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Gene: ZNF749 |
Gene summary for ZNF749 |
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Gene information | Species | Human | Gene symbol | ZNF749 | Gene ID | 388567 |
Gene name | zinc finger protein 749 | |
Gene Alias | ZNF749 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O43361 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
388567 | ZNF749 | LZE5T | Human | Esophagus | ESCC | 3.18e-06 | 4.04e-01 | 0.0514 |
388567 | ZNF749 | LZE20T | Human | Esophagus | ESCC | 7.80e-05 | 2.91e-01 | 0.0662 |
388567 | ZNF749 | LZE24T | Human | Esophagus | ESCC | 1.18e-12 | 3.26e-01 | 0.0596 |
388567 | ZNF749 | LZE21T | Human | Esophagus | ESCC | 1.61e-04 | 2.89e-01 | 0.0655 |
388567 | ZNF749 | LZE6T | Human | Esophagus | ESCC | 6.67e-11 | 5.56e-01 | 0.0845 |
388567 | ZNF749 | P1T-E | Human | Esophagus | ESCC | 2.36e-10 | 4.84e-01 | 0.0875 |
388567 | ZNF749 | P2T-E | Human | Esophagus | ESCC | 1.13e-16 | 2.68e-01 | 0.1177 |
388567 | ZNF749 | P4T-E | Human | Esophagus | ESCC | 1.51e-21 | 5.13e-01 | 0.1323 |
388567 | ZNF749 | P8T-E | Human | Esophagus | ESCC | 4.05e-32 | 5.61e-01 | 0.0889 |
388567 | ZNF749 | P9T-E | Human | Esophagus | ESCC | 1.20e-06 | 1.72e-01 | 0.1131 |
388567 | ZNF749 | P10T-E | Human | Esophagus | ESCC | 2.41e-29 | 4.79e-01 | 0.116 |
388567 | ZNF749 | P11T-E | Human | Esophagus | ESCC | 1.93e-12 | 4.43e-01 | 0.1426 |
388567 | ZNF749 | P12T-E | Human | Esophagus | ESCC | 1.62e-13 | 2.25e-01 | 0.1122 |
388567 | ZNF749 | P15T-E | Human | Esophagus | ESCC | 2.73e-19 | 3.85e-01 | 0.1149 |
388567 | ZNF749 | P16T-E | Human | Esophagus | ESCC | 1.68e-13 | 2.45e-01 | 0.1153 |
388567 | ZNF749 | P17T-E | Human | Esophagus | ESCC | 1.40e-13 | 5.99e-01 | 0.1278 |
388567 | ZNF749 | P19T-E | Human | Esophagus | ESCC | 2.85e-04 | 4.52e-01 | 0.1662 |
388567 | ZNF749 | P20T-E | Human | Esophagus | ESCC | 8.73e-12 | 2.69e-01 | 0.1124 |
388567 | ZNF749 | P21T-E | Human | Esophagus | ESCC | 7.98e-13 | 2.50e-01 | 0.1617 |
388567 | ZNF749 | P22T-E | Human | Esophagus | ESCC | 1.07e-50 | 7.38e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF749 | SNV | Missense_Mutation | novel | c.2285N>C | p.Tyr762Ser | p.Y762S | O43361 | protein_coding | tolerated(0.45) | benign(0.101) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF749 | SNV | Missense_Mutation | novel | c.92N>G | p.His31Arg | p.H31R | O43361 | protein_coding | tolerated(0.4) | benign(0.011) | TCGA-34-8454-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ZNF749 | SNV | Missense_Mutation | novel | c.1776N>G | p.Phe592Leu | p.F592L | O43361 | protein_coding | tolerated(0.25) | benign(0.011) | TCGA-39-5034-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZNF749 | SNV | Missense_Mutation | novel | c.1884N>A | p.Ser628Arg | p.S628R | O43361 | protein_coding | tolerated(0.39) | benign(0.018) | TCGA-52-7622-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF749 | SNV | Missense_Mutation | novel | c.1489C>A | p.His497Asn | p.H497N | O43361 | protein_coding | tolerated(0.52) | benign(0.218) | TCGA-58-8393-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF749 | SNV | Missense_Mutation | rs376505582 | c.704N>G | p.Tyr235Cys | p.Y235C | O43361 | protein_coding | tolerated(0.14) | possibly_damaging(0.898) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF749 | SNV | Missense_Mutation | rs368025048 | c.1240N>A | p.Glu414Lys | p.E414K | O43361 | protein_coding | tolerated(0.05) | benign(0.005) | TCGA-IQ-7630-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | CR |
ZNF749 | SNV | Missense_Mutation | c.2205A>C | p.Lys735Asn | p.K735N | O43361 | protein_coding | tolerated(0.43) | possibly_damaging(0.908) | TCGA-G9-6348-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD | |
ZNF749 | SNV | Missense_Mutation | c.1931N>G | p.Glu644Gly | p.E644G | O43361 | protein_coding | deleterious(0) | possibly_damaging(0.562) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |
ZNF749 | SNV | Missense_Mutation | c.1485G>T | p.Gln495His | p.Q495H | O43361 | protein_coding | tolerated(0.19) | benign(0.192) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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