name | zinc finger protein 773 | |
Gene Alias | ZNF419B | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6PK81 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
374928 | ZNF773 | HCC1 | Human | Liver | HCC | 3.54e-11 | 1.87e+00 | 0.5336 |
374928 | ZNF773 | HCC2 | Human | Liver | HCC | 2.50e-09 | 8.46e-01 | 0.5341 |
374928 | ZNF773 | HCC5 | Human | Liver | HCC | 2.46e-18 | 1.18e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF773 | SNV | Missense_Mutation | novel | c.798G>C | p.Gln266His | p.Q266H | Q6PK81 | protein_coding | deleterious(0.04) | possibly_damaging(0.575) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF773 | SNV | Missense_Mutation | rs368874955 | c.811N>A | p.Gly271Arg | p.G271R | Q6PK81 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-63-A5MB-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
ZNF773 | SNV | Missense_Mutation | novel | c.989N>G | p.Pro330Arg | p.P330R | Q6PK81 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-63-A5MB-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
ZNF773 | SNV | Missense_Mutation | novel | c.578N>T | p.Cys193Phe | p.C193F | Q6PK81 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-85-A50Z-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | etoposide | PD |
ZNF773 | SNV | Missense_Mutation | novel | c.820N>T | p.Pro274Ser | p.P274S | Q6PK81 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-98-A539-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ZNF773 | SNV | Missense_Mutation | c.773G>T | p.Arg258Leu | p.R258L | Q6PK81 | protein_coding | tolerated(0.1) | probably_damaging(0.969) | TCGA-NK-A7XE-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF773 | SNV | Missense_Mutation | rs139805602 | c.514N>C | p.Glu172Gln | p.E172Q | Q6PK81 | protein_coding | tolerated(0.56) | benign(0.174) | TCGA-T2-A6X2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ZNF773 | SNV | Missense_Mutation | c.524N>G | p.His175Arg | p.H175R | Q6PK81 | protein_coding | tolerated(0.11) | benign(0.026) | TCGA-EJ-7317-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD | |
ZNF773 | SNV | Missense_Mutation | c.341N>G | p.Gln114Arg | p.Q114R | Q6PK81 | protein_coding | tolerated(0.1) | benign(0.073) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF773 | SNV | Missense_Mutation | c.753C>A | p.Asp251Glu | p.D251E | Q6PK81 | protein_coding | tolerated(1) | benign(0) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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