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Gene: ZNF518B |
Gene summary for ZNF518B |
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Gene information | Species | Human | Gene symbol | ZNF518B | Gene ID | 85460 |
Gene name | zinc finger protein 518B | |
Gene Alias | ZNF518B | |
Cytomap | 4p16.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9C0D4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85460 | ZNF518B | LZE2T | Human | Esophagus | ESCC | 4.80e-02 | 3.54e-01 | 0.082 |
85460 | ZNF518B | LZE5T | Human | Esophagus | ESCC | 1.34e-03 | 4.53e-01 | 0.0514 |
85460 | ZNF518B | LZE7T | Human | Esophagus | ESCC | 3.10e-02 | 2.23e-01 | 0.0667 |
85460 | ZNF518B | LZE20T | Human | Esophagus | ESCC | 3.53e-02 | 9.20e-02 | 0.0662 |
85460 | ZNF518B | LZE24T | Human | Esophagus | ESCC | 7.72e-06 | 1.85e-01 | 0.0596 |
85460 | ZNF518B | LZE6T | Human | Esophagus | ESCC | 1.33e-02 | 2.20e-01 | 0.0845 |
85460 | ZNF518B | P2T-E | Human | Esophagus | ESCC | 2.12e-23 | 4.18e-01 | 0.1177 |
85460 | ZNF518B | P4T-E | Human | Esophagus | ESCC | 2.31e-09 | 2.18e-01 | 0.1323 |
85460 | ZNF518B | P5T-E | Human | Esophagus | ESCC | 4.01e-06 | 1.01e-01 | 0.1327 |
85460 | ZNF518B | P8T-E | Human | Esophagus | ESCC | 3.04e-24 | 4.05e-01 | 0.0889 |
85460 | ZNF518B | P9T-E | Human | Esophagus | ESCC | 8.01e-03 | 3.28e-02 | 0.1131 |
85460 | ZNF518B | P10T-E | Human | Esophagus | ESCC | 2.29e-18 | 2.27e-01 | 0.116 |
85460 | ZNF518B | P11T-E | Human | Esophagus | ESCC | 7.07e-11 | 3.41e-01 | 0.1426 |
85460 | ZNF518B | P12T-E | Human | Esophagus | ESCC | 2.70e-11 | 2.66e-01 | 0.1122 |
85460 | ZNF518B | P15T-E | Human | Esophagus | ESCC | 9.75e-10 | 1.91e-01 | 0.1149 |
85460 | ZNF518B | P16T-E | Human | Esophagus | ESCC | 3.40e-18 | 2.63e-01 | 0.1153 |
85460 | ZNF518B | P17T-E | Human | Esophagus | ESCC | 7.53e-05 | 2.08e-01 | 0.1278 |
85460 | ZNF518B | P20T-E | Human | Esophagus | ESCC | 7.02e-04 | 4.02e-02 | 0.1124 |
85460 | ZNF518B | P21T-E | Human | Esophagus | ESCC | 1.17e-05 | 6.50e-02 | 0.1617 |
85460 | ZNF518B | P22T-E | Human | Esophagus | ESCC | 1.24e-05 | 4.96e-02 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:000632514 | Prostate | Tumor | chromatin organization | 104/3246 | 409/18723 | 2.02e-05 | 2.62e-04 | 104 |
GO:000632520 | Thyroid | PTC | chromatin organization | 183/5968 | 409/18723 | 2.55e-08 | 5.70e-07 | 183 |
GO:0006325110 | Thyroid | ATC | chromatin organization | 189/6293 | 409/18723 | 6.40e-08 | 1.13e-06 | 189 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF518B | SNV | Missense_Mutation | rs769738228 | c.2189N>G | p.Asp730Gly | p.D730G | Q9C0D4 | protein_coding | tolerated(0.35) | benign(0) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF518B | SNV | Missense_Mutation | novel | c.857N>C | p.Lys286Thr | p.K286T | Q9C0D4 | protein_coding | tolerated(0.06) | possibly_damaging(0.617) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF518B | SNV | Missense_Mutation | novel | c.2645G>T | p.Arg882Ile | p.R882I | Q9C0D4 | protein_coding | deleterious(0) | possibly_damaging(0.691) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF518B | SNV | Missense_Mutation | novel | c.1682T>C | p.Ile561Thr | p.I561T | Q9C0D4 | protein_coding | tolerated(0.19) | benign(0.001) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
ZNF518B | SNV | Missense_Mutation | c.2576N>T | p.Arg859Ile | p.R859I | Q9C0D4 | protein_coding | deleterious(0) | benign(0.062) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZNF518B | SNV | Missense_Mutation | novel | c.2290N>A | p.Ala764Thr | p.A764T | Q9C0D4 | protein_coding | tolerated(0.54) | benign(0.012) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF518B | SNV | Missense_Mutation | novel | c.602N>T | p.Arg201Ile | p.R201I | Q9C0D4 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF518B | SNV | Missense_Mutation | rs375016865 | c.2531G>A | p.Arg844Gln | p.R844Q | Q9C0D4 | protein_coding | tolerated(0.12) | possibly_damaging(0.537) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF518B | SNV | Missense_Mutation | novel | c.1889G>T | p.Gly630Val | p.G630V | Q9C0D4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF518B | SNV | Missense_Mutation | novel | c.809N>C | p.Asp270Ala | p.D270A | Q9C0D4 | protein_coding | deleterious(0.01) | possibly_damaging(0.622) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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