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Gene: ZNF530 |
Gene summary for ZNF530 |
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Gene information | Species | Human | Gene symbol | ZNF530 | Gene ID | 348327 |
Gene name | zinc finger protein 530 | |
Gene Alias | ZNF530 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6P9A1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
348327 | ZNF530 | HCC1 | Human | Liver | HCC | 9.63e-03 | 2.31e+00 | 0.5336 |
348327 | ZNF530 | HCC2 | Human | Liver | HCC | 2.47e-19 | 1.52e+00 | 0.5341 |
348327 | ZNF530 | HCC5 | Human | Liver | HCC | 2.05e-12 | 8.21e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF530 | SNV | Missense_Mutation | c.151G>A | p.Ala51Thr | p.A51T | Q6P9A1 | protein_coding | tolerated(1) | benign(0.023) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
ZNF530 | SNV | Missense_Mutation | c.884N>C | p.Tyr295Ser | p.Y295S | Q6P9A1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CG-4475-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF530 | SNV | Missense_Mutation | c.1577N>C | p.Lys526Thr | p.K526T | Q6P9A1 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-F1-6875-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF530 | SNV | Missense_Mutation | rs772007638 | c.913C>T | p.Arg305Cys | p.R305C | Q6P9A1 | protein_coding | tolerated(0.05) | possibly_damaging(0.86) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
ZNF530 | SNV | Missense_Mutation | c.43N>A | p.Ala15Thr | p.A15T | Q6P9A1 | protein_coding | tolerated(1) | benign(0.005) | TCGA-HU-A4H5-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | doxifluridine | SD | |
ZNF530 | SNV | Missense_Mutation | novel | c.1070G>A | p.Gly357Glu | p.G357E | Q6P9A1 | protein_coding | tolerated(0.07) | probably_damaging(0.975) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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