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Gene: ZNF695 |
Gene summary for ZNF695 |
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Gene information | Species | Human | Gene symbol | ZNF695 | Gene ID | 57116 |
Gene name | zinc finger protein 695 | |
Gene Alias | SBZF3 | |
Cytomap | 1q44 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8IW36 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57116 | ZNF695 | P2T-E | Human | Esophagus | ESCC | 7.98e-13 | 2.79e-01 | 0.1177 |
57116 | ZNF695 | P12T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.01e-01 | 0.1122 |
57116 | ZNF695 | P16T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.35e-01 | 0.1153 |
57116 | ZNF695 | P21T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.18e-01 | 0.1617 |
57116 | ZNF695 | P22T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.95e-01 | 0.1236 |
57116 | ZNF695 | P28T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.21e-01 | 0.1149 |
57116 | ZNF695 | P36T-E | Human | Esophagus | ESCC | 1.57e-02 | 1.66e-01 | 0.1187 |
57116 | ZNF695 | P52T-E | Human | Esophagus | ESCC | 3.75e-03 | 9.35e-02 | 0.1555 |
57116 | ZNF695 | P75T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.19e-01 | 0.1125 |
57116 | ZNF695 | P76T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.19e-01 | 0.1207 |
57116 | ZNF695 | P83T-E | Human | Esophagus | ESCC | 1.20e-10 | 3.81e-01 | 0.1738 |
57116 | ZNF695 | P91T-E | Human | Esophagus | ESCC | 4.81e-04 | 5.11e-01 | 0.1828 |
57116 | ZNF695 | P107T-E | Human | Esophagus | ESCC | 4.23e-24 | 5.59e-01 | 0.171 |
57116 | ZNF695 | P128T-E | Human | Esophagus | ESCC | 2.81e-07 | 3.08e-01 | 0.1241 |
57116 | ZNF695 | P130T-E | Human | Esophagus | ESCC | 9.67e-18 | 3.40e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF695 | SNV | Missense_Mutation | rs766317694 | c.634N>C | p.Tyr212His | p.Y212H | Q8IW36 | protein_coding | deleterious(0.04) | benign(0.049) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF695 | SNV | Missense_Mutation | c.1052N>A | p.Thr351Asn | p.T351N | Q8IW36 | protein_coding | deleterious(0) | benign(0.1) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF695 | SNV | Missense_Mutation | rs867754502 | c.871N>G | p.Thr291Ala | p.T291A | Q8IW36 | protein_coding | tolerated(0.08) | benign(0.077) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
ZNF695 | SNV | Missense_Mutation | c.1283G>C | p.Arg428Thr | p.R428T | Q8IW36 | protein_coding | tolerated(0.13) | probably_damaging(0.996) | TCGA-VQ-A8PK-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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