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Gene: ZNF521 |
Gene summary for ZNF521 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF521 | Gene ID | 25925 |
Gene name | zinc finger protein 521 | |
Gene Alias | EHZF | |
Cytomap | 18q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | J3KTI4 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25925 | ZNF521 | ATC12 | Human | Thyroid | ATC | 2.71e-08 | 1.55e-01 | 0.34 |
25925 | ZNF521 | ATC13 | Human | Thyroid | ATC | 1.72e-28 | 5.06e-01 | 0.34 |
25925 | ZNF521 | ATC2 | Human | Thyroid | ATC | 5.35e-04 | 3.20e-01 | 0.34 |
25925 | ZNF521 | ATC4 | Human | Thyroid | ATC | 2.47e-08 | 1.87e-01 | 0.34 |
25925 | ZNF521 | ATC5 | Human | Thyroid | ATC | 1.81e-27 | 5.56e-01 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Thyroid | ATC: Anaplastic thyroid cancer | |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF521 | SNV | Missense_Mutation | novel | c.1846N>A | p.Ser616Thr | p.S616T | Q96K83 | protein_coding | tolerated(0.13) | benign(0.196) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF521 | SNV | Missense_Mutation | novel | c.1682N>A | p.Ser561Tyr | p.S561Y | Q96K83 | protein_coding | deleterious(0.01) | probably_damaging(0.969) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF521 | SNV | Missense_Mutation | c.1539N>A | p.Phe513Leu | p.F513L | Q96K83 | protein_coding | tolerated(0.14) | probably_damaging(0.997) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF521 | SNV | Missense_Mutation | rs140504840 | c.1060N>A | p.Val354Met | p.V354M | Q96K83 | protein_coding | tolerated_low_confidence(1) | benign(0.044) | TCGA-F5-6864-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
ZNF521 | SNV | Missense_Mutation | c.3067N>A | p.Val1023Met | p.V1023M | Q96K83 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G5-6235-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | PD | |
ZNF521 | deletion | Frame_Shift_Del | c.3173delN | p.Gly1058AlafsTer24 | p.G1058Afs*24 | Q96K83 | protein_coding | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
ZNF521 | insertion | Frame_Shift_Ins | novel | c.3912_3913insTA | p.Thr1305Ter | p.T1305* | Q96K83 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF521 | SNV | Missense_Mutation | novel | c.3852N>T | p.Lys1284Asn | p.K1284N | Q96K83 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF521 | SNV | Missense_Mutation | novel | c.3775C>T | p.Pro1259Ser | p.P1259S | Q96K83 | protein_coding | tolerated(0.51) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF521 | SNV | Missense_Mutation | novel | c.2162T>G | p.Phe721Cys | p.F721C | Q96K83 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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