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Gene: ZNF573 |
Gene summary for ZNF573 |
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Gene information | Species | Human | Gene symbol | ZNF573 | Gene ID | 126231 |
Gene name | zinc finger protein 573 | |
Gene Alias | ZNF573 | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q86YE8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
126231 | ZNF573 | PTC01 | Human | Thyroid | PTC | 4.47e-03 | 6.91e-02 | 0.1899 |
126231 | ZNF573 | PTC05 | Human | Thyroid | PTC | 1.63e-04 | 1.57e-01 | 0.2065 |
126231 | ZNF573 | PTC06 | Human | Thyroid | PTC | 4.47e-09 | 1.00e-01 | 0.2057 |
126231 | ZNF573 | PTC07 | Human | Thyroid | PTC | 8.73e-10 | 8.68e-02 | 0.2044 |
126231 | ZNF573 | ATC12 | Human | Thyroid | ATC | 2.74e-05 | 4.69e-02 | 0.34 |
126231 | ZNF573 | ATC13 | Human | Thyroid | ATC | 4.30e-51 | 8.53e-01 | 0.34 |
126231 | ZNF573 | ATC4 | Human | Thyroid | ATC | 6.95e-07 | 5.60e-02 | 0.34 |
126231 | ZNF573 | ATC5 | Human | Thyroid | ATC | 1.76e-54 | 9.02e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF573 | SNV | Missense_Mutation | novel | c.162N>T | p.Arg54Ser | p.R54S | Q86YE8 | protein_coding | deleterious(0.02) | possibly_damaging(0.669) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF573 | SNV | Missense_Mutation | novel | c.161N>C | p.Arg54Thr | p.R54T | Q86YE8 | protein_coding | deleterious(0) | possibly_damaging(0.669) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF573 | SNV | Missense_Mutation | rs758426457 | c.1354N>G | p.Thr452Ala | p.T452A | Q86YE8 | protein_coding | tolerated(0.28) | benign(0.281) | TCGA-21-1083-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF573 | SNV | Missense_Mutation | novel | c.980N>T | p.Lys327Ile | p.K327I | Q86YE8 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-34-8455-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ZNF573 | SNV | Missense_Mutation | c.991G>C | p.Glu331Gln | p.E331Q | Q86YE8 | protein_coding | tolerated(0.05) | probably_damaging(0.94) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF573 | SNV | Missense_Mutation | c.1401G>C | p.Lys467Asn | p.K467N | Q86YE8 | protein_coding | deleterious(0) | possibly_damaging(0.886) | TCGA-66-2758-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF573 | SNV | Missense_Mutation | novel | c.535N>G | p.Leu179Val | p.L179V | Q86YE8 | protein_coding | tolerated(0.85) | benign(0.02) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF573 | SNV | Missense_Mutation | novel | c.1750N>C | p.Cys584Arg | p.C584R | Q86YE8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-XC-AA0X-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF573 | SNV | Missense_Mutation | novel | c.482N>A | p.Pro161His | p.P161H | Q86YE8 | protein_coding | deleterious(0.04) | probably_damaging(0.967) | TCGA-CQ-7071-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF573 | SNV | Missense_Mutation | novel | c.1846N>T | p.Gly616Trp | p.G616W | Q86YE8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CR-7385-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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